Comparative Approach MCQ

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• Which of the following is true about the RNAalifold?
  ক

  Dynamic programming is not involved

  খ

  Minimum free energy method is not used

  গ

  Only minimum free energy is used

  ঘ

  Covariation information is taken into consideration
• The predefined alignment requiring method also depends on the quality of the input alignment. If there ___ errors in the alignment, covariation signals ____ detected.
  ক

  are, will be

  খ

  are, will not be

  গ

  are not, will not be

  ঘ

  are not, possibly will not be
• The type of algorithm that _____ predefined alignment is ______ for reasonably conserved sequences.
  ক

  doesn’t require, more successful

  খ

  requires, less successful

  গ

  doesn’t require, relatively successful

  ঘ

  requires, relatively successful
• The type of algorithm that requires predefined alignment, requires the user to provide _______ alignment as input.
  ক

  not necessarily an alignment

  খ

  multiple only

  গ

  pairwise or multiple

  ঘ

  pair wise only
• The comparative-based algorithms can be further divided into two categories based on the type of input data.
  ক

  True

  খ

  False
• An aspect of the comparative method is to select a __________ structure through consensus drawing.
  ক

  relatively distinct

  খ

  remote

  গ

  common

  ঘ

  least abundant
• ___________ of covariation can be ___________ to the RNA structure and functions.
  ক

  Any lack, deleterious

  খ

  Any lack, benign

  গ

  Any abundance, deleterious

  ঘ

  Any inadequacy, advantageous
• To distinguish the conserved secondary structure among multiple related RNA sequences, a concept of “covariation” is used.
  ক

  True

  খ

  False
• The comparative approach uses basic RNA structure based predictions to infer a consensus structure.
  ক

  True

  খ

  False
• In ab initio methods for RNA structure prediction, the prediction results from RNAfold are not always guaranteed to be better than those predicted by Mfold.
  ক

  True

  খ

  False