Chromosomal Abnormalities : Deletion MCQ

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• Which of the following is not true about the Notch gene in Drosophila?
  ক

  It causes a special indentation of the wing margin

  খ

  It is expressed in heterozygous form

  গ

  Notch is lethal in homozygous form

  ঘ

  Notch is recessive to Facet
• Yellow colour of mouse is generated by _________ mutation.
  ক

  Duplication

  খ

  Deletion

  গ

  Inversion

  ঘ

  Translocation
• Deletion of a region led to over expression of a gene X. What do you conclude from this observation?
  ক

  Part of gene X is mutated

  খ

  Promoter of gene X is deleted

  গ

  Regulator of gene X is deleted

  ঘ

  No effect on gene X or its regulators
• You generate a fluorescent probe against a gene that has been deleted. You expose the DNA to the probe and observe it under fluorescent microscope. What will you see?
  ক

  Fluorescence will correspond to the gene of interest

  খ

  There will be a number of regions that emit fluorescence

  গ

  Most parts of the chromosome emits fluorescence

  ঘ

  Nothing is seen under fluorescence microscope
• The appearance of a recessive phenotype due to deletion of dominant gene is called_______________
  ক

  Hemi-dominance

  খ

  Pseudo dominance

  গ

  Imperfect dominance

  ঘ

  Co-dominance
• Which of the following is not a possible cause of lethality of individuals carrying a deletion mutation?
  ক

  Genes that are not haplo sufficient doesn’t produce adequate gene product

  খ

  Genomic imbalance

  গ

  Unmasking of lethal recessive alleles

  ঘ

  Lack of diversity
• You hybridize two cells one of which carries a deletion mutation on chromosome 1. What will you expect to observe?
  ক

  Buckling of chromatin of 1st cell

  খ

  Buckling of chromatin of 2nd cell

  গ

  Twisting and loop formation between the two chromatins

  ঘ

  No observable difference
• What will be the effect of the deletion mutation of a gene at the telomere?
  ক

  Organism will dye

  খ

  Organism will develop serious hazards due to absence of the gene and its product

  গ

  Mild effect on the phenotype

  ঘ

  No effect
• How will you recognize a terminal deletion from breakage and loss at the terminal end?
  ক

  Indistinguishable

  খ

  Terminal break will lead to shorter chromosome than that due to chunk deletion

  গ

  Terminal break will be sticky

  ঘ

  Deletion will be recognized by trans factors
• Deletion in sex chromosome is better tolerated than that in autosome.
  ক

  True

  খ

  False