Choosing the Right Mutations, Database of Mutant Lines and Gene Disruption MCQ

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• If the target organism contains more than one copy of the gene, what is the effect on these copies?
  ক

  Only copy is disrupted

  খ

  All the copies are disrupted

  গ

  It is difficult to ensure that all the copies are disrupted

  ঘ

  Only a specified number of copies are disrupted
• If ______ gene is there, the double crossover may leave ________ in the chromosome.
  ক

  linear, functional copy

  খ

  circular, functional copy

  গ

  linear, a non-functional copy

  ঘ

  circular, a non-functional copy
• Stable acquisition of the marker can take place only if a double crossover over the flanking sequence and their chromosomal counterparts causes the marker’s integration into the chromosome.
  ক

  True

  খ

  False
• The disrupted gene is excised from the vector and is inserted into the target organism. The excised gene should be in which form?
  ক

  Circular

  খ

  Supercoiled

  গ

  Either supercoiled or circular

  ঘ

  Linear
• The gene to be disrupted is cloned and a selectable marker is inserted. What should be the effect of selectable marker?
  ক

  It should have no effect on target gene

  খ

  It should make the target gene non-functional

  গ

  There is no restriction; it can be either functional or non-functional

  ঘ

  It should improvise the chances of survival of the target gene
• The principle of gene disruption is ________ to replace the endogenous chromosomal copy of a gene with __________
  ক

  homologous recombination, inactivated gene

  খ

  reciprocal translocation, inactivated gene

  গ

  homologous recombination, activated gene

  ঘ

  reciprocal translocation, activated gene
• How can mutant strains be produced?
  ক

  In systematic mutagenesis programmes

  খ

  In individual organisms

  গ

  Both by individual organisms and systematic mutagenesis programmes

  ঘ

  Apart from these two, other methods are also used
• The inactivation of endogenous genes may also be helpful in directing the expression of the mutated gene in the absence of background expression of wild type gene.
  ক

  True

  খ

  False
• It is often useful to inactivate endogenous genes in an organism. It might be helpful in finding out _________ role of the wild type gene.
  ক

  biological

  খ

  chemical

  গ

  physiological

  ঘ

  anatomical
• The minor change in amino acid sequence can lead to _______ effect on three dimensional structure and there _____ in the primary sequence.
  ক

  huge, may be no change

  খ

  no, may be huge change

  গ

  very less, is very less change

  ঘ

  huge, would be huge change