Zonesta
Zonesta Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zonesta is a brand name. Its generic name is Zaleplon.
Introduction
Zonesta is an effective hypnotic used for the short-term treatment of insomnia. It is a non-benzodiazepine hypnotic that has a fast onset of action and a relatively short elimination half-life of about 1–2 hours. Zonesta is available in both capsule and tablet form.Uses
Zonesta is primarily used as a short-term treatment to help with the symptoms of insomnia such as difficulty falling asleep or difficulty staying asleep. It can also be used to help reduce the amount of night-time awakenings.Mechanism of Action
Zonesta works by activating GABA receptors in the brain, which result in increased inhibition of neural activity. This decreased activity of neurons in the brain helps to promote feelings of sedation and sleepiness. Zonesta also increases the release of the neurotransmitter dopamine, which also helps to produce a calming and sleep-promoting effect.How Long Does it Take to Work?
Zonesta begins to work quickly, usually within 15 to 30 minutes of taking the medication. The effects of the drug can last for up to 6 hours.Absorption
Zonesta is rapidly and almost completely absorbed in the gastrointestinal tract. It has an oral bioavailability of approximately 68 percent.Route of Elimination
Zonesta is eliminated mainly through the kidneys as unchanged drug or active metabolites. Most of the drug is eliminated within 48 hours of administration.Dosage
Zonesta is available in 5 mg, 10 mg, and 20 mg tablets and capsules. The recommended dose for adults is 10 mg taken orally each night, no more than once per day. For elderly and those with renal or hepatic impairment the recommended dose is 5 mg. The maximum dose should not exceed 20 mg per day.Administration
Zonesta should be taken orally with a full glass of water before going to bed. It can be taken with or without food.Side Effects
Common side effects of Zonesta can include drowsiness, dizziness, headache, dry mouth, nausea, and diarrhea. It is important to contact your doctor if these side effects become bothersome or if they persist.Toxicity
Zonesta has a low toxicity; in overdoses, vomiting and diarrhea are among the more common side effects.Precaution
It is important to use Zonesta with caution in people with a history of mental illness, alcohol or drug abuse, or any other condition that might increase the risk of misuse of the drug. Also, it should not be taken by people who are taking other medications that can cause drowsiness, such as benzodiazepines, opioids, or certain antidepressants.Interactions
Zonesta has the potential to interact with some medications, including other sedatives, certain antidepressants, and certain pain medications. It is important to tell your doctor about all of the medications you are taking before taking Zonesta.Disease Interaction
Zonesta may not be suitable for people with certain medical conditions, such as liver or kidney dysfunction, or conditions that may affect how the body metabolizes drugs, such as a genetic enzyme deficiency. Be sure to discuss any existing medical conditions with your doctor before taking Zonesta.Drug Interaction
Zonesta may interact with a number of other medications, including benzodiazepines, opioids, selective serotonin reuptake inhibitors (SSRIs), and tricyclic antidepressants. Be sure to tell your doctor about any medication you are taking before taking Zonesta.Food Interactions
Zonesta can be taken with or without food. It is best to take the medication on an empty stomach, as this helps to minimize any potential food interactions.Pregnancy Use
Zonesta is a pregnancy Category C medication, meaning it should only be used during pregnancy if the potential benefit justifies the potential risks to the fetus. It is important to speak to your doctor if you are pregnant or planning to become pregnant before taking Zonesta.Lactation Use
Zonesta passes into breast milk and can cause sedation in nursing infants. It is important to speak to your doctor if you are breastfeeding before taking Zonesta.Acute Overdose
In cases of acute overdose with Zonesta, supportive care and monitoring of vital signs are recommended. It is important to contact your doctor or healthcare provider if you or someone you know has taken an overdose of Zonesta.Contraindication
Zonesta is contraindicated for use in people who are hypersensitive or allergic to it or any of its components. It is also not recommended for use in people who are pregnant or breastfeeding.Use Direction
Zonesta should be taken exactly as prescribed by your healthcare provider. It is important to follow the directions and not exceed the prescribed dosage.Storage Condition
Zonesta should be stored at room temperature away from moisture, heat, and light. It should be kept out of the reach of children and pets.Volume of Distribution
The volume of distribution of Zonesta is approximately 0.3 L/kg.Half Life
The elimination half-life of Zonesta is about 1-2 hours.Clearance
The clearance of Zonesta in healthy adults is about 0.16 L/h/kg.Here you find in details version of Zonesta
Some Frequently Asked Questions About Zonesta
What Is Zonesta?
Zonesta is a type of prescription sleeping medication that is used to treat insomnia. It is classified as a non-benzodiazepine sedative-hypnotic drug. Zonesta is not intended for long-term use and should only be used as a short-term sleep aid.
How Does Zonesta Work?
Zonesta works by binding to receptors in the brain, which helps produce a calming and sleep-inducing effect. This helps people fall asleep and stay asleep for a longer period of time.
Who Should Not Take Zonesta?
Patients with certain pre-existing medical conditions and people who take certain medications should not take Zonesta. Before taking the medication, you should speak with your doctor about any health issues you may have that could affect the use of Zonesta.
What Are the Side Effects of Zonesta?
Common side effects of Zonesta include drowsiness, dizziness, headache, nausea, dry mouth and fatigue. In rare cases, more serious side effects can occur such as difficulty breathing, changes in vision, and chest pain. If you experience any of the serious side effects, contact your doctor immediately.
What Are the Risks of Taking Zonesta?
The main risk of taking Zonesta is the risk of dependence. Zonesta has the potential to be habit-forming if used for an extended period of time or in high doses. It can also cause significant impairment to your concentration, coordination and motor skills.
What Is the Recommended Dosage for Zonesta?
The recommended dosage for Zonesta is 5 to 10 mg for adults. Your doctor may adjust your dosage depending on your response to the medication. Do not take more than 20 mg in one dose or more than 40 mg in a 24-hour period.
How Long Does Zonesta Stay in Your System?
The effects of Zonesta can last up to 8 hours. The drug typically leaves your system after 12 hours, but it can be detected in a drug test up to 48 hours after taking it.
Can I Take Zonesta While Pregnant?
No. Zonesta has been classified by the U.S. Food and Drug Administration (FDA) as a pregnancy category C medication, which means it has been proven to be harmful to fetuses in animal studies. As a result, it should not be taken if you are pregnant.
Can I Take Zonesta With Other Medications?
It is important to tell your doctor about any other medications you are taking, including over-the-counter medications and vitamins, before taking Zonesta. Certain drugs can interact with Zonesta, so it is important to tell your doctor about all of the medications you are taking.
Can I Take Zonesta With Alcohol?
No. Zonesta and alcohol can be dangerous when taken together. Alcohol can increase the effect of Zonesta, leading to an increased risk of side effects. It is important to avoid using alcohol while taking Zonesta.
Can I Drive After Taking Zonesta?
No. Zonesta can impair your concentration, coordination and motor skills. It is important to avoid engaging in activities such as driving or operating machinery until the effects of the medication have worn off.
Does Zonesta Have Any Interactions with Food?
No. Zonesta does not interact with food, however it is important to take the medication with or without food. Taking the medication with food can help to reduce nausea.
Can I Split Zonesta Tablets?
Yes, it is safe to split Zonesta tablets to get the desired dose. However, it is important to be aware that cutting the tablets into smaller pieces can affect the rate at which the drug is absorbed into the bloodstream.
What Is the Difference between Zonesta and Zolpidem?
Zonesta and Zolpidem are both prescription sleeping medications, but they have different modes of action. Zonesta works by binding to receptors in the brain, while Zolpidem activates GABA receptors. In general, Zonesta is faster-acting than Zolpidem.
Can I Take Zonesta With Anti-Anxiety Medications?
No. Zonesta should not be taken with any other sedative medications, including anti-anxiety medications. Taking Zonesta with anti-anxiety medications can increase the risk of side effects and serious dangers.
Can I Take Zonesta If I'm Overweight?
Yes. Zonesta is safe for use in patients who are overweight. However, it is important to note that the effects of the medication may be stronger in people who are overweight.
What Should I Do If I Have Trouble Sleeping after Taking Zonesta?
If you have difficulty sleeping after taking Zonesta, talk to your doctor about your symptoms. Your doctor may suggest that you take a different medication or that you try other sleep strategies such as relaxation techniques.
What Should I Do If I Forget to Take a Dose of Zonesta?
If you forget to take a dose of Zonesta, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and take your next dose at the usual time.
Can I Take Zonesta If I'm Breastfeeding?
No. Zonesta has not been tested in breastfeeding women and may pass into breastmilk. As a result, it is important to discuss your options for sleep aid medications with your doctor if you are breastfeeding.
What Is the Cost of Zonesta?
The cost of Zonesta will vary depending on your dosage and whether you are using brand or generic. You should contact your insurance provider for more information about the cost of the medication.
Is Zonesta Available Over-the-Counter?
No. Zonesta is a prescription medication and is not available over-the-counter.
Can Zonesta Be Used to Treat Other Conditions?
No. Zonesta is only approved for the treatment of insomnia and should not be used to treat other conditions.
What Is the Half-Life of Zonesta?
The half-life of Zonesta is about 1 hour. This means that the drug is eliminated from the body within 5 hours.
Who Should Take Zonesta?
Zonesta is generally prescribed to adults who suffer from insomnia. Only take the medication if it has been prescribed by your doctor.
Are There Any Natural Alternatives to Zonesta?
Yes. There are several natural alternatives to Zonesta such as melatonin, valerian root, chamomile and magnesium. However, it is important to speak with your doctor before taking any natural supplements.
What Is the Maximum Dosage of Zonesta?
The maximum recommended dosage for adults is 20 mg in one dose or 40 mg in a 24-hour period.
Is Zonesta Addictive?
Yes. Zonesta has the potential to be habit-forming if taken in high doses or for an extended period of time. If you believe that you may be addicted to Zonesta, contact your doctor for help.
Is Zonesta Safe for Elderly Patients?
Yes. Zonesta is generally safe for use in elderly patients who have trouble sleeping, however it is important to discuss your options with your doctor. Elderly patients may have a higher risk of side effects from the medication.
Can Zonesta Be Taken With Other Sleep Medications?
No. Zonesta should not be taken with any other medications used to treat insomnia, including Zolpidem. Taking two or more sleep medications at the same time can increase the risk of serious side effects.
Can I Take Zonesta If I Have Heart Disease?
No. Zonesta may increase the risk of cardiovascular side effects, such as chest pain and rapid heartbeat, so it should not be taken if you have heart disease.
What Should I Do If I Overdose on Zonesta?
If you or someone you know has taken an overdose of Zonesta, contact your local poison control center or go to the nearest emergency room immediately. Overdosing on Zonesta can be potentially life-threatening.
Can I Take Zonesta If I Have Asthma?
Yes. Zonesta is generally safe for use in patients with asthma, however it is important to discuss your options with your doctor.
Does Zonesta Affect My Mental Alertness?
Yes. Zonesta can cause significant impairment to your concentration, coordination and motor skills, so it is important to avoid activities such as driving or operating machinery until the effects of the medication have worn off.
Does Zonesta Cause Daytime Drowsiness?
Yes. Zonesta can cause significant daytime drowsiness which can last up to 8 hours after taking the medication. It is important to avoid driving or engaging in any potentially hazardous activities until the effects have worn off.
Can Zonesta Be Used to Treat Insomnia Caused by Jet Lag?
No. Zonesta is only approved for the treatment of insomnia and should not be used to treat jet lag. You should speak with your doctor about your options for treating jet lag.
Is Zonesta Safe for Long-Term Use?
No. Zonesta is not approved for long-term use and may become habit-forming if used for an extended period of time. Your doctor will advise you on the safest and most effective way to take Zonesta.
Will Zonesta Affect My Blood Pressure?
Yes. Zonesta may cause low blood pressure which can lead to dizziness or lightheadedness. You should contact your doctor if you experience any symptoms of low blood pressure such as dizziness or lightheadedness after taking Zonesta.