Vitilen

Vitilen Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Vitilen is a brand name. Its generic name is Methoxsalen.

Vitilen

Vitilen is an oral and topical medication sometimes used to treat certain skin disorders, including vitiligo and dermatomycosis. It is a photosensitizing agent, meaning it produces an abnormal sensitivity to ultraviolet radiation. It works through a process called photochemotherapy, where a combination of a light-sensitizing drug and exposure to ultraviolet A (UVA) or ultraviolet B (UVB) light is used to kill off specific skin cells.

Uses For

Vitilen is used, often in combination with ultraviolet (UV) light, to treat vitiligo (a skin disorder in which patches of skin lose their normal color), and certain fungal and fungal-like infections of the skin. It is also used to treat psoriasis (an inflammatory, chronic skin disorder that affects the face, scalp, elbows, and knees).

Mechanism of Action

When exposed to UVA light, Vitilen forms a complex with the UVA light, which then causes a reaction in the skin resulting in the death of some of the skin cells. This helps to reduce skin irritation and inflammation, as well as pigment loss, associated with certain skin disorders. Vitilen works by blocking the absorption of UVA light, which allows more of the light to be absorbed by skin cells. This process helps reduce skin inflammation, inflammation-related pigment loss, and the growth and spread of skin-damaging bacteria.

How Long Does it Take to Work?

The effects of Vitilen are not immediate, and the duration of treatment varies depending on the skin disorder being treated. Generally, it may take several weeks or months of treatment, depending on the type and severity of the disorder.

Absorption

Vitilen is absorbed by the body through the gastrointestinal tract and skin. Peak plasma levels are reached approximately two hours after ingestion.

Route of Elimination

Vitilen is excreted from the body mainly through the urine and feces. It is also excreted in very small amounts through the skin and saliva.

Dosage

Vitilen is usually taken orally as a tablet or capsule, or applied topically as a cream or gel. The dosage of methoxsalen is dependent on the condition being treated, the age of the patient, and the response to treatment. For oral administration, the usual starting dose is 0.1 to 0.2 mg per day. For topical application, the usual starting dose is 1 to 2 mg per day. More information on dosage, administration, and safety information can be found on the product label.

Administration

Vitilen can be taken orally, applied topically, or used in combination with ultraviolet (UV) light therapy. For oral administration, the tablets or capsules should be taken with food to minimize gastrointestinal side effects. For topical application, the cream or gel should be applied twice daily, at least one hour before exposure to UVA light.

Side Effects

Common side effects of Vitilen include headache, nausea, vomiting, itching, burning sensation on the skin, and exacerbation of existing skin conditions. Other serious side effects include photosensitivity reactions, eye irritation, swelling, and potential permanent damage to the skin from prolonged exposure to UVA light.

Toxicity

The safety of Vitilen is not well established for children, pregnant women, and nursing mothers. In addition, exposure to UVA light during treatment can cause long-term skin damage. Overdose of Vitilen can cause serious side effects including stomach pain, nausea, vomiting, and diarrhea. If an overdose is suspected, seek immediate medical attention.

Precautions

Before taking Vitilen, tell your doctor if you have food allergies, heart or liver problems, a history of skin cancer, any skin diseases, or if you are pregnant or nursing. It is important to have regular eye exams while taking Vitilen, as UVA light exposure can cause permanent damage to the eyes. Do not use UVA light equipment for self-treatment.

Interactions

Vitilen may interact with other medications, such as certain antibiotics, antifungals, and anti-inflammatory drugs. Before taking Vitilen, make sure to tell your doctor about all medications you are taking, including over-the-counter medications and any herbal or dietary supplements. It is especially important to tell your doctor if you are taking any medication that could interact with Vitilen.

Disease Interactions

Vitilen should not be used by those with kidney, liver, or heart diseases, or those with a history of skin cancer. It should also not be used by those who are pregnant or nursing, as it can be absorbed by the skin, enter the bloodstream, and could cause harm to an unborn or nursing infant.

Drug Interactions

Vitilen may interact with certain medications, including antibiotics, antifungals, antihistamines, and anti-inflammatory drugs. It is important to tell your doctor about all medications you are taking, as some may interact with Vitilen and cause an increased risk of side effects. Additionally, Vitilen should not be taken within 2 hours of taking certain medications, including tetracyclines, penicillin, nalidixic acid, cimetidine, bismuth subsalicylate, and isoniazid.

Food Interactions

Vitilen should be taken with food to decrease gastrointestinal side effects. It should not be taken with high-fat foods, such as milk, cheese, eggs, and avocados, as these may decrease the absorption of Vitilen.

Pregnancy Use

Vitilen is not recommended for use during pregnancy due to a potential for adverse effects. There is also the risk of harm to the fetus if this product is absorbed through the skin during treatment. Women who are pregnant or planning to become pregnant should talk to their doctor before taking any medication, including Vitilen.

Lactation Use

Vitilen is not recommended for use when breastfeeding due to a potential for adverse effects. It is not known if this product is passed into breastmilk, so it is important to talk to your doctor if you are breastfeeding and considering taking Vitilen.

Acute Overdose

In the event of an overdose, seek immediate medical attention. Signs of acute overdose include nausea, vomiting, stomach pain, and diarrhea. Other symptoms may include weakness, dizziness, confusion, shallow breathing, and seizures.

Contraindication

Vitilen is contraindicated in patients with a history of hypersensitivity to the drug, as well as patients with liver or kidney diseases, a history of skin cancer, or any skin diseases. It should also not be used by those who are pregnant or nursing.

Use Direction

Vitilen should be taken orally or applied topically, and exposure to UVA or UVB light should be avoided during and for several hours after treatment. Refer to the product label for detailed instructions. On the day of treatment, avoid direct sunlight and wear protective clothing if venturing outdoors.

Storage Conditions

Vitilen should be stored at room temperature, away from direct heat, moisture, and light. It should not be stored in the bathroom. Keep this medication away from children and pets.

Volume of Distribution

The volume of distribution of Vitilen is estimated to be 25L/Kg.

Half Life

The half-life of Vitilen is about 2-3 hours.

Clearance

Vitilen is metabolized by the liver, and its clearance is estimated to be 10-20 ml/min/kg.

Here you find in details version of Vitilen

Some Frequently Asked Questions About Vitilen

What Is Vitilen?

Vitilen is a prescription medication, often sold under the brand name Oxsoralen, used to treat several skin diseases. It is most commonly used to treat psoriasis, vitiligo, and certain types of eczema. It is used, either alone or in combination with UV light therapy, to prevent the formation and lessen the severity of abnormal skin cells.

How Does Vitilen Work?

Vitilen works by increasing the skin’s sensitivity to UV light. When exposed to UVA rays, the medication binds to the abnormal skin cells and makes them more vulnerable to light therapy treatments. This combination of light therapy and medication is known as PUVA (psoralen plus ultraviolet A). It’s used to treat several skin conditions, including psoriasis and vitiligo.

What Are the Side Effects of Vitilen?

The most common side effects of methoxsalen are nausea, vomiting, headache, fever, and diarrhea. Other side effects may include dizziness, stomach cramps, skin rash, and itching. Long-term use of methoxsalen can lead to vision problems, changes in skin color, nail discoloration, and premature aging of the skin.

How Is Vitilen Administered?

Vitilen is usually taken orally (by mouth) in pill form. It may also be used as a topical treatment (applied directly to the skin). When taken orally, it is usually taken one hour before light therapy treatment.

Who Should Not Take Vitilen?

Those who are pregnant, breastfeeding, or have kidney disease should not take methoxsalen. Those with known infections of the skin or cancer (particularly malignant melanoma) should also avoid this treatment. People with a history of eye problems should also not take methoxsalen as it can cause vision damage.

How Long Does It Take For Vitilen to Work?

The length of time it takes for methoxsalen to work depends on several factors such as the severity of your condition, your overall health, and how well you follow your doctor’s instructions. It is important to be patient when taking methoxsalen, as results may take up to several weeks or months.

What Types of Skin Conditions Can Vitilen Treat?

Vitilen is most commonly used to treat psoriasis, vitiligo, and certain types of eczema. It is also sometimes used to treat mycosis fungoides, a form of skin cancer. It can also be used to treat other skin problems that do not respond to traditional treatments.

Are There Any Substitutes for Vitilen?

Some people may be unable or unwilling to take methoxsalen. In these cases, alternative treatments may be available. These may include light therapy (phototherapy) alone, other medications such as retinoids, and lifestyle changes such as avoiding certain triggers.

What Precautions Should I Take When Taking Vitilen?

When taking methoxsalen, it is important to use sunscreen and avoid sun exposure as much as possible. You should also wear protective clothing and eye wear when outside. It is also important to remember that this medication can cause vision damage, so it is important to have a complete eye exam before starting treatment.

Should Vitilen Be Used On Children?

Vitilen should not be used on children unless instructed by a doctor, as its safety and effectiveness in this population have not been established.

What Are the Possible Interactions of Vitilen?

Vitilen may interact with other medications, including antibiotics, anti-inflammatory drugs, antidepressants, blood thinners, and birth control pills. It is important to tell your doctor about all medications you are taking when you are prescribed methoxsalen.

Can I Buy Vitilen Over the Counter?

No, methoxsalen is only available through a prescription from your doctor. It is important to take this medication only as directed and to not exceed the prescribed dose.

Should I Take Vitilen with Food?

Vitilen is usually taken on an empty stomach, one hour before light therapy. Talk to your doctor about any food-related instructions that may be specific to your situation.

Are There any Alternatives to Taking Vitilen?

Yes, there may be alternative treatments available for your skin condition. Talk to your doctor about other options, including light therapy alone or with a topical medication, retinoid medications, and lifestyle changes such as avoiding triggers.

How Long Does Vitilen Last in the System?

Vitilen has a half-life of about 4 hours. This means that it takes about 4 hours for the concentration of the medication in your body to decrease by 50%.

What Should I Do If I Miss a Dose of Vitilen?

If you miss a dose of methoxsalen, it is important to take the missed dose as soon as possible. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and take your next dose at the usual time. Do not double up on doses.

How Do I Store Vitilen?

Vitilen should be stored at room temperature in a dry, dark place away from children and pets. It is also important to keep it away from heat or direct sunlight. It is best to keep the medication in its original container with the safety seal intact.

Is Vitilen Addictive?

No, methoxsalen is not an addictive medication. However, it is important to take it only as directed by a doctor and not to exceed the prescribed dose.

Will Taking Vitilen Make My Skin More Sensitive to Sunlight?

Yes, methoxsalen will make the skin more sensitive to sunlight. It is important to protect yourself from the sun when taking this medication, such as by wearing sunscreen and protective clothing.

Which Sunscreens Are Compatible with Vitilen?

It is best to use sunscreens that are specifically formulated for use with this medication. Talk to your doctor or pharmacist to find out which brands are most compatible with and effective for use with methoxsalen.

Can I Still Go to the Beach or Pool While Taking Vitilen?

It is possible to go to the beach or pool while taking this medication, however, it is important to take extra precautions to protect yourself from the sun’s rays. Wear protective clothing, a wide brimmed hat, and UV-blocking sunglasses. Additionally, use a waterproof sunscreen with at least SPF 15 and reapply frequently.

Should I Wear Sunscreen at Night When Taking Vitilen?

It is important to wear sunscreen during the day when taking this medication, however, it is not necessary to wear sunscreen at night. The medication only makes your skin more sensitive to the sun’s rays, not to sunlight or artificial light in general.

What Should I Do if I Get a Sunburn While Taking Vitilen?

If you get a sunburn while taking methoxsalen, it is important to take some steps to soothe and care for your skin. Take a cool bath or shower, apply a moisturizer, and take an over-the-counter pain reliever. If the sunburn is severe, it is important to see a doctor.

Will Taking Vitilen Make Me More Photosensitive?

Yes, methoxsalen can make the skin more sensitive to the sun’s rays. This is why it is important to take extra precautions when out in the sun, such as wearing protective clothing, using sunscreen, and avoiding direct sun exposure.

Is Vitilen Dangerous if Misused?

Yes, it is important to take methoxsalen only as directed by your doctor and not to exceed the prescribed dose. Taking too much of this medication can cause serious side effects. If you think you have taken too much, contact your doctor immediately.

Are There Any Natural Alternatives to Taking Vitilen?

Yes, there may be natural alternatives to taking methoxsalen. Talk to your doctor about other options, such as lifestyle changes (such as avoiding certain triggers), herbal remedies, and modifications to your diet.

What Should I Do If I Develop an Allergic Reaction to Vitilen?

If you develop any signs of an allergic reaction to methoxsalen, such as hives, difficulty breathing, or swelling of the face or throat, stop taking the medication immediately and contact your doctor.

Does Vitilen Cause Weight Gain?

Weight gain is not listed as a side effect of methoxsalen. However, if you have been experiencing unexplained weight gain while taking this medication, talk to your doctor to rule out any underlying causes or drug interactions.

Can I Take Other Medications While Taking Vitilen?

Yes, you can take other medications as long as they do not interact with methoxsalen. It is important to tell your doctor about all medications you are currently taking to ensure that there are no drug interactions.

Can Vitilen Treat Other Skin Conditions?

Vitilen is most commonly used to treat psoriasis, vitiligo, and certain types of eczema. It can also be used to treat other skin problems that do not respond to traditional treatments, however, it should be used only with doctor's supervision.

Do I Have to Take Vitilen Forever?

No, methoxsalen is usually taken for a few weeks or months, depending on your condition. However, talk to your doctor about how long you should take this medication.

Can Vitilen Cause Hair Loss?

Hair loss is not listed as a side effect of methoxsalen. However, if you are experiencing hair loss or other side effects while taking this medication, it is important to talk to your doctor.

Do I Have to Take Vitilen Every Day?

The frequency with which you take methoxsalen will depend on your individual treatment plan. It is important to follow the instructions of your doctor and take the medication as directed.

How Long Does Light Therapy Take After Taking Vitilen?

The amount of time you spend in light therapy after taking methoxsalen depends on several factors, such as your individual skin condition and the area being treated. On average, light therapy sessions can last up to an hour. Talk to your doctor about the best treatment plan for you.

Should I Avoid Certain Foods When Taking Vitilen?

Some foods may interact with methoxsalen, so it is important to talk to your doctor about any dietary restrictions that may apply to your situation.

Does Vitilen Have Any Impact on Blood Sugar Levels?

Vitilen has not been known to have any effect on blood sugar levels. However, if you have diabetes, it is important to closely monitor your blood sugar levels while taking this medication.

Can I Drink Alcohol While Taking Vitilen?

It is not recommended to drink alcohol while taking this medication. Alcohol can interact with and worsen the side effects of methoxsalen. Therefore, it is best to avoid drinking alcohol while taking this medication.