Tocef

Tocef Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tocef is a brand name. Its generic name is Cefpodoxime.

Introduction

Tocef (also referred to as cefpodoxime proxetil) is an antibiotic used to treat sinus infections, bronchitis, pneumonia, ENT infections, skin infections, and certain urinary tract infections. The drug belongs to a class of antibiotics called cephalosporins and is produced in oral, and intravenous formats.

Uses

Tocef is used to treat a variety of bacterial infections such as sinusitis, bronchitis, pneumonia, otitis media, cellulitis, urinary tract infections, skin and skin structure infections, and pharyngitis/tonsillitis.

Mechanism of Action

Tocef works by inhibiting bacterial cell wall synthesis. This leads to an influx of water and causes the cell wall to rupture, thus killing the bacteria. In addition, the drug has some activity against certain types of fungi, viruses and protozoa.

How Long Does It Take to Work

Tocef usually begins to take effect within 1-2 days of administration. However, it may take up to 5-7 days to experience full relief of symptoms.

Absorption, Route of Elimination, Dosage and Administration

Tocef is rapidly and almost completely absorbed from the gastrointestinal tract. The drug is eliminated primarily through the kidneys and the excretion rate is slow. The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours. Oral suspension formulations are available in 50 and 100 mg/5 mL strengths.

Side Effects

Common side effects of cefpodoxime include diarrhea, nausea, vomiting, abdominal pain, dizziness, headache, fatigue, rash, and skin sensitivity. Severe side effects include anaphylaxis, kidney damage, and fainting. Tocef can also cause abnormal liver function test results and thrombocytopenia.

Toxicity

Tocef is generally well-tolerated. Overdose symptoms include nausea, vomiting, diarrhea, dizziness, rapid heart rate, and rare seizures.

Precautions

Tocef should be avoided in patients with history of allergy to cephalosporins. The drug should not be used in patients with impaired kidney or liver function. It should also be used with caution in pregnant and breastfeeding women.

Interaction

Tocef may interact with other medications such as antacids, warfarin, digoxin, probenecid, and certain drugs for HIV/AIDS, etc. Drugs that interact with cefpodoxime include: paroxetine; phenytoin; ritonavir; certain fluoroquinolone antibiotics such as ciprofloxacin, norfloxacin, and ofloxacin; and certain anti-seizure drugs such as phenytoin, valproic acid, and carbamazepine.

Disease Interaction

Tocef may interact with certain medical conditions such as kidney disease, history of allergic reactions to other cephalosporin antibiotics, and intestinal inflammation due to infection or the use of antibiotics. Tocef should be used with caution in patients with kidney disease. It should not be used in patients if there is an existing intestine infection or if the patient has recently been taking antibiotics.

Drug Interaction

Drug interactions may occur when cefpodoxime is taken with other medications such as antacids, warfarin, probenecid, and certain HIV drugs. Tocef should not be used together with drugs like paroxetine, phenytoin, ritonavir, certain fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin), certain anti-seizure drugs (phenytoin, valproic acid, carbamazepine), etc. Patients should inform their physicians of any medications they are currently taking before taking cefpodoxime.

Food Interactions

Tocef should be taken with a full glass of water. Food can decrease the absorption of cefpodoxime, so the drug should be taken at least 2 hours before or after a meal. Avoid consumption of dairy products, antacids, iron supplements, and vitamins within 2 hours of taking cefpodoxime.

Pregnancy Use

Tocef is likely safe to use during pregnancy. However, it is best to consult a doctor before taking cefpodoxime during pregnancy.

Lactation Use

Tocef is not known to be harmful when breastfeeding. However, it is best to consult a doctor before taking cefpodoxime while breastfeeding.

Acute Overdose

Acute overdose of cefpodoxime can result in nausea, dizziness, rapid heart rate, and seizures. Seek medical help if overdose is suspected.

Contraindication

Tocef is contraindicated in patients with known allergy to cephalosporins.

Dosage Information

The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours.

Direction of Use

Tocef should be taken orally with a full glass of water. It should be taken with or without food. It should not be taken with dairy products, antacids, iron supplements, or vitamins.

Storage Condition

Tocef should be stored in a tight container, away from light and moisture, at room temperature (15-30°C).

Volume of Distribution

Tocef has a volume of distribution of 0.3 - 0.5 L/kg.

Half-Life

The average half-life of cefpodoxime is about 2 - 4 hours.

Clearance

The average clearance of cefpodoxime is 50 - 70 mL/min.

Here you find in details version of Tocef

Some Frequently Asked Questions About Tocef

What is Tocef?

Tocef is an antibiotic used to treat certain types of bacterial infections. It belongs to a class of antibiotics called cephalosporins that work by stopping the growth of bacteria.

What infections does Tocef treat?

Tocef is used to treat infections caused by certain bacteria, such as lower respiratory tract infections, otitis media (middle ear infections), skin infections, and urinary tract infections.

How does Tocef work?

Tocef works by attacking the bacteria that cause the infection. It works by interfering with the bacteria’s ability to make cell walls, which results in the death of the bacteria.

Who should take Tocef?

Tocef should be taken by those who have been prescribed it by a doctor to treat a bacterial infection. It should not be taken by anyone who has an allergy to cephalosporin antibiotics.

How do I take Tocef?

Tocef should be taken as directed by your doctor. The dosage and length of treatment will depend on the infection being treated. The tablets should be taken with a full glass of water. If you forget to take a dose, take it as soon as you remember.

What are the possible side effects of taking Tocef?

Some common side effects of taking Tocef may include nausea, vomiting, diarrhea, or skin rash. Serious side effects include easy bleeding or bruising, yellowing skin or eyes, chest pain, or difficulty breathing. Tell your doctor if you experience any of these side effects.

What if I am allergic to Tocef?

If you are allergic to Tocef or other cephalosporin antibiotics, do not take this drug. Tell your doctor about any allergies that you have before beginning treatment.

Can I take Tocef with other medications?

Before taking Tocef, tell your doctor if you are taking any other medications, especially probenecid, sulfamethoxazole, or valproic acid. Some medications may interact with Tocef, so it is important to discuss them with your doctor before beginning treatment.

Can Tocef be used to treat a viral infection?

No, Tocef is not effective for treating viral infections since it only attacks bacterial infections.

What is the recommended dosage for Tocef?

The recommended dosage of Tocef depends on the infection being treated and on the patient's age and weight. It is important to follow your doctor's instructions when taking Tocef.

Can Tocef be used during pregnancy?

Tocef is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication during pregnancy.

Can I miss a dose of Tocef?

If you miss a dose of Tocef, take it as soon as possible. However, if it is close to the time for your next dose, skip the missed dose and continue with your normal schedule.

Is Tocef safe for children?

Yes, Tocef is safe to use in children. However, it is important to follow your doctor's instructions for dosage and duration of treatment.

Does Tocef have any interactions with food?

No, Tocef does not have any known food interactions.

Can I drink alcohol while taking Tocef?

It is not recommended to drink alcohol while taking Tocef, as it may increase the chance of side effects.

Does Tocef cause headaches?

Tocef can cause headaches as a side effect in some people. If you experience headaches while taking Tocef, contact your doctor.

How long should I take Tocef?

Your doctor will determine how long you should take Tocef. It is important to follow your doctor’s instructions for the duration of treatment.

Can Tocef affect the liver?

Tocef can potentially cause liver damage in rare cases. If you notice any symptoms of liver damage, such as yellowing of the skin or eyes, contact your doctor.

What should I do if I develop an allergic reaction to Tocef?

If you develop an allergic reaction while taking Tocef, stop taking the medication and contact your doctor immediately.

Is Tocef available as a generic drug?

Yes, Tocef is available as a generic drug.

Does Tocef cause drowsiness?

Tocef can cause drowsiness as a side effect in some people. If you experience drowsiness while taking Tocef, contact your doctor.

Can I take Tocef with other antibiotics?

No, Tocef should not be taken with other antibiotics since it can lead to increased side effects and altered effectiveness.

Can Tocef treat sore throats?

No, Tocef is not effective for treating sore throat caused by viral infections.

Can Tocef be used to treat bacterial meningitis?

Yes, Tocef can be used to treat bacterial meningitis.

Can Tocef be used to treat strep throat?

Yes, Tocef can be used to treat strep throat.

Is Tocef available in other forms such as an oral suspension?

Yes, Tocef is also available as an oral suspension.

Can I take Tocef for a long period of time?

It is not recommended to take Tocef for a long period of time, as it can lead to overgrowth of certain bacteria and lead to antibiotic resistance.

Can I take Tocef with ibuprofen?

Yes, Tocef can be taken with ibuprofen.

Is it safe to take Tocef while breastfeeding?

It is not recommended to take Tocef while breastfeeding because it can pass into breast milk and affect the infant. Contact your doctor before taking Tocef while breastfeeding.

Can Tocef be used to treat ear infections?

Yes, Tocef can be used to treat ear infections.

Can Tocef treat urinary tract infections?

Yes, Tocef can be used to treat urinary tract infections.

Is Tocef safe for people with kidney or liver disease?

People with kidney or liver disease should use Tocef with caution, as it is broken down by the kidneys and liver. Talk to your doctor before taking Tocef if you have kidney or liver disease.

Can Tocef make you tired?

Yes, Tocef can cause fatigue as a side effect in some people. Talk to your doctor if you experience fatigue while taking Tocef.

How often do I need to take Tocef?

You should take Tocef as directed by your doctor. The frequency of doses will depend on the infection as well as the patient’s age and weight.

What laboratory tests should be done while taking Tocef?

Your doctor may recommend certain laboratory tests such as a complete blood count, liver function tests, or kidney function tests while taking Tocef.

Can Tocef be used in animals such as cats or dogs?

Yes, Tocef can be used in cats and dogs, but only under the direction of a veterinarian.

What should I do if I miss a dose of Tocef?

If you miss a dose of Tocef, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue on your regular schedule.

What can happen if I take an overdose of Tocef?

If you take an overdose of Tocef, contact your doctor or local poison control center immediately. Symptoms of an overdose may include nausea, dizziness, or difficulty breathing.

Should I avoid activities that require mental alertness while taking Tocef?

Yes, it is best to avoid activities that require mental alertness while taking Tocef because it can cause drowsiness and dizziness as side effects.

Can Tocef cause nausea and vomiting?

Yes, Tocef can cause nausea and vomiting as side effects. Talk to your doctor if you experience nausea and vomiting while taking Tocef.