Tendonil
Tendonil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tendonil is a brand name. Its generic name is Acemetacin.
Tendonil
Tendonil is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation, stiffness, and swelling caused by arthritis and other conditions. It is available in tablets or as an injection, and is generally used in symptomatic treatment for musculoskeletal disorders. Tendonil works by inhibiting prostaglandin synthesis, thereby preventing inflammation and pain.
Uses For
Tendonil is used as a symptomatic treatment for musculoskeletal diseases, including rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve acute gout, mild to moderate pain associated with muscle-skeletal disorders, and soft tissue swelling.
Mechanism of Action
Tendonil works by blocking the action of certain chemical messengers responsible for inflammation, pain and swelling. It does this by inhibiting cyclooxygenase (COX), an enzyme responsible for producing various pro-inflammatory prostaglandins. By blocking COX, acemetacin reduces inflammation and pain.
How Long Does It Take To Work?
For most musculoskeletal disorders, acemetacin typically begins to take effect in 1 to 2 weeks. However, the exact time period may vary depending on the individual and the condition being treated.
Absorption
Tendonil is rapidly absorbed and widely distributed following oral administration. It has an estimated bioavailability of approximately 60-70%.
Route of Elimination
Tendonil is metabolized primarily by the liver. The metabolites are then excreted in the urine and feces.
Dosage
The recommended adult dosage of acemetacin varies from 60-90 mg, taken 2-3 times a day. It should always be taken with food or antacids to reduce the risk of stomach irritation. It is important to note that dosages should be individualized to each patient’s medical condition and response to treatment.
Administration
Tendonil is usually taken orally in tablet form, in a dose of 60-90 mg 2-3 times per day, with food or antacids to reduce the risk of stomach irritation. It can also be injected directly into a muscle or joint, but this route of administration should only be used by a healthcare professional.
Side Effects
Common side effects of acemetacin include nausea, headache, dizziness, rash, stomach pain, and diarrhea. It may also cause stomach ulcers and gastric bleeding in some people. Some people may experience an allergic reaction, with symptom such as fever, difficulty breathing, and swelling of the face, mouth, and throat.
Toxicity
Tendonil is generally considered to be safe when used as directed. Overdose symptoms can include stomach bleeding, difficulty breathing, drowsiness, weakness, and vomiting. If an overdose is suspected, contact a poison control center or emergency room immediately.
Precautions
Tendonil should not be used by people who are allergic to it or to other NSAIDs. It is also not suitable for people with a history of stomach bleeding, kidney disease, or heart failure. It should be used with caution in people with liver or kidney impairment, or those who are pregnant or breastfeeding. Patients should talk to their doctor before taking acemetacin.
Interactions
Tendonil may interact with other medications, including blood thinners, lithium, methotrexate, aspirin, steroids, and diuretics. Alcohol and other NSAIDs should be avoided while taking acemetacin. Patients should tell their doctor about all the medicines they take before starting acemetacin.
Disease Interaction
Tendonil should not be used in people with a history of kidney or liver disease, stomach bleeding, or heart failure. It should also be used with caution in patients with asthma, high blood pressure, or diabetes.
Drug Interaction
Tendonil may interact with other medications, such as blood thinners, lithium, methotrexate, aspirin, steroids, and diuretics. Alcohol and other NSAIDs should be avoided while taking acemetacin. Patients should tell their doctor about all the medicines they take before starting acemetacin.
Food Interactions
Tendonil should be taken with food or antacids to reduce the risk of stomach irritation. Patients should avoid alcohol and other NSAIDs while taking acemetacin.
Pregnancy Use
Tendonil should not be used during pregnancy, unless prescribed by a doctor. It is not known if acemetacin passes into breast milk, so it should not be used while nursing.
Lactation Use
Tendonil should not be used while breastfeeding. It is not known if acemetacin passes into breast milk.
Acute Overdose
Symptoms of an acute overdose may include stomach bleeding, difficulty breathing, drowsiness, weakness, and vomiting. If an overdose is suspected, contact a poison control center or emergency room immediately.
Contraindication
Tendonil is contraindicated in people with a known hypersensitivity to the drug, or to any of its components. It should also not be used in people with a history of kidney or liver disease, stomach bleeding, or heart failure.
Use Direction
Tendonil should be taken according to the prescription or as directed by a doctor. It should be taken with food or antacids to reduce the risk of stomach irritation. The dose may vary from 60-90 mg, taken 2-3 times a day. The duration of treatment should not exceed 4 weeks without consulting a doctor.
Storage Condition
Tendonil tablets should be stored at room temperature, in a cool, dry place away from direct sunlight. The injection should be stored in the refrigerator and should not be frozen.
Volume of Distribution
The estimated volume of distribution for acemetacin is 7.5-10L/kg.
Half Life
The half-life of acemetacin is 0.8-1.7 hours.
Clearance
The estimated clearance of acemetacin is 15-26 mL/min/kg.
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