Sofra Tulle
Sofra Tulle Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sofra Tulle is a brand name. Its generic name is Framycetin.
Introduction
Sofra Tulle, also known as framycetin sulfate, is an antibiotic of the aminoglycoside group. It is used to treat bacterial infections in the body. It is effective against certain gram-positive and gram-negative aerobic bacteria. It is available in both topical and systemic forms.
Uses
Sofra Tulle is used to treat bacterial infections such as skin and soft tissue infections, eye infections, ear infections, and bacterial meningitis. It may also be used before and after surgical procedures to prevent infection.
Mechanism of Action
Sofra Tulle works by inhibiting the growth of bacteria. It binds to bacterial ribosomes and blocks the formation of proteins that are needed for bacterial replication and growth. This prevents the bacteria from multiplying and spreads to other sites in the patient's body.
How Long Does it Take to Work?
Sofra Tulle usually begins to work within 1 hour of administration. Depending on the type and severity of infection, it can take up to a few days for the full effects to take place. The exact time frame depends on the patient's condition and response to the drug.
Absorption
Sofra Tulle is rapidly and completely absorbed after oral or parenteral administration. Peak levels are typically achieved within 1-2 hours. It is widely distributed throughout the body, but the drug does not penetrate into the central nervous system easily.
Route of Elimination
Most of the drug is excreted through the kidneys as unchanged drug and metabolites, which are further metabolised. A small amount is excreted through the bile.
Dosage
The usual recommended dosage of framycetin is 15-30 mg/kg/day given as an intravenous infusion. It can also be given intramuscularly or orally at a dose of 10-30 mg/kg/day. The total daily dosage should be divided into two or three equal doses and administered at evenly spaced intervals.
Administration
Sofra Tulle should always be administered by a healthcare professional. It can be administered intravenously, intramuscularly, or orally. It can also be given topically as an ointment or cream. The dosage and route of administration should be determined by a physician.
Side Effects
Common side effects of framycetin include nausea, vomiting, stomach pain, diarrhea, rash, headache, dizziness, and itching. Less common side effects include hearing loss, kidney damage, allergic reactions, and muscle weakness. If any of these side effects occur, notify your doctor immediately.
Toxicity
Sofra Tulle is highly toxic if overdosed. Signs of overdose include difficulty breathing, confusion, muscle weakness, and seizures. If you suspect an overdose, seek medical help immediately.
Precautions
Before using framycetin, tell your doctor about any other medical conditions you may have, any medications you are taking, and any allergies you have. This drug should not be used by pregnant women or nursing mothers. It should also not be used in patients with known hypersensitivity to the drug.
Interactions
Sofra Tulle may interact with other medications such as drugs used to treat seizures, certain antibiotics, tacrolimus, antacids, vitamins, and other drugs. Before using this drug, tell your doctor about all the medications you are taking in order to avoid any potential interactions.
Disease Interaction
Patients with certain medical conditions may be at an increased risk of experiencing side effects when taking framycetin. These include patients with kidney or liver disease, muscular dystrophy, myasthenia gravis, or hearing loss.
Drug Interactions
Sofra Tulle can interact with certain other medications. These include drugs used to treat seizures, certain antibiotics, tacrolimus, antacids, vitamins, and other drugs. Tell your doctor about any medications you are taking in order to avoid any potential interactions.
Food Interactions
It is important to avoid certain foods while taking framycetin as some foods can interact with the drug. These include foods high in calcium and magnesium such as dairy products, antacids, and multivitamins. It is also important to avoid alcohol while taking this medication.
Pregnancy Use
Sofra Tulle should not be used by pregnant women. It may cause harm to an unborn baby. It is also not known if this medication passes into breast milk, so it should be avoided by nursing mothers.
Lactation Use
Sofra Tulle should not be used by nursing mothers. It is not known if the medication passes into breast milk, so it should be avoided.
Acute Overdose
An overdose of this medication can be fatal. Signs of overdose include difficulty breathing, confusion, muscle weakness, and seizures. Seek medical help immediately if you think that you or someone else may have overdosed.
Contraindication
Sofra Tulle should not be used in patients with known hypersensitivity to the drug. It should also not be used by pregnant women or nursing mothers.
Use Directions
Sofra Tulle should be used exactly as directed by your doctor. Do not use more or less of the medication than prescribed and avoid skipping doses. Inform your doctor if your condition does not improve or worsens. Follow all directions on the prescription label and read all medication guides or instruction sheets.
Storage Conditions
Sofra Tulle should be stored at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Volume of Distribution
Sofra Tulle has an average volume of distribution of 0.42 L/kg. It distributes widely throughout the body, but does not penetrate into the central nervous system easily.
Half Life
The average half-life of framycetin is 0.8-2.5 hours. This means that the drug is cleared from the body in about two hours.
Clearance
Sofra Tulle has an average total clearance of 0.26 L/h/kg. It is mainly cleared by the kidneys as unchanged drug and metabolites.
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