Selecox
Selecox Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Selecox is a brand name. Its generic name is Celecoxib.
Introduction
Selecox, also known as Celebrex, is an NSAID medication used to treat various conditions of inflammation and pain. Commonly used to treat arthritis, Selecox works by inhibiting the enzyme COX-2, reducing inflammation and decreasing pain.
Uses
Selecox is commonly used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, menstrual pain, and pain caused by inflammation (such as that associated with injuries). It is also used to reduce the number of colorectal polyps in people with familial adenomatous polyposis.
Mechanism of Action
Selecox works by inhibiting the COX-2 enzyme, which is responsible for the production of several pro-inflammatory mediators in the body. By blocking the action of this enzyme, the amount of these mediators is reduced, leading to decreased inflammation and pain.
How Long Does It Take to Work?
The effects of Selecox usually begin within 3-4 days of taking the medication. It may take up to two weeks to feel the full effects of the medication.
Absorption
Selecox is rapidly and extensively absorbed from the gastrointestinal tract after oral administration.
Route of Elimination
Selecox is eliminated in the feces and urine. About 80% of an administered dose is recovered in feces as unchanged drug, metabolites, and biliary excretion products. About 30% of the drug is eliminated unchanged in the urine.
Dosage
The recommended adult dose for Selecox is 200-400 mg taken twice daily. The maximum daily dose is 800 mg. Dosage should be adjusted in patients with impaired kidney function.
Administration
Selecox should be taken with a full glass of water and should be taken on an empty stomach.
Side Effects
Common side effects of Selecox include nausea, stomach pain, diarrhea, dizziness, constipation, gas, heartburn, drowsiness, headache, and rash. Some serious side effects may include swelling of the face, hands, feet, ankles, stomach pains, chest pain, and difficulty breathing.
Toxicity
Selecox is generally well tolerated. However, Selecox can cause serious side effects if taken in high doses and when used for long periods of time. The risk of serious side effects increases with the duration of treatment.
Precautions
Patients taking Selecox should be aware of the potential risk for stomach ulcers and bleeding. Patients should also be aware of the risk of hypersensitivity reactions and kidney impairment associated with this medication.
Interaction
Selecox can interact with other medications, including inhibitors of cytochrome P-450 isoenzymes, antibiotics, antifungals, antihypertensives, anticonvulsants, and some corticosteroids. Before using Selecox, consult your doctor or pharmacist.
Disease Interaction
Patients with heart failure, high blood pressure, blood clotting disorders, or an allergy to NSAIDs should not take Selecox. Patients with a pre-existing bleeding disorder, bleeding ulcer, or liver disease should use Selecox with caution.
Drug Interactions
Selecox may interact with a number of drugs, including warfarin, lithium, methotrexate, ACE inhibitors, and corticosteroids. Consult your doctor or pharmacist for a complete list of drug interactions.
Food Interactions
Alcohol should be avoided while taking Selecox. Other foods high in fat may increase the rate of absorption of the medication.
Pregnancy Use
Selecox is contraindicated in pregnant women. Other NSAIDs should be considered in pregnant women to avoid risk.
Lactation Use
Selecox is contraindicated in breastfeeding women. Other NSAIDs should be considered in breastfeeding women to avoid risk.
Acute Overdose
In case of acute overdose, seek medical attention immediately. Symptoms may include confusion, vomiting, rash, stomach pain, and breathing difficulty.
Contraindication
Selecox is contraindicated in pregnant women and breastfeeding women. Selecox is also contraindicated in patients with a history of hypersensitivity reaction to Selecox or any other NSAID.
Use Direction
Selecox should be taken as directed by your health care provider. It should be taken with a full glass of water, and should be taken on an empty stomach. Do not exceed the recommended dosage.
Storage Condition
Selecox should be stored at room temperature away from direct sunlight and heat. Keep out of reach of children.
Volume of Distribution
The average volume of distribution for Selecox is approximately 17 L/kg.
Half Life
The average half-life of Selecox is approximately 11 hours.
Clearance
The clearance for Selecox is approximately 0.4 L/hr/kg.
Here you find in details version of Selecox
Some Frequently Asked Questions About Selecox
What is Selecox?
Selecox is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and stiffness caused by arthritis and some other conditions. It is sold under the brand names Celebrex and Celebra.
How does Selecox work?
Selecox is an anti-inflammatory drug that works by inhibiting the production of prostaglandins, substances that cause inflammation. This reduction in prostaglandins helps reduce pain and inflammation in patients with arthritis and other conditions.
What is the difference between Selecox and other NSAIDs?
Selecox is a newer generation of NSAIDs that are less likely to cause stomach irritation and bleeding. It is also less likely to cause kidney damage than traditional NSAIDs. It is commonly used for the treatment of arthritis and other painful conditions.
What are the side effects of Selecox?
Common side effects of Selecox include stomach upset, nausea, diarrhea, headache, and dizziness. Less common but more serious side effects include liver and kidney damage, increased risk of bleeding or stroke, and allergic reactions.
Is Selecox safe to use long-term?
Selecox is generally considered safe to use long-term, however it can increase risk of certain side effects such as stomach irritation and an increased risk of stroke or bleeding. Talk to your doctor to make sure Selecox is right for you.
Can Selecox be crushed or split in half?
No, Selecox should not be crushed or split in half. Taking the whole capsule at once is the only safe way to take this medication.
What should be avoided while taking Selecox?
Alcohol should be avoided while taking Selecox, as it can increase the risk of stomach bleeding. You should also avoid using other medications including NSAIDs and steroids without talking to your doctor first, as they can increase the risk of side effects.
Is Selecox safe to use during pregnancy and breastfeeding?
No, Selecox should not be used during pregnancy or breastfeeding. If you are pregnant or think you might be pregnant, talk to your doctor before taking celecoxib.
Can Selecox interact with other medications?
Yes, Selecox can interact with other medications including NSAIDs, steroids, blood thinners, and some antibiotics. Talk to your doctor or pharmacist before starting or changing medications to make sure Selecox is right for you.
How do you take Selecox?
Selecox should be taken exactly as your doctor or healthcare provider has prescribed. Do not take more or less than what is recommended. The usual recommended dose is 200 mg once or twice daily. It should be taken with food to reduce stomach irritation.
What should I do if I miss a dose of Selecox?
If you miss a dose of Selecox, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
How long does it take for Selecox to start working?
It can take up to a few weeks for Selecox to start working. If your symptoms do not improve after 4-6 weeks, talk to your doctor, as the dose may need to be adjusted.
Is Selecox habit forming?
No, Selecox is not habit forming. However, it is important to take the medication as prescribed and not to stop taking it without talking to your doctor first.
Is Selecox safe to use in children?
Selecox is not approved for use in children. Talk to your doctor before giving your child Selecox.
Can Selecox cause weight gain?
No, Selecox does not typically cause weight gain, however some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Selecox.
Should I take Selecox with food?
Yes, Selecox should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
Is Selecox addictive?
No, Selecox is not an addictive medication. However, it is important to take it as prescribed and not to stop taking it without talking to your doctor first.
Can Selecox cause liver damage?
Yes, there is a risk of liver damage with long-term use of Selecox. Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time.
Can Selecox be used for pain relief?
Yes, Selecox is often used to treat pain and inflammation associated with arthritis and other conditions. Talk to your doctor to make sure Selecox is right for you.
Should Selecox be taken with other medications?
Selecox can interact with many other medications. Talk to your doctor or pharmacist before starting or changing medications to make sure Selecox is right for you.
Does Selecox interact with birth control?
Yes, there is a potential for Selecox to interact with birth control pills, leading to an increased risk of side effects. Talk to your doctor about safer alternatives for contraception if you take this medication.
Can Selecox cause stomach pain?
Yes, some patients taking Selecox may experience stomach pain. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
Can Selecox cause drowsiness?
Yes, drowsiness is a possible side effect of Selecox. Talk to your doctor if you experience excessive drowsiness while taking this medication.
Can Selecox cause erectile dysfunction?
Yes, erectile dysfunction is a possible side effect of Selecox. Talk to your doctor immediately if you experience any changes in your sexual function while taking this medication.
Can I take Selecox and ibuprofen together?
No, taking both Selecox and ibuprofen at the same time can increase your risk of stomach irritation and bleeding. Make sure to tell your doctor if you are already taking any other medications.
Should I take Selecox with food or on an empty stomach?
Selecox should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
Does Selecox cause hair loss?
No, hair loss is not a common side effect of Selecox. Talk to your doctor right away if you experience any changes in your hair while taking this medication.
Can Selecox cause an allergic reaction?
Yes, allergic reactions to Selecox are possible. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, and swelling. Contact your doctor immediately if you experience any of these symptoms while taking this medication.
Can Selecox cause constipation?
Yes, constipation is a possible side effect of Selecox. If you experience constipation while taking this medication, talk to your doctor about ways to manage it.
Can Selecox be used to treat fever?
No, Selecox is not typically used to treat fever. Talk to your doctor about other options for treating fever.
Is Selecox a blood thinner?
No, Selecox is not a blood thinner. However, it can increase your risk of bleeding when taken with other blood thinning medications. Talk to your doctor before taking Selecox with other medications.
Can Selecox cause nausea?
Yes, nausea is a possible side effect of Selecox. Talk to your doctor if you experience nausea while taking this medication.
Can Selecox cause dehydration?
Yes, dehydration is a possible side effect of Selecox. Make sure to drink plenty of fluids while taking this medication, especially if you are experiencing other symptoms such as nausea, vomiting, and diarrhea.
Can Selecox cause stomach upset?
Yes, stomach upset is a possible side effect of Selecox. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
What is the maximum daily dose of Selecox?
The maximum recommended daily dose of Selecox is 400 mg. Taking more than this can increase your risk of side effects. Talk to your doctor if you are prescribed a higher dose.
How long can I take Selecox?
The maximum recommended duration of use of Selecox is six months. Talk to your doctor if you need to take this medication for longer than this, as it can increase your risk of side effects.
Does Selecox cause dizziness?
Yes, dizziness is a common side effect of Selecox. If you experience dizziness while taking this medication, talk to your doctor about ways to manage it.
Should I take Selecox with food or milk?
Selecox should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
Does Selecox reduce inflammation?
Yes, Selecox is an anti-inflammatory drug that helps reduce inflammation by inhibiting the production of prostaglandins. This can reduce pain and inflammation in patients with arthritis and other conditions.
Does Selecox cause weight gain?
No, weight gain is not typically caused by Selecox. However, some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Selecox.
Can Selecox cause fatigue?
Yes, fatigue is a possible side effect of Selecox. Talk to your doctor if you experience fatigue while taking this medication.
Can Selecox cause heartburn?
Yes, heartburn is a possible side effect of Selecox. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.
Do I need to have regular blood tests while taking Selecox?
Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time. Talk to your doctor about any other tests you may need while using Selecox.