Sefril DS
Sefril DS Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sefril DS is a brand name. Its generic name is Cefradine.
Introduction
Sefril DS is an antibiotic drug commonly used for treatment of infections caused by bacteria. It is a first-generation cephalosporin and belongs to the class of cephalosporins. It is a semi-synthetic antibiotic, which means that it has been made in a laboratory from natural substances.
Uses for
Sefril DS is used to treat a variety of infections, including but not limited to respiratory infections, skin infections, chest infections, urinary tract infections, and some sexually transmitted diseases.
Mechanism of Action
Sefril DS works by inhibiting the bacteria's ability to make proteins which are an important part of its structure, function, and multiplication. By inhibiting this process, cefradine is able to kill the bacteria and prevent it from multiplying.
How Long Does it Take to Work?
Sefril DS usually starts to work within a few hours of taking the medication. However, depending on the type of infection being treated, it can take up to several days before the symptoms start to clear up.
Absorption
Sefril DS is mostly absorbed from the gastrointestinal tract, with the exception of the dose taken rectally. The majority of an oral dose is absorbed within 3 hours, with peak plasma concentrations occurring after 4-6 hours.
Route of Elimination
Sefril DS is eliminated largely from the urine as the unchanged form. Some is also excreted in the feces via biliary excretion. The half-life is in the range of 1-2 hours.
Dosage
Sefril DS is available in the form of tablets, capsules, and soluble tablets. The usual adult dosage ranges from 500mg to 1000mg twice daily, depending on the severity of the infection being treated.
Administration
Sefril DS should be taken orally with a glass of water, preferably one hour before or two hours after meals, or as directed by the healthcare provider. It is important not to take cefradine with food as this interferes with absorption. For rectal administration, the dose should be dissolved in a small amount of water.
Side Effect
Common side effects of cefradine include nausea, vomiting, abdominal pain, diarrhea, skin rash, oral thrush, and vaginal itching. More serious side effects include anemia, jaundice, fever, and seizures.
Toxicity
Sefril DS is generally safe and well tolerated at the recommended dosage. Overdose can lead to symptoms such as renal failure, seizures, and blood disorders.
Precautions
Sefril DS should be used with caution in patients with liver or kidney disease, and in those taking other medications such as anticoagulants, oral contraceptives, and diuretics. It should also be used with caution in pregnant and breastfeeding women.
Interactions
Sefril DS may interact with other drugs and should not be taken in combination with other antibiotics, sedatives, or anticoagulants. It also interacts with some herbs and supplements, including ginkgo biloba, garlic, and St. John's Wort.
Disease Interaction
Sefril DS has been known to interact with certain diseases, including kidney and liver disease, which may affect its effectiveness or cause side effects. It may also interact with other diseases, such as diabetes, which can alter its metabolism and increase its potential for side effects.
Drug Interactions
Sefril DS may interact with other drugs including anticoagulants, oral contraceptives, and diuretics. Taking cefradine simultaneously with these drugs may increase the risk of side effects. Additionally, cefradine may increase the risk of bleeding when taken with other drugs that increase blood clotting time.
Food Interactions
Sefril DS should be taken one hour before or two hours after meals. Taking it simultaneously with food may reduce its effectiveness. It should also not be taken with dairy products, including milk, cheese, and yogurt, as this may reduce its absorption rate.
Pregnancy Use
Sefril DS should be used with caution in pregnant women. There is limited evidence regarding the safety of cefradine during pregnancy. If used, the lowest effective dosage should be used for the shortest duration possible.
Lactation Use
Sefril DS should be avoided during lactation as it is excreted in breast milk. If it must be used, the lowest effective dosage should be used for the shortest duration possible.
Acute Overdose
If an overdose is suspected, the patient should be taken to the doctor or hospital immediately. Symptoms of an overdose include nausea, vomiting, abdominal pain, drowsiness, convulsions, and sweating.
Contraindication
Sefril DS is contraindicated in patients with a known hypersensitivity to cephalosporins or penicillins. It is also contraindicated in patients with severe renal or hepatic impairment, and in those who have had a previous episode of either anaphylactic or anaphylactoid reactions.
Use Direction
Sefril DS should always be taken as prescribed by the doctor. The dosing frequency and duration of treatment should not be altered without consulting the healthcare provider.
Storage Condition
Sefril DS should be stored at room temperature in a closed container, away from moisture and direct sunlight. Keep out of reach of children and pets.
Volume of Distribution
Sefril DS has a volume of distribution of 0.3-0.6 L/kg indicating a low penetration into tissues.
Half Life
The elimination half-life of cefradine is in the range of 1-2 hours.
Clearance
Sefril DS is mainly eliminated by the kidneys with an average clearance of 250mL/min.
Here you find in details version of Sefril DS
Some Frequently Asked Questions About Sefril DS
What is Sefril DS?
Sefril DS is a type of antibiotic medicine that is used to treat bacterial infections.
How does Sefril DS work?
Sefril DS works by preventing bacteria from forming cell walls, which are necessary for the bacteria to survive and grow.
What type of infections can Sefril DS treat?
Sefril DS is used to treat bacterial infections such as skin and soft tissue infections, urinary tract infections, and respiratory tract infections.
Who should not take Sefril DS?
Sefril DS should not be taken by people who are allergic to cephalosporin antibiotics. People with kidney, liver, or intestinal disease should consult a doctor before taking this medicine.
What are the possible side effects of Sefril DS?
The most common side effects of Sefril DS are nausea, vomiting, diarrhea, skin rash, and headache.
Is Sefril DS safe to take during pregnancy?
Sefril DS is generally considered safe to take during pregnancy, however it is recommended that pregnant women should consult their doctor before taking it.
What should I do if I experience any side effects from Sefril DS?
If you experience any side effects, you should stop taking the medication and consult your doctor immediately.
How and when should I take Sefril DS?
Sefril DS should be taken with food or a full glass of water/milk. The amount and duration of treatment will depend on the type and severity of your infection.
What should I do if I miss a dose of Sefril DS?
If you miss a dose of Sefril DS, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule.
Is it safe to consume alcohol while taking Sefril DS?
It is not recommended to consume alcohol while taking Sefril DS as it may increase the risk of side effects such as nausea, dizziness, drowsiness, and reduced alertness.
Can I take other medicines while taking Sefril DS?
Some medicines may interact with Sefril DS and it is recommended to consult your doctor before taking any other medication.
Can Sefril DS be used for children?
Sefril DS can be used for children but it is important to consult a doctor before giving this medicine to a child.
Are there any foods I should avoid while taking Sefril DS?
No, you do not need to avoid any specific foods while taking Sefril DS.
How long does it take for Sefril DS to work?
It may take up to 2 weeks for Sefril DS to work and start relieving symptoms.
Can I stop taking Sefril DS once I start to feel better?
No, it is important to continue taking Sefril DS until you have finished the course of medication prescribed by your doctor.
What should I do if I am taking Sefril DS and experience a fever?
If you experience a fever while taking Sefril DS, you should contact your doctor as soon as possible.
Does Sefril DS interact with birth control pills?
Yes, Sefril DS may interact with birth control pills. It is recommended to consult your doctor for advice.
Does Sefril DS interact with other antibiotics?
Yes, some antibiotics may interact with Sefril DS. It is recommended to consult your doctor for advice before taking any other medication.
Should I take Sefril DS with food or on an empty stomach?
Sefril DS should be taken with food or a full glass of water/milk.
Can Sefril DS be used to treat a sore throat?
Yes, Sefril DS is used to treat sore throat caused by bacterial infections.
Can I take Sefril DS to prevent an infection?
No, Sefril DS should not be taken as a preventative measure against infections.
Is Sefril DS affected by hot weather?
No, Sefril DS is not affected by hot weather.
Can Sefril DS be taken with vitamin supplements?
Yes, Sefril DS can be taken with vitamin supplements, however it is recommended to consult your doctor before taking any additional supplements.
What should I do if I experience an allergic reaction to Sefril DS?
If you experience an allergic reaction to Sefril DS, stop taking the medication and contact your doctor immediately.
Can I take Sefril DS with antacids?
Yes, Sefril DS can be taken with antacids, however it is recommended to consult your doctor for advice.
Can I take Sefril DS if I am breastfeeding?
It is not recommended to take Sefril DS while breastfeeding, however it is recommended to consult your doctor for advice.
Can I take Sefril DS while menstruating?
Yes, you can take Sefril DS while menstruating.
What should I do if I experience nausea after taking Sefril DS?
If you experience nausea after taking Sefril DS, it is recommended to consult your doctor for advice.
Can Sefril DS interact with other medications?
Yes, some medications may interact with Sefril DS and it is recommended to consult your doctor before taking any other medication.
What should I do if I experience vomiting after taking Sefril DS?
If you experience vomiting after taking Sefril DS, it is recommended to consult your doctor for advice.
Can I take Sefril DS if I am diabetic?
Yes, Sefril DS can be taken if you are diabetic, however it is recommended to consult your doctor for advice.
Can I take Sefril DS if I have a kidney condition?
Yes, Sefril DS can be taken if you have a kidney condition, however it is recommended to consult your doctor for advice.
Can I take Sefril DS if I have a liver condition?
Yes, Sefril DS can be taken if you have a liver condition, however it is recommended to consult your doctor for advice.
Is there any age restriction for taking Sefril DS?
No, there is no age restriction for taking Sefril DS, however it is recommended to consult your doctor for advice.
Can Sefril DS cause dizziness?
Yes, Sefril DS can cause dizziness, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause drowsiness?
Yes, Sefril DS can cause drowsiness, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause dehydration?
Yes, Sefril DS can cause dehydration, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause reduced alertness?
Yes, Sefril DS can cause reduced alertness, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause a burning sensation?
Yes, Sefril DS can cause a burning sensation, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause headaches?
Yes, Sefril DS can cause headaches, and it is recommended to consult your doctor if you experience this symptom.
Can Sefril DS cause stomach cramps?
Yes, Sefril DS can cause stomach cramps, and it is recommended to consult your doctor if you experience this symptom.