Meverine

Meverine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Meverine is a brand name. Its generic name is Mebeverine.

Meverine Introduction

Meverine is an antispasmodic drug which is used to relax the muscles in the digestive system. Meverine hydrochloride is the hydrochloride salt of an ethylenediamine derivative, mebeverine. It is used in the symptomatic treatment of gastrointestinal spasm associated with irritable bowel syndrome. It helps to reduce symptoms such as stomach cramps, abdominal pain, and irregular and painful bowel movements.

Uses For

Meverine is used to treat cramps or spasms of the stomach and intestines. It is also used to treat irritable bowel syndrome.

Mechanism of Action

Meverine works to relax the muscles at the level of the stomach and intestine walls to help reduce abdominal pain, cramps, and irritable bowel syndrome (IBS). It acts on muscarinic receptors (cholinergic receptors) within the intestines, slowing the rate of muscle contraction. This slows the passage of food through the digestive system, increasing the absorption of water through the bowels and ultimately alleviating cramps, pain, and other IBS symptoms.

How Long Does It Take To Work?

Meverine usually starts to work within 1-2 hours of taking the tablet, although in some cases it may take up to 3 days to feel the full effect.

Absorption

Meverine is rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved 1 to 2 hours after administration. Meverine has a bioavailability of approximately 90%; it is not significantly influenced by food.

Route of Elimination

Meverine is eliminated by hepatic metabolism to inactive metabolites. The metabolites are excreted mainly in the urine.

Dosage

Meverine is available as tablets or as capsules that can be taken orally. Usual adult dosage is 135 mg three times per day between meals, and the usual dosage for children is 20-45 mg three times per day between meals.

Administration

Meverine should be taken with a glass of water before meals, with meals or after meals. It can be taken with or without food. It is important to take mebeverine on a regular basis and at the same time each day as this will help the patient to remember to take it and increase the chances of receiving the maximum benefit.

Side Effect

Common side effects of mebeverine include headache, nausea, abdominal pain, and dizziness. Rare side effects include severe allergic reactions (anaphylactic reaction), Stevens-Johnson syndrome, increased tear production, blurred vision, chest pain, and difficulty breathing.

Toxicity

Meverine is generally well tolerated and has a low toxicity profile. In animal studies, the LD50 is shown to be greater than 12g/kg body weight.

Precaution

Patients should inform their doctor of any other medications they take, as well as any history of asthma, eczema or an allergy, or any other allergies (e.g. food allergies). Meverine should be used cautiously in patients with a history of seizures, kidney or liver disease, or a certain type of intestinal obstruction.

Interaction

Meverine may interact with certain medications like antacids, digoxin, warfarin, and metoclopramide. Patients should inform their doctor of all medications taken prior to taking mebeverine as these could interact and increase the risk of side effects occurring.

Disease Interaction

Meverine is not suitable for use by patients with a tachycardia, hypersensitivity to mebeverine, or bladder/intestinal obstruction.

Drug Interaction

Meverine may interact with certain medications such as antacids, digoxin, warfarin, and metoclopramide, increasing the risk of side effects.

Food Interactions

Meverine is not known to interact with food. However, it may interact with foods high in tyramine such as aged cheese, yogurt, smoked fish, and certain beers or wines.

Pregnancy Use

Meverine is not recommended for use during pregnancy. It is not known if mebeverine can pass into breast milk, but it is unlikely to cause harm to a nursing infant.

Lactation Use

Meverine is not recommended for use while breastfeeding as it is not known if mebeverine can pass into breast milk and cause harm to an infant.

Acute Overdose

In case of an acute overdose of mebeverine, doctors may recommend gastric lavage, activated charcoal and supportive measures in order to absorb and eliminate the drug.

Contraindication

Meverine is contraindicated in patients with a known sensitivity or allergy to mebeverine, other lincomycin antibiotics, or any of the other ingredients in the product.

Use Direction

Meverine tablets should be taken orally, with a glass of water before, with, or after meals. Do not take more than the prescribed dose or exceed the recommended frequency.

Storage Condition

Meverine should be stored at room temperature in a dry, dark place away from heat and direct sunlight. Keep it in a tightly sealed container, away from children and pets.

Volume of Distribution

The volume of distribution of mebeverine is 4.8 L/kg.

Half Life

The elimination half-life of mebeverine is 7 hours.

Clearance

The clearance of mebeverine is 116 ml/min/1.73 m2.

Here you find in details version of Meverine

Some Frequently Asked Questions About Meverine

What is Meverine?

Meverine is a medication used to treat irritable bowel syndrome (IBS), and inflammatory bowel disease (such as ulcerative colitis and Crohn's disease). It works by slowing down the movement of the muscles in the intestine, which helps reduce pain and cramping.

How does Meverine work?

Meverine works by decreasing the contractile activity of the muscles in the intestine which helps reduce pain and cramping that is associated with irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease).

What are the side effects of Meverine?

The most common side effects associated with taking mebeverine include nausea, vomiting, constipation, and headache. Other possible side effects include dry mouth, insomnia, nervousness, dizziness, diarrhoea, and skin rash.

Do I need a prescription for Meverine?

Yes, Meverine is a prescription medication and must be obtained from your doctor or healthcare provider.

How should Meverine be taken?

Meverine should be taken exactly as prescribed by your doctor or healthcare provider. Do not change your dose or stop taking Meverine without first consulting with your healthcare provider.

Is Meverine safe?

Yes, Meverine is generally considered safe when taken as prescribed by a medical professional. However, there may be certain side effects associated with taking Meverine. Check with your doctor or healthcare provider for more information.

Can I take Meverine with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

How long does it take for Meverine to work?

The effects of Meverine can be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Meverine are experienced.

Is Meverine a narcotic?

No, Meverine is not a narcotic and does not have any mind-altering or psychoactive properties.

Can Meverine be used for other purposes?

Meverine is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Meverine for any other purpose than what is prescribed by your doctor or healthcare provider.

Can Meverine be taken with food?

It is recommended to take Meverine with food or shortly after eating. Taking Meverine with food will help reduce the risk of stomach upset and other side effects.

Can I drink alcohol while taking Meverine?

It is not recommended to consume alcohol while taking Meverine. Consuming alcohol may increase the risk of side effects or decrease the effectiveness of the medication.

Is Meverine habit forming?

No, Meverine is not habit-forming and does not produce any type of physical or psychological dependence.

What should I do if I miss a dose?

If you miss a dose of Meverine, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed dose.

What should I do if I overdose on Meverine?

If you think you have overdosed on Meverine, seek immediate medical attention. Overdosing on Meverine can cause serious side effects and should be treated as soon as possible.

What are the possible interactions with Meverine?

It is important to tell your doctor or healthcare provider about any medications, supplements, or herbal remedies you are taking before starting treatment with Meverine. Certain medications, supplements, or herbal remedies may interact with the medication and increase the risk of side effects.

Can Meverine be used during pregnancy?

There is limited data available on the use of Meverine during pregnancy and it should be used only when clearly needed. Pregnant women should consult with their doctor or healthcare provider to determine the risks and benefits of taking Meverine during pregnancy.

Can Meverine be used while breast-feeding?

There is no data available on the use of Meverine while breast-feeding and it should be used only when clearly needed. Women who are breast-feeding should consult with their doctor or healthcare provider to determine the risks and benefits of taking Meverine while breast-feeding.

Should I take Meverine every day?

Meverine should be taken as prescribed by your doctor or healthcare provider. Generally it is taken 3 times per day, preferably with meals. Do not take more or less than the recommended dose, and do not stop taking the medication without consulting your doctor or healthcare provider.

Can I stop taking Meverine without consulting my doctor?

No, it is not recommended to stop taking Meverine without first consulting with your doctor or healthcare provider. Abruptly stopping Meverine may worsen your symptoms and lead to other complications.

When will I notice improvement in my symptoms?

The effects of Meverine may be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Meverine are experienced.

Is Meverine safe for long-term use?

Meverine is generally considered safe for long-term use, when taken as prescribed by a medical professional. However, it is important to tell your doctor if you experience any side effects or if your symptoms worsen while taking Meverine.

Can Meverine be used in children?

Meverine is not recommended for use in children under 12 years of age. Children who are 12 years and older should take Meverine only as directed by their doctor or healthcare provider.

Can I take Meverine with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

Are there any allergies associated with Meverine?

It is not known if people who are allergic to Meverine will have an allergic reaction to other medications. Check with your doctor or healthcare provider about any allergies you may have, or if you are taking any medications for any allergies.

What flavours of Meverine are available?

Meverine is available in tablets, capsules, and syrup form. The tablets and capsules are available in various flavours, including berry, lemon, orange and vanilla.

Are there any other conditions that I should tell my doctor about before taking Meverine?

Yes, it is important to tell your doctor about any other medical conditions you may have, as these may affect the way Meverine works. Make sure to tell your doctor about allergies, any other medications you are taking, or any other medical conditions you may have.

Should I take Meverine if I have a history of liver disease?

It is not recommended to take Meverine if you have a history of liver disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

What should I do if I experience any unusual symptoms while taking Meverine?

If you experience any unusual symptoms while taking Meverine, such as dizziness, nausea, fatigue and difficulty breathing, contact your doctor or healthcare provider immediately. Do not stop taking Meverine without first consulting with your doctor or healthcare provider.

Can I take Meverine with antacids?

It is not recommended to take Meverine with antacids, as antacids may decrease the effectiveness of the medication. Talk to your doctor or healthcare provider about suitable alternatives.

Can I take Meverine with other IBS medications?

It is important to tell your doctor or healthcare provider about all medications you are taking, including any IBS medications, before starting treatment with Meverine. Certain medications may interact with Meverine and increase the risk of side effects.

What should I do if I experience any stomach pain while taking Meverine?

If you experience any stomach pain while taking Meverine, it is important to contact your doctor or healthcare provider immediately. Do not stop taking Meverine without first consulting with your doctor or healthcare provider.

Can I take Meverine with antidepressants?

It is important to tell your doctor or healthcare provider about all medications you are taking before starting treatment with Meverine. Certain medications, including antidepressants, may interact with Meverine and increase the risk of side effects.

Can Meverine be used to treat other conditions than irritable bowel syndrome (IBS) and inflammatory bowel diseases (ulcerative colitis and Crohn's disease)?

No, Meverine is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Meverine for any other purpose than what is prescribed by your doctor or healthcare provider.

Is Meverine available over-the-counter?

No, Meverine is a prescription medication and must be obtained from your doctor or healthcare provider.

Can I take Meverine if I have a history of kidney disease?

Meverine is not recommended for people with a history of kidney disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

Are there any age restrictions for taking Meverine?

Meverine is not recommended for children under 12 years of age. Children who are 12 years and older should take Meverine only as directed by their doctor or healthcare provider.

How should I store Meverine?

Meverine should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep out of the reach of children and pets.