Meberine SR

Meberine SR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Meberine SR is a brand name. Its generic name is Mebeverine.

Meberine SR Introduction

Meberine SR is an antispasmodic drug which is used to relax the muscles in the digestive system. Meberine SR hydrochloride is the hydrochloride salt of an ethylenediamine derivative, mebeverine. It is used in the symptomatic treatment of gastrointestinal spasm associated with irritable bowel syndrome. It helps to reduce symptoms such as stomach cramps, abdominal pain, and irregular and painful bowel movements.

Uses For

Meberine SR is used to treat cramps or spasms of the stomach and intestines. It is also used to treat irritable bowel syndrome.

Mechanism of Action

Meberine SR works to relax the muscles at the level of the stomach and intestine walls to help reduce abdominal pain, cramps, and irritable bowel syndrome (IBS). It acts on muscarinic receptors (cholinergic receptors) within the intestines, slowing the rate of muscle contraction. This slows the passage of food through the digestive system, increasing the absorption of water through the bowels and ultimately alleviating cramps, pain, and other IBS symptoms.

How Long Does It Take To Work?

Meberine SR usually starts to work within 1-2 hours of taking the tablet, although in some cases it may take up to 3 days to feel the full effect.

Absorption

Meberine SR is rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved 1 to 2 hours after administration. Meberine SR has a bioavailability of approximately 90%; it is not significantly influenced by food.

Route of Elimination

Meberine SR is eliminated by hepatic metabolism to inactive metabolites. The metabolites are excreted mainly in the urine.

Dosage

Meberine SR is available as tablets or as capsules that can be taken orally. Usual adult dosage is 135 mg three times per day between meals, and the usual dosage for children is 20-45 mg three times per day between meals.

Administration

Meberine SR should be taken with a glass of water before meals, with meals or after meals. It can be taken with or without food. It is important to take mebeverine on a regular basis and at the same time each day as this will help the patient to remember to take it and increase the chances of receiving the maximum benefit.

Side Effect

Common side effects of mebeverine include headache, nausea, abdominal pain, and dizziness. Rare side effects include severe allergic reactions (anaphylactic reaction), Stevens-Johnson syndrome, increased tear production, blurred vision, chest pain, and difficulty breathing.

Toxicity

Meberine SR is generally well tolerated and has a low toxicity profile. In animal studies, the LD50 is shown to be greater than 12g/kg body weight.

Precaution

Patients should inform their doctor of any other medications they take, as well as any history of asthma, eczema or an allergy, or any other allergies (e.g. food allergies). Meberine SR should be used cautiously in patients with a history of seizures, kidney or liver disease, or a certain type of intestinal obstruction.

Interaction

Meberine SR may interact with certain medications like antacids, digoxin, warfarin, and metoclopramide. Patients should inform their doctor of all medications taken prior to taking mebeverine as these could interact and increase the risk of side effects occurring.

Disease Interaction

Meberine SR is not suitable for use by patients with a tachycardia, hypersensitivity to mebeverine, or bladder/intestinal obstruction.

Drug Interaction

Meberine SR may interact with certain medications such as antacids, digoxin, warfarin, and metoclopramide, increasing the risk of side effects.

Food Interactions

Meberine SR is not known to interact with food. However, it may interact with foods high in tyramine such as aged cheese, yogurt, smoked fish, and certain beers or wines.

Pregnancy Use

Meberine SR is not recommended for use during pregnancy. It is not known if mebeverine can pass into breast milk, but it is unlikely to cause harm to a nursing infant.

Lactation Use

Meberine SR is not recommended for use while breastfeeding as it is not known if mebeverine can pass into breast milk and cause harm to an infant.

Acute Overdose

In case of an acute overdose of mebeverine, doctors may recommend gastric lavage, activated charcoal and supportive measures in order to absorb and eliminate the drug.

Contraindication

Meberine SR is contraindicated in patients with a known sensitivity or allergy to mebeverine, other lincomycin antibiotics, or any of the other ingredients in the product.

Use Direction

Meberine SR tablets should be taken orally, with a glass of water before, with, or after meals. Do not take more than the prescribed dose or exceed the recommended frequency.

Storage Condition

Meberine SR should be stored at room temperature in a dry, dark place away from heat and direct sunlight. Keep it in a tightly sealed container, away from children and pets.

Volume of Distribution

The volume of distribution of mebeverine is 4.8 L/kg.

Half Life

The elimination half-life of mebeverine is 7 hours.

Clearance

The clearance of mebeverine is 116 ml/min/1.73 m2.

Here you find in details version of Meberine SR

Some Frequently Asked Questions About Meberine SR

What is Meberine SR?

Meberine SR is a medication used to treat irritable bowel syndrome (IBS), and inflammatory bowel disease (such as ulcerative colitis and Crohn's disease). It works by slowing down the movement of the muscles in the intestine, which helps reduce pain and cramping.

How does Meberine SR work?

Meberine SR works by decreasing the contractile activity of the muscles in the intestine which helps reduce pain and cramping that is associated with irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease).

What are the side effects of Meberine SR?

The most common side effects associated with taking mebeverine include nausea, vomiting, constipation, and headache. Other possible side effects include dry mouth, insomnia, nervousness, dizziness, diarrhoea, and skin rash.

Do I need a prescription for Meberine SR?

Yes, Meberine SR is a prescription medication and must be obtained from your doctor or healthcare provider.

How should Meberine SR be taken?

Meberine SR should be taken exactly as prescribed by your doctor or healthcare provider. Do not change your dose or stop taking Meberine SR without first consulting with your healthcare provider.

Is Meberine SR safe?

Yes, Meberine SR is generally considered safe when taken as prescribed by a medical professional. However, there may be certain side effects associated with taking Meberine SR. Check with your doctor or healthcare provider for more information.

Can I take Meberine SR with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

How long does it take for Meberine SR to work?

The effects of Meberine SR can be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Meberine SR are experienced.

Is Meberine SR a narcotic?

No, Meberine SR is not a narcotic and does not have any mind-altering or psychoactive properties.

Can Meberine SR be used for other purposes?

Meberine SR is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Meberine SR for any other purpose than what is prescribed by your doctor or healthcare provider.

Can Meberine SR be taken with food?

It is recommended to take Meberine SR with food or shortly after eating. Taking Meberine SR with food will help reduce the risk of stomach upset and other side effects.

Can I drink alcohol while taking Meberine SR?

It is not recommended to consume alcohol while taking Meberine SR. Consuming alcohol may increase the risk of side effects or decrease the effectiveness of the medication.

Is Meberine SR habit forming?

No, Meberine SR is not habit-forming and does not produce any type of physical or psychological dependence.

What should I do if I miss a dose?

If you miss a dose of Meberine SR, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed dose.

What should I do if I overdose on Meberine SR?

If you think you have overdosed on Meberine SR, seek immediate medical attention. Overdosing on Meberine SR can cause serious side effects and should be treated as soon as possible.

What are the possible interactions with Meberine SR?

It is important to tell your doctor or healthcare provider about any medications, supplements, or herbal remedies you are taking before starting treatment with Meberine SR. Certain medications, supplements, or herbal remedies may interact with the medication and increase the risk of side effects.

Can Meberine SR be used during pregnancy?

There is limited data available on the use of Meberine SR during pregnancy and it should be used only when clearly needed. Pregnant women should consult with their doctor or healthcare provider to determine the risks and benefits of taking Meberine SR during pregnancy.

Can Meberine SR be used while breast-feeding?

There is no data available on the use of Meberine SR while breast-feeding and it should be used only when clearly needed. Women who are breast-feeding should consult with their doctor or healthcare provider to determine the risks and benefits of taking Meberine SR while breast-feeding.

Should I take Meberine SR every day?

Meberine SR should be taken as prescribed by your doctor or healthcare provider. Generally it is taken 3 times per day, preferably with meals. Do not take more or less than the recommended dose, and do not stop taking the medication without consulting your doctor or healthcare provider.

Can I stop taking Meberine SR without consulting my doctor?

No, it is not recommended to stop taking Meberine SR without first consulting with your doctor or healthcare provider. Abruptly stopping Meberine SR may worsen your symptoms and lead to other complications.

When will I notice improvement in my symptoms?

The effects of Meberine SR may be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Meberine SR are experienced.

Is Meberine SR safe for long-term use?

Meberine SR is generally considered safe for long-term use, when taken as prescribed by a medical professional. However, it is important to tell your doctor if you experience any side effects or if your symptoms worsen while taking Meberine SR.

Can Meberine SR be used in children?

Meberine SR is not recommended for use in children under 12 years of age. Children who are 12 years and older should take Meberine SR only as directed by their doctor or healthcare provider.

Can I take Meberine SR with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

Are there any allergies associated with Meberine SR?

It is not known if people who are allergic to Meberine SR will have an allergic reaction to other medications. Check with your doctor or healthcare provider about any allergies you may have, or if you are taking any medications for any allergies.

What flavours of Meberine SR are available?

Meberine SR is available in tablets, capsules, and syrup form. The tablets and capsules are available in various flavours, including berry, lemon, orange and vanilla.

Are there any other conditions that I should tell my doctor about before taking Meberine SR?

Yes, it is important to tell your doctor about any other medical conditions you may have, as these may affect the way Meberine SR works. Make sure to tell your doctor about allergies, any other medications you are taking, or any other medical conditions you may have.

Should I take Meberine SR if I have a history of liver disease?

It is not recommended to take Meberine SR if you have a history of liver disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

What should I do if I experience any unusual symptoms while taking Meberine SR?

If you experience any unusual symptoms while taking Meberine SR, such as dizziness, nausea, fatigue and difficulty breathing, contact your doctor or healthcare provider immediately. Do not stop taking Meberine SR without first consulting with your doctor or healthcare provider.

Can I take Meberine SR with antacids?

It is not recommended to take Meberine SR with antacids, as antacids may decrease the effectiveness of the medication. Talk to your doctor or healthcare provider about suitable alternatives.

Can I take Meberine SR with other IBS medications?

It is important to tell your doctor or healthcare provider about all medications you are taking, including any IBS medications, before starting treatment with Meberine SR. Certain medications may interact with Meberine SR and increase the risk of side effects.

What should I do if I experience any stomach pain while taking Meberine SR?

If you experience any stomach pain while taking Meberine SR, it is important to contact your doctor or healthcare provider immediately. Do not stop taking Meberine SR without first consulting with your doctor or healthcare provider.

Can I take Meberine SR with antidepressants?

It is important to tell your doctor or healthcare provider about all medications you are taking before starting treatment with Meberine SR. Certain medications, including antidepressants, may interact with Meberine SR and increase the risk of side effects.

Can Meberine SR be used to treat other conditions than irritable bowel syndrome (IBS) and inflammatory bowel diseases (ulcerative colitis and Crohn's disease)?

No, Meberine SR is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Meberine SR for any other purpose than what is prescribed by your doctor or healthcare provider.

Is Meberine SR available over-the-counter?

No, Meberine SR is a prescription medication and must be obtained from your doctor or healthcare provider.

Can I take Meberine SR if I have a history of kidney disease?

Meberine SR is not recommended for people with a history of kidney disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

Are there any age restrictions for taking Meberine SR?

Meberine SR is not recommended for children under 12 years of age. Children who are 12 years and older should take Meberine SR only as directed by their doctor or healthcare provider.

How should I store Meberine SR?

Meberine SR should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep out of the reach of children and pets.