Invigen (IV Infusion)

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By Beximco Pharmaceuticals Ltd.

Weight: 80 mg/100 ml

Unit Price: 66.11

Last Updated: 2019-09-01 15:34:07

Invigen IV Infusion Uses

Gentamicin is indicated in the following conditions:

  • Septicemia and neonatal sepsis
  • Meningitis and other CNS infections
  • Serious bacterial infections of Urinary tract, Respiratory tract, Gastrointestinal tract (including peritonitis), Skin, Bone & Soft tissue (including Burns)
  • Biliary tract infections
  • Acute pyelonephritis or prostatitis
  • Endocarditis caused by Strep. viridans or Strep. faecalis
  • Pneumonia in hospital patient
  • Adjunct in listerial meningitis
  • Brucellosis, Cat scratch disease, Cystic fibrosis, Endometritis, Listeriosis, Otitis media , Otitis externa, Peritonitis, Plague
  • Prophylaxis of surgical infections and the treatment of immunocompromised patients and those in intensive care

Invigen Generic

Gentamicin (Intravenous Infusion)

Invigen Introduction

Gentamicin is the most important of the aminoglycosides and is widely used for the treatment of serious infections. It is bactericidal and active against some Gram-positive and many Gram-negative organisms. It is active against Pseudomonas aeruginosa, Proteus sp. E. coli, Klebsiella-Enterobacter-Serratia sp. Citrobacter sp. and Staphylococcus sp. Gentamicin interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits resulting in a defective bacterial cell membrane.

Invigen Therapeutic Class

Antibacterial drugs

Invigen IV Infusion Doses

The daily dose is 2-5 mg/kg in divided doses every 8 hours. The standard adult dose is 100 ml to be administered over 20 minutes, 8 hourly or as prescribed by the physician. Whenever possible treatment should not exceed 7 days. Higher doses are occasionally indicated for serious infections, especially in the neonates or the compromised hosts. The interval between doses and even the dose itself may be modified if there is impairment of renal function or high pre-dose plasma concentration (pre-dose 'trough' concentration should be less than 2 mg/L).

Child:

  • Up to 2 weeks: 3 mg/kg every 12 hours
  • 2 weeks-12 years: 2 mg/kg every 8 hours

Invigen Administrations

Invigen IV Infusion Side Effects

Vestibular and auditory damage, nephrotoxicity, rarely hypomagnesaemia on prolonged therapy, pseudomembranous colitis, neuromuscular blockade, blood dyscrasia.

Invigen Precaution

In renal impaired patients, infants and elderly adjust dose and monitor renal, auditory and vestibular functions together with plasma Gentamicin concentration. Plasma concentration monitoring avoids both excessive and sub-therapeutic concentrations thus preventing toxicity and ensuring efficacy. Avoid prolonged use.Infusion of fluid should immediately be discontinued if rigor arises from any reason during the process. Do not use if the solution is cloudy, contains particles or after expiry date.

Invigen Interaction

Aminoglycosides should not be given with potentially ototoxic diuretics (e.g. frusemide and ethacrynic acid). Concurrent use of other nephrotoxic drugs including other aminoglycosides, vancomycin and some of the cephalosporins may increase the risk of toxicity. Care is also required if other drugs with a neuromuscular blocking action are given concomitantly.

Invigen Uses During Pregnancy

 

Invigen Accute Overdose

 

Invigen Contraindication

Hypersensitivity to Gentamicin, pregnancy, myasthenia gravis.

Invigen Uses Direction

The intravenous administration of Gentamicin may be particularly useful for treating patients with bacterial septicemia or those in shock. It may also be the preferred route of administration for some patients with congestive heart failure, hematologic disorders, severe burns or those with reduced muscle mass.

Administration Procedure:

  • Check infusion set and infusion solution prior to use.
  • Pull moderately to tear off the protective cover of the Eurohead of the bottle.
  • Close the roller clamp of the giving set.
  • Remove the cover of plastic lancet.
  • Punch the lancet into the container.
  • Hang the bottle upside down.
  • Open the roller clamp to take out the solution in order to expel air.
  • Close the roller clamp firmly.
  • Remove the protective cover of the needle.
  • Locate the venipuncture site and clean the site with an antiseptic solution.
  • Puncture the vein-needle into the patient’s vein.
  • Securely tape the puncture site.
  • Securely tape the wings and tubing.
  • Start infusion while adjusting flow rate by loosening the roller clamp.

Invigen Storage Condition

Gentamicin should be stored at controlled room temperature and protected from light. This intravenous infusion is not intended for multi-dose use.

Invigen Special Warning

 

Invigen Interactions with other Medicine