জি কুইনাইন এ আছে Quinine Sulfate। জি কুইনাইন এর কাজঃ

জি কুইনাইন, is an antimalarial drug indicated only for treatment of uncomplicated Plasmodium falciparum malaria. Quinine sulfate has been shown to be effective in geographical regions where resistance to chloroquine has been documented 

জি কুইনাইন oral capsules are not approved for:

  • Treatment of severe or complicated P. falciparum malaria.
  • Prevention of malaria.
  • Treatment or prevention of nocturnal leg cramps

Quinine Dihydrochloride is indicated for the acute treatment of malaria. It may also be used in the treatment of Babesiosis in conjunction with clindamycin.

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G Quinine Injection 300 mg/5 ml in bangla
ব্র্যান্ড নাম জি কুইনাইন
জেনেরিকঃ Quinine Sulfate
পরিমাপঃ 300 mg/5 ml
ধরণঃ ইনজেকশন
চিকিৎসাগত শ্রেণিঃ Anti-malarial drugs
উৎপাদনকারীঃ Gonoshasthaya Pharmaceuticals Ltd
দামঃ 14.57
সর্বশেষ সম্পাদনাঃ 2020-11-22 18:15:00
পরিচিতি

Quinine is a cinchona alkaloid and a 4-methanolquinoline. It rapidly acts on blood schizontocide by interfering with lysosomal function or nucleic acid synthesis in the Plasmodia spp. It has no activity against exoerythrocytic forms.

খাওয়ার নিয়ম

জি কুইনাইন এ আছে Quinine Sulfate 300 mg/5 ml। জি কুইনাইন খাওয়ার নিয়ম নিম্নরূপঃ

Intravenous:

  • Adult: Initially, 20 mg/kg to max 1.4 g over 4 hr with maintenance infusion started after 8 hr. Maintenance infusions: 10 mg/kg to max 700 mg over 4 hr 8 hrly. Loading dose should not be given if patient has received quinine, quinidine, halofantrine or mefloquine during the previous 24 hr.
  • Child: ≤5 mg/kg/hr by slow IV infusion.

Oral:

  • Adult: 648 mg given every 8 hr for 7 days.
  • Child: ≥8 yr 10 mg/kg 8 hrly for 7 days.

Should be taken with food. Take with food to minimise GI discomfort.

Reconstitutions

Dilute in NaCl 0.9% to a concentration of diHCl 60-100 mg/mL.

পার্শ্বপ্রতিক্রিয়া

Headache, nausea, disturbed vision, impaired hearing, tinnitus, abdominal pain, vomiting, diarrhoea, vertigo; flushing skin with intense pruritus, urticaria; fever, dyspnoea, agranulocytosis, palpitations, rashes; myalgia, muscle weakness, asthma, asthenia, disorientation, angioedema; haemoglobinuria; hypoprothrombinaemia, hypoglycaemia, hypotension, renal failure.

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সতর্কতা

Patients with cardiac conduction defects, heart block or AF. Pregnancy and lactation.

প্রতিক্রিয়া

Reduced renal clearance of amantadine. Reduced clearance with cimetidine. Increased anticoagulant effect of warfarin and other anticoagulants. Reduced plasma levels of ciclosporin. Increased plasma levels of digoxin. Increased risk of myopathy and rhabdomyolysis with atorvastatin. May enhance hypoglycaemic effects of oral antidiabetics.

গর্ভকালীন কিংবা দুগ্ধদানকালীন অবস্থায় ব্যবহার

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

প্রতিনির্দেশনা

Hypersensitivity to quinine, mefloquine or quinidine. Patients with nocturnal leg cramps; prolonged QT interval, tinnitus or optic neuritis, myasthenia gravis, G6PD deficiency, haemolysis and who had suffered from blackwater fever. Concomitant use with ritonavir, mefloquine, rifampicin, class IA and class III antiarrhythmic agents, neuromuscular blocking agents, other drugs known to cause QT prolongation, and Al- and/or Mg-containing antacids.

বিশেষ সতর্কতা

Renal Impairment:

  • Oral:Severe: Initially, 648 mg followed after 12 hr by maintenance doses of 324 mg 12 hrly.
  • Intravenous: Severe: Reduce maintenance dose to 5-7 mg/kg of quinine salt 8 hrly.

Hepatic Impairment:

  • Mild to moderate: No dosage adjustment needed.
  • Intravenous: Severe: Reduce maintenance dose to 5-7 mg/kg of quinine salt 8 hrly.
মাত্রাতিরিক্ত সেবনের প্রতিক্রিয়া

Symptoms: GI effects, CNS disturbances, oculotoxicity, cardiotoxicity,; tinnitus, abdominal pain, diarrhoea, vertigo, pulmonary oedema, hypotension, sweating, flushing, nausea, vomiting, headache, slightly disturbed vision, deafness, vasodilatation and adult resp distress syndrome.

Management: Administer multiple dose of activated charcoal within 1 hr or perform gastric lavage. Symptomatic (e.g. maintaining BP, respiration and renal function, treating arrhythmias) and supportive treatment.

অন্যান্য ঔষধের সাথে প্রতিক্রিয়া

 

সংরক্ষণ

Store between 20-25° C. Protect from light.

জি কুইনাইন ইনজেকশন এর দাম 14.57

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