Delfavir
Delfavir Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Delfavir is a brand name. Its generic name is Efavirenz.
Introduction
Delfavir (marketed under the brand name Sustiva) is a non-nucleoside reverse transcriptase (RT) inhibitor used in combination with other antiretroviral drugs to treat HIV-1 infection. It is a major drug component of highly-active antiretroviral therapy (HAART) for HIV-1 patients.Uses for
Delfavir is used in combination with other antiretroviral drugs to treat HIV-1 infection. It is also used in combination with other antiretroviral drugs to prevent the spread of HIV-1 from mothers to their children.Mechanism of Action
Delfavir inhibits the enzyme reverse transcriptase (RT), which is essential for the reproduction of the HIV-1 virus. In a healthy cell, RT converts the single-stranded RNA genome of HIV-1 back into double-stranded DNA so it can enter the nucleus and integrate into the host genome. By preventing RT from working, Delfavir prevents the HIV-1 virus from replicating.How Long Does It Take To Work?
Within the first 48 hours, Delfavir can significantly reduce the amount of HIV-1 in the body. If taken consistently and as prescribed, Delfavir can help keep HIV-1 levels in check and reduce the risk of developing resistance to HIV-1 medications. However, it is important to note that HIV-1 does not get cured by taking Delfavir.Absorption
Delfavir is readily and rapidly absorbed (Tmax, 2-4 hours) from the gastrointestinal tract and has an absolute bioavailability of 31-51%. The peak plasma concentration of an 600 mg oral dose occurs at 1.77-2.81 hours. The extent of absorption decreases when the tablets are taken with meals.Route of Elimination
Delfavir is primarily eliminated by hepatic metabolism, with approximately 20% of total plasma radioactivity excreted in the urine and bile.Dosage
The usual recommended adult dose is 600mg once daily. Delfavir is available as a 600mg film coated tablet and a 200mg/60mL oral suspension. The tablets should be taken with meals while the suspension should be taken without food. For patients unable to swallow tablets, the tablets can be disrupted in a glass containing a teaspoon of water. The tablets can also be dispersed in a teaspoon of applesauce. Both the tablet suspension and applesauce should be taken immediately.Administration
Delfavir should be taken orally once daily as prescribed. It should be taken with or without food at approximately the same time each day. Patients with renal impairment or severe hepatic impairment should receive a reduced dose of 400 mg once daily.Side Effect
Common side effects of efavirenz include headache, dizziness, insomnia, depression, abnormal dreams, nausea, vomiting and rash.Toxicity
Delfavir has a low toxicity in humans and animals and is generally well tolerated. Side effects in humans are usually mild and can be managed with supportive measures.Precaution
Delfavir may cause drowsiness, confusion, dizziness, and impaired judgment, so caution is advised when engaging in activities that require mental alertness. Delfavir is not recommended for patients with a history of clinically relevant depression. Patients with a history of psychiatric disorders should be monitored for any worsening of their condition.Interaction
Delfavir may interact with other medications, vitamins, and herbal supplements. It is important to notify your healthcare provider before taking any other medications or supplements while on efavirenz.Disease Interaction
Delfavir may interact with certain diseases and medical conditions. It is important to notify your healthcare provider of any medical conditions you may have before taking efavirenz.Drug Interaction
Delfavir may interact with other medications, including certain antibiotics, antifungals, and antiretrovirals. It is important to notify your healthcare provider of any medications you are taking before starting efavirenz.Food Interactions
Delfavir may interact with certain foods, vitamins, and herbal supplements. It is important to avoid taking any food or supplements while taking efavirenz, as it may reduce its effectiveness or cause unwanted side effects.Pregnancy Use
Delfavir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Women should consult their healthcare provider for more information.Lactation Use
It is not known if efavirenz is secreted in breast milk. Women should consult their healthcare provider for more information before taking efavirenz while breastfeeding.Acute Overdose
Acute overdoses of efavirenz can lead to vomiting, nausea, dizziness, and drowsiness. If an overdose is suspected, seek medical help immediately.Contraindication
Delfavir is contraindicated in patients with a history of hypersensitivity to any of its components.Use Directions
Delfavir should be taken as prescribed by your healthcare provider. The usual recommended adult dose is 600mg once daily. The tablets should be taken with meals while the suspension should be taken without food. Patients with renal impairment or severe hepatic impairment should receive a reduced dose of 400 mg once daily.Storage Condition
Delfavir should be stored at room temperature in a tightly closed container, away from heat and moisture. Keep out of the reach of children and pets.Volume of Distribution
The volume of distribution of efavirenz is 0.9-2.3 L/kg.Half Life
The half-life of efavirenz is 41-58 hours.Clearance
The elimination clearance of efavirenz is 0.32-0.56 mL/min/kg.Here you find in details version of Delfavir
Some Frequently Asked Questions About Delfavir
then complete question and give its answerWhat is Delfavir?
Delfavir is an antiretroviral medication used to treat HIV. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Delfavir works by blocking the activity of an enzyme called reverse transcriptase, which is needed by the HIV virus to replicate. As a result, it helps to reduce the amount of HIV virus in the body, which can help to improve a person’s immune system and overall health.
Can Delfavir be used to prevent HIV?
No, Delfavir is not recommended or approved for use as a preventative medication to guard against HIV infection.
What are the possible side effects of Delfavir?
The most common side effects associated with Delfavir are dizziness, sleep disturbances, vivid dreams, and depression. Other less common side effects reported include rash, liver problems, dizziness, headache, nausea, vomiting, diarrhea, and changes in blood tests.
What should I do if I miss a dose of Delfavir?
If you miss a dose of Delfavir, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take the following dose at the regular time.
Can I drink alcohol while taking Delfavir?
No, you should not drink alcohol during treatment with Delfavir as it may lead to an increased risk of side effects or decreased effectiveness of the medication.
Is it safe to use Delfavir during pregnancy?
Yes, Delfavir has been studied in pregnant women and found to be safe for both the mother and the baby. However, it is important to speak to your doctor about the risks and benefits of taking Delfavir during pregnancy.
Can Delfavir be used with other medications?
Yes, Delfavir can be used together with other medications that are prescribed by your healthcare provider. However, it is important to let your healthcare provider know about all of the medications you are taking, as some may interact with Delfavir.
Is there a generic version of Delfavir available?
Yes, Delfavir is available in a generic form. Generic medications are typically less expensive than brand name drugs and are usually just as effective.
What should I do if I experience an allergic reaction to Delfavir?
If you experience any signs of an allergic reaction, such as hives, swelling of the face, throat, or lips, difficulty breathing, or chest tightness, stop taking Delfavir and seek medical attention immediately.
Can Delfavir be used to treat other diseases?
No, Delfavir is not indicated for use in the treatment of other diseases. It is only approved to be used in the treatment of HIV infections.
What is the recommended dose of Delfavir?
The recommended dose of Delfavir depends on several factors, including a person’s weight, other medications being taken, and any pre-existing illnesses. Your healthcare provider can determine the best dose for you.
How long does it take for Delfavir to start working?
Clinical studies have shown that it can take up to four weeks after starting Delfavir therapy for a person’s HIV viral load to become undetectable. During this time, it is important to continue to take the medication as prescribed by your healthcare provider.
Can I stop taking Delfavir if my HIV viral load is undetectable?
No, it is important to continue to take Delfavir as prescribed by your healthcare provider, even if your HIV viral load becomes undetectable. Stopping Delfavir can increase the risk of HIV levels in the body increasing again.
Will taking Delfavir cure HIV?
No, taking Delfavir will not cure HIV. However, it can be used to help control the virus and improve a person’s immune system and overall health.
Does Delfavir have any drug interactions?
Yes, there are certain drugs that can interact with Delfavir, including certain antifungal medications, antidepressants, antibiotics, and birth control pills. It is important to tell your healthcare provider about all medications that you are taking, as some of these could interact with Delfavir.
Can Delfavir cause liver problems?
Yes, hepatotoxicity is a potential side effect of Delfavir. It is important to monitor liver enzymes if taking Delfavir, as liver problems can occur.
What should I do if I experience excessive tiredness while using Delfavir?
If you experience excessive tiredness while taking Delfavir, contact your healthcare provider. This could be a sign of anemia or other conditions that may need to be addressed.
What should I do if I experience depression while using Delfavir?
If you experience depression while taking Delfavir, contact your healthcare provider. Depression can be a serious side effect and may need to be managed differently.
Should I have regular viral load tests while taking Delfavir?
Yes, it is important to have periodic viral load tests while taking Delfavir to make sure that the medication is working effectively. It is also important to practice safe sex and avoid sharing needles, as these can increase your risk of contracting HIV.
Can Delfavir cause gastrointestinal side effects?
Yes, gastrointestinal side effects such as nausea, vomiting, and diarrhea have been reported with Delfavir. It is important to contact your healthcare provider if you experience these side effects.
Are there any laboratory tests that need to be done while taking Delfavir?
Yes, it is important to have regular laboratory tests while taking Delfavir, such as complete blood count, kidney and liver function tests, and viral load tests. Your healthcare provider can explain the tests that need to be done.
Does Delfavir interact with hormonal birth control?
Yes, Delfavir can interact with hormonal birth control, including combination birth control pills, patches, and rings. It is important to let your healthcare provider know if you are on hormonal birth control, as an alternative form of birth control may need to be used.
Can I take Delfavir with other HIV medications?
Yes, Delfavir can be used together with other medications that are prescribed by your healthcare provider. It is important to tell your healthcare provider about all of the medications you are taking, as some may interact with Delfavir.
What should I do if I experience stomach pain while taking Delfavir?
If you experience stomach pain while taking Delfavir, contact your healthcare provider. This could be a sign of a more serious side effect or an interaction with other medications and should be evaluated.
Can I drive or operate machinery while taking Delfavir?
It is not recommended to drive or operate machinery while taking Delfavir, as it can cause dizziness and impair your judgment. If you experience any side effects that make it difficult for you to perform your daily activities, contact your healthcare provider.
Does Delfavir affect fertility in men?
Yes, Delfavir may affect sperm production and sperm motility. It is important to talk to your healthcare provider before taking Delfavir if you are trying to father a child.
Does Delfavir interact with herbal supplements?
Yes, some herbal supplements can interact with Delfavir. It is important to tell your healthcare provider about all of the medications, herbal supplements, and vitamins you are taking before taking Delfavir.
Should I take Delfavir with food?
Yes, Delfavir should be taken with food. Taking it with food can help to reduce the risk of gastrointestinal side effects.
Will Delfavir interact with other medications, such as antibiotics or antifungals?
Yes, there are certain medications, such as antibiotics and antifungals, that can interact with Delfavir. It is important to tell your healthcare provider about all medications that you are taking, as some may interact with Delfavir.
Can I take Delfavir with other HIV medications?
Yes, Delfavir can be used together with other medications that are prescribed by your healthcare provider. It is important to let your healthcare provider know about all of the medications you are taking, as some may interact with Delfavir.
What should I do if I experience vivid dreams while taking Delfavir?
Vivid dreams are a common side effect of Delfavir. If you experience vivid dreams, contact your healthcare provider. In some cases, a lower dose of Delfavir may be prescribed to help reduce the frequency of these dreams.
Is there an alternative to Delfavir for treating HIV?
Yes, there are other medications available for the treatment of HIV. It is important to talk to your healthcare provider about your treatment options.
Can I take Delfavir with anti-inflammatory medications?
Yes, you can take Delfavir with anti-inflammatory medications. However, it is important to tell your healthcare provider about all medications that you are taking, as some may interact with Delfavir.
Does Delfavir have any long-term side effects?
Yes, long-term use of Delfavir may cause anemia, liver toxicity, kidney problems, and changes in liver enzymes. It is important to talk to your healthcare provider about any long-term side effects you may be experiencing.
Is there an alternative to Delfavir for people with liver problems?
Yes, there are alternatives to Delfavir for people with liver problems. It is important to talk to your healthcare provider about your treatment options.
Should I eat a high-fat diet when taking Delfavir?
No, it is not recommended to eat a high-fat diet when taking Delfavir. Eating a balanced diet is the best way to ensure that Delfavir is used most effectively.
Does Delfavir cause weight gain?
Yes, weight gain has been reported with Delfavir. It is important to talk to your healthcare provider about any sudden weight gain that may be related to Delfavir.
Can I take Delfavir if I have kidney problems?
Yes, Delfavir can be taken if you have kidney problems, but your healthcare provider may need to adjust your dose. It is important to talk to your healthcare provider about any kidney problems before taking Delfavir.
Can I take Delfavir with other medications for HIV, such as tenofovir and emtricitabine?
Yes, Delfavir can be taken with other medications that are prescribed by your healthcare provider for the treatment of HIV. It is important to tell your healthcare provider about all of the medications you are taking, as some may interact with Delfavir.
Will Delfavir cause any changes in my mental health?
Yes, mental health side effects such as depression, anxiety, and insomnia have been reported with Efav