Clearon
Clearon Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Clearon is a brand name. Its generic name is Deferasirox.
Clearon Introduction
Clearon (Exjade) is an oral iron chelator developed and marketed by Novartis. It is used to reduce the amount of iron in the body, specifically in those with chronic iron overload due to regular red blood cell transfusions. It acts by removing excess iron from the body, preventing further tissue damage caused by iron accumulation, which can lead to organ damage and death.Clearon Uses
Clearon is used to treat chronic iron overload in adults and children 6 years of age and older who have received frequent blood transfusions to treat certain types of anemia (low red blood cell count). It is also used to treat elevated levels of iron in the blood caused by blood transfusions or by taking medications that contain iron or vitamin A.Clearon Mechanism of Action
Clearon works by binding to iron and forming a compound that can be eliminated through the urine. The drug is rapidly absorbed from the GI tract and enters the circulatory system, where it is distributed to various organs. Once in the organs, the drug binds to iron and forms a complex that can be eliminated through the urine.How Long Does It Take to Work?
Clearon takes effect in 4 to 6 weeks after beginning the drug. It may take several months or longer before the full benefits of the drug are experienced.Clearon Absorption
Clearon is well absorbed from the GI tract after oral administration. It has a bioavailability of about 75%.Clearon Route of Elimination
The drug is excreted from the body primarily in the urine. Some of the drug is excreted in the feces as well.Clearon Dosage
The recommended starting dose of Clearon is 10 mg per kg of body weight once daily. The dose may be increased as needed based on the patient’s response and tolerability of the drug. The maximum recommended dose is 30 mg per kg of body weight per day.Clearon Administration
Clearon tablets should be taken whole and not crushed or chewed. The tablets should be taken with a full glass of water. tablets should be taken at the same time each day.Clearon Side Effects
Common side effects of Clearon include headache, dizziness, nausea, vomiting, diarrhea, rash, and itching.Clearon Toxicity
Clearon is generally well tolerated at the recommended doses. At higher doses, the drug may cause serious side effects, including liver and kidney damage, abnormal heart rhythms, and allergic reactions.Clearon Precaution
Patients taking Clearon should be closely monitored for signs of liver and kidney damage. Patients should also be monitored for signs of anemia. Patients should be advised to take the medication as prescribed and to not exceed the recommended dose.Clearon Interaction
Clearon may interact with other medications including anticoagulants, anithyroid medications, and medications used to treat cancer.Clearon Disease Interaction
Clearon should not be used in patients with certain conditions, such as anemia, hypoproteinemia, and low white blood cell counts. The drug can also lower the blood supply to the kidney or liver, which can increase the risk for developing life-threatening infections.Clearon Drug Interaction
Clearon may interact with other medications including anticoagulants, anithyroid medications, and medications used to treat cancer. Patients should tell their healthcare provider about all the medications and supplements they are taking.Clearon Food Interactions
Food does not appear to significantly affect the absorption or effectiveness of Clearon when taken with or without food.Clearon Pregnancy Use
Clearon should not be used during pregnancy unless the benefits outweigh the risks. It is not known if deferasirox passes into breast milk.Clearon Lactation Use
It is not known if deferasirox passes into breast milk. Clearon should not be used during lactation unless the benefits outweigh the risks.Clearon Acute Overdose
Symptoms of an acute overdose may include nausea, vomiting, dizziness, and abdominal pain. Treatment of an overdose may include supportive care, including observation, and symptomatic management.Clearon Contraindication
Clearon should not be used in patients with severe kidney or liver dysfunction or in those with an allergy or hypersensitivity to the drug or any of its components.Clearon Use Directions
Clearon should be taken as directed by the healthcare provider. The tablets should be taken whole and not crushed or chewed, and with a full glass of water. The tablets should be taken at the same time every day.Clearon Storage Condition
Clearon tablets should be stored at room temperature and away from moisture and light.Clearon Volume of Distribution
The volume of distribution for deferasirox is approximately 10 liters.Clearon Half Life
The half-life of deferasirox is approximately 17 hours.Clearon Clearance
The clearance of deferasirox is approximately 42 mL/min.Here you find in details version of Clearon
Some Frequently Asked Questions About Clearon
What is Clearon?
Clearon is a prescription drug used for the treatment of chronic iron overload resulting from regular transfusions in people with thalassemia. It works by binding to iron so that it can be removed from the body through the urine.
How should Clearon be taken?
Clearon should be taken exactly as prescribed by your doctor. It is typically taken in tablet form once or twice a day with food. Follow all instructions on your prescription label.
What are the possible side effects of Clearon?
Common side effects of Clearon include nausea, vomiting, diarrhea, headache, dizziness, stomach pain, and rash. In rare cases, more serious side effects may occur, such as liver damage, decreased white blood cell count, and kidney failure.
What should I do if I miss a dose of Clearon?
If you miss a dose of Clearon, take it as soon as you remember. Do not take two doses at the same time. Contact your doctor or pharmacist for advice.
Are there any drug interactions I should be aware of?
Clearon may interact with other medications, such as certain antibiotics, antacids, anticoagulants, and anticonvulsants. Be sure to tell your doctor about all medications you are taking before starting treatment with Clearon.
What should I do if I experience side effects from Clearon?
If you experience side effects from Clearon, contact your doctor or pharmacist right away. They may be able to change your dose or recommend a different medication.
Is there a generic version of Clearon available?
No, there is currently no generic version of Clearon available.
What is the usual dose of Clearon?
The usual dose of Clearon is 10-20 mg/kg body weight, taken once or twice a day with food. The exact dose depends on the individual and their condition, and should be determined by a doctor.
Do I need frequent blood tests when taking Clearon?
Yes, it is important to have periodic blood tests while taking Clearon, as it can cause changes in liver, kidney, and blood cell functions. These tests will help your doctor monitor your condition and make sure the drug is working properly.
Is there an age restriction for taking Clearon?
Yes, Clearon is not recommended for use in children under 6 years of age. Always follow your doctor's instructions and advice when it comes to taking medications.
What should I do if I get pregnant while taking Clearon?
If you become pregnant while taking Clearon, contact your doctor immediately. Clearon has not been studied in pregnant women, and there is not enough information to know if it could cause harm to a developing fetus.
What is the best way to store Clearon?
Clearon tablets should be stored at room temperature away from light, moisture, and heat. Tablets should also be kept out of reach of children and pets.
What should I do if I overdose on Clearon?
If you suspect an overdose, contact a poison control center right away. You can also call your local emergency services, if necessary. It is important to always keep Clearon tablets out of the reach of children and pets.
Does Clearon have any interactions with alcohol?
It is not known if Clearon interacts with alcohol, so it is best to avoid alcohol while taking it. Always talk to your doctor about any risks associated with drinking alcohol while taking medications.
What are the warnings and precautions with Clearon?
Common warnings and precautions with Clearon include close monitoring of liver and kidney function, avoiding activities that could increase the risk of injury or bleeding, and avoiding alcohol and other drugs that can interact with the medication. Contact your doctor for more information.
Is there a drug class for Clearon?
Yes, Clearon belongs to a drug class called iron chelators. Iron chelators work by binding to excess iron in the body, allowing it to be eliminated through the urine.
Are there any other drugs that work in a similar way to Clearon?
Yes, other drugs that work in a similar way to Clearon include Deferiprone and Exjade (deferasirox). These drugs are also iron chelators and are used to treat chronic iron overload.
What is the most important information I should know about Clearon?
The most important information to know about Clearon is that it may cause serious side effects, including liver and kidney damage, decreased white blood cell count, and an increased risk of infection. Contact your doctor right away if you experience any unusual symptoms while taking this medication.
What should I do if I have forgotten to take my Clearon dose?
If you have forgotten to take your Clearon dose, take it as soon as you remember. Do not take two doses at the same time. Contact your doctor or pharmacist for advice.
Are there any certain foods or drinks that should be avoided when taking Clearon?
Specific foods and drinks should be avoided when taking Clearon, including alcohol and grapefruit juice. Iron supplements and dairy products should also be avoided. Always talk to your doctor about specific dietary restrictions while taking Clearon.
What is the overall success rate of treatment with Clearon?
The overall success rate of treatment with Clearon is generally good, as it is effective at reducing and controlling iron overload. However, treatment success will depend on the individual and should always be discussed with a doctor.
Are there any patient assistance programs available for Clearon?
Yes, there are patient assistance programs available for Clearon. These programs provide financial assistance to those who cannot afford the cost of the prescription. Eligibility for the programs varies, so contact your doctor or pharmacist for more information.
Can Clearon be taken with other medications?
Clearon can interact with other medications. Be sure to tell your doctor about all medications you are taking before starting treatment with Clearon. Your doctor can determine the best course of treatment for you.
What kind of laboratory tests should be done while taking Clearon?
While taking Clearon, it is important to have periodic blood tests to monitor liver, kidney, and blood cell functions. Tests can also check for anemia, high levels of iron, and electrolyte balances. It is important to follow your doctor’s instructions for all laboratory tests.
Is it safe to take Clearon long-term?
Clearon is generally safe to take long-term, but it is important to follow your doctor’s instructions about taking the medication. Long-term use may increase your risk of developing serious side effects, so talk to your doctor regularly.
What happens if I stop taking Clearon suddenly?
It is not recommended to stop taking Clearon suddenly, as this may lead to an increase in iron levels. If you wish to stop taking the medication, talk to your doctor first. They will help you decrease your dosage slowly.
Does Clearon have any drug-drug or food-drug interactions?
Clearon may have drug-drug or food-drug interactions with other medications, such as certain antibiotics, antacids, anticoagulants, and anticonvulsants. Be sure to tell your doctor about all medications and supplements you are taking before starting treatment with Clearon.
Is it safe to use Clearon in combination with other medications?
Clearon can be used in combination with other medications, but it is important to tell your doctor about all medications and supplements you are taking before starting treatment. Your doctor can determine if it is safe and effective to take Clearon with other medications.
Should I be careful when taking Clearon with certain types of food?
Yes, certain types of food should be avoided while taking Clearon, including alcohol, dairy products, and iron supplements. Always talk to your doctor about specific dietary restrictions while taking Clearon.
What should I do if I develop a rash while taking Clearon?
If you develop a rash while taking Clearon, contact your doctor right away. They may recommend a different medication or recommend changing your dose. Be sure to talk to your doctor if you experience any side effects while taking Clearon.
What is the best time of day to take Clearon?
Clearon should be taken exactly as prescribed by your doctor. It is typically taken in tablet form once or twice a day with food. Follow all instructions on your prescription label and talk to your doctor if you have any questions.
Is there a difference between the liquid and tablet forms of Clearon?
Yes, there is a difference between the liquid and tablet forms of Clearon. The liquid form must be taken with food, while the tablet form can be taken with or without food. Talk to your doctor to determine which form is right for you.
Can Clearon be taken with food?
Yes, Clearon can be taken with food. It is typically taken in tablet form once or twice a day with food. The liquid form of Clearon must be taken with food. Follow all instructions on your prescription label.
Can the dose of Clearon be changed?
Yes, the dose of Clearon can be changed. The exact dose depends on the individual and their condition, and should be determined by a doctor. Do not change your dose without talking to your doctor first.
Are there any lifestyle changes I should make while taking Clearon?
Yes, it is important to make certain lifestyle changes while taking Clearon. These changes include avoiding activities that could increase the risk of injury or bleeding, avoiding alcohol and other drugs that can interact with the medication, and following a healthy diet and exercise plan. Talk to your doctor for more information.
What should I do if I experience nausea or vomiting when taking Clearon?
If you experience nausea or vomiting when taking Clearon, contact your doctor right away. They may recommend different medications or recommend changing your dose. Be sure to talk to your doctor if you experience any side effects while taking Clearon.
Does Clearon have any interactions with over-the-counter medications or supplements?
Clearon may interact with over-the-counter medications and supplements. Be sure to tell your doctor about any medications or supplements you are taking before starting treatment with Clearon. Your doctor can determine if it is safe and effective to take Clearon with other medications.
What should I do if I experience kidney or liver problems while taking Clearon?
If you experience kidney or liver problems while taking Clearon, contact your doctor right away. You may need to have your dose adjusted or stop taking the medication. Be sure to talk to your doctor if you experience any side effects while taking Clearon.