Canaflo
Canaflo Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Canaflo is a brand name. Its generic name is Canagliflozin.
Introduction
Canaflo is an oral medication used in the treatment of Type 2 Diabetes Mellitus (T2DM). It is a sodium glucose transporter 2 (SGLT2) inhibitor, which blocks the reabsorption of glucose in the kidneys, thus increasing the amount of glucose lost in urine. By doing so, Canaflo can reduce the average blood sugar level of a person with T2DM.Uses For
Canaflo is used to lower blood sugar levels in adults with T2DM. It is usually prescribed when other glucose-lowering medications such as diet and exercise have not been effective in controlling the levels. It can be used alone, or in combination with other medications.Mechanism of Action
Canaflo works by blocking the reabsorption of glucose in the kidneys. Normally, the kidneys reabsorb glucose to help maintain blood sugar levels, but Canaflo blocks this effect, causing the body to excrete more glucose in the urine. This reduces the average blood sugar level in patients with T2DM.How Long Does It Take To Work?
Canaflo starts to take effect as soon as it is taken and the effects can be seen in as little as four weeks. However, optimal results may not be seen for up to 12 weeks.Absorption
Canaflo is rapidly and almost completely absorbed following oral administration. The peak plasma concentration (Cmax) is reached within 2-3 hours.Route of Elimination
Canaflo is primarily eliminated in the urine, with minimal amounts eliminated in the feces.Dosage
The recommended dosage of canagliflozin is 100mg once daily. For those who have difficulty swallowing tablets, the liquid formulation (10mg/mL) can be prescribed instead. The dosage may be lowered to 50mg once daily for those taking certain medications (eg, diuretics) or those with severe kidney impairment.Administration
Canaflo is typically taken once daily in the morning or evening with or without food.Side Effects
Common side effects of Canaflo include: nausea, diarrhea, urinary tract infection, and increased urination. Rare side effects include: dizziness, fatigue, blurred vision, joint pain, urinary urgency, urinary incontinence, and dry mouth.Toxicity
The dose and frequency of Canaflo should not exceed the recommended and should not be combined with other drugs affecting the same mechanism of action. Signs of overdose include nausea, vomiting, abdominal pain, and diarrhoea.Precautions
Canaflo should be used with caution in patients who have a history of kidney or liver disease, as it can worsen their condition. It should also be used with caution in patients who are pregnant or nursing, as it could harm the fetus or child.Interactions
Canaflo may interact with other medications such as angiotensin converting enzyme inhibitors, diuretics, and NSAIDs. It is important to discuss any possible drug interactions with a doctor before taking Canaflo.Disease Interactions
Canaflo should not be used in patients with type 1 diabetes or diabetic ketoacidosis. It should also not be used in patients with severe renal impairment (CrCl <30 ml/min)Drug Interactions
Canaflo may interact with other medications, such as angiotensin converting enzyme inhibitors, diuretics, and nonsteroidal anti-inflammatory drugs. It is important to discuss any potential drug interactions with a doctor before taking canagliflozin.Food Interactions
Canaflo should be taken with a full glass of water and can be taken with or without food. Eating high-fat meals may reduce the absorption of canagliflozin.Pregnancy Use
Canaflo should not be used during pregnancy unless it is absolutely necessary. Women who are pregnant or planning to become pregnant should discuss the risks and benefits of taking this medication with their doctor.Lactation Use
Canaflo should not be used during lactation, as it is excreted in breastmilk. Women who are breastfeeding or planning to breastfeed should discuss the risks and benefits of taking this medication with their doctor.Acute Overdose
In case of acute overdose, it is recommended to seek medical help immediately. Symptoms may include nausea, vomiting, abdominal pain, and diarrhoea.Contraindication
Canaflo should not be used in patients with type 1 diabetes or diabetic ketoacidosis or clients with severe renal impairment (CrCl <30ml/min).Use Direction
Canaflo should be taken exactly as prescribed by a doctor. It should be taken once daily in the morning or evening with or without food. The dose may be changed based on the patient’s response and ongoing blood sugar levels.Storage Condition
Canaflo should be stored at room temperature away from moisture and heat.Volume of Distribution
Canaflo has an estimated volume of distribution of 162L.Half Life
Canaflo has an estimated elimination half-life of 12-17 hours.Clearance
Canaflo has an estimated renal clearance of 30-40 mL/min.Here you find in details version of Canaflo
Some Frequently Asked Questions About Canaflo
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