Buprocaine

Buprocaine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Buprocaine is a brand name. Its generic name is Oxybuprocaine.

Buprocaine Introduction

Buprocaine is a local anesthetic. It is used topically, to produce local anesthesia of the sensory nerves in the area trested. It is primarily used to numb the surface of the skin, mucous membranes and/or conjunctiva prior to procedures such as ocular, otic, and nasal surgery, or injection of local anesthetic agents. It can also be used as an adjunct to local anesthetic procedures.

Uses for Buprocaine

Buprocaine is mainly used for providing a local anesthetic. It is used to numb the treated area, like before surgery, during injections, or any such procedure. It is also used to reduce pain, and prevent eye irritation during eye examinations.

Mechanism of Action

Buprocaine is a local anesthetic and works to reduce the sensation of pain or discomfort in the treated area by temporarily inhibiting the signals of pain travelling along the nerve cells. It works via binding to voltage gated sodium channels at the neuronal membrane, thus blocking the passage of electrical current through the nerve cells. It also decreases the permeability of the membrane of the nerve cells to ions, thus interfering with the flow of ions and preventing the generation of an action potential.

How Long Does it Take to Work?

Buprocaine will begin to take effect within 1-3 minutes of administration. However, the full effects of the anesthetic may take up to 5 minutes.

Absorption

When applied topically, Buprocaine is rapidly absorbed through the skin. It is then metabolized by enzymes in the body and eliminated via the kidneys.

Route of Elimination

Buprocaine is mainly eliminated via the kidneys. It is metabolized by enzymes in the liver and eventually excreted in the urine.

Dosage

The dosage of Buprocaine is vary by the type of procedure, the area of treatment, and the patient's age, weight, and medical history. The usual dose for topical application is 1-2 drops of the 0.4% aqueous solution applied to the affected site four times daily. Special pediatric dosages may be required for children.

Administration

Buprocaine is usually administered topically, directly to the affected area. It is important to follow the instructions provided by a healthcare provider when administering Buprocaine.

Side Effect

Common side effect of Buprocaine include burning, stinging, and redness of the skin. Other side effects may include blurred vision, headache, and dizziness. It is important to contact a healthcare provider immediately if any of these side effects occur.

Toxicity

Buprocaine is generally considered to be safe at normal doses, with no risk of acute toxicity. However, the long-term use of Buprocaine can lead to an increased risk of systemic toxicity. It is therefore important to take the medication as directed and not to exceed the recommended dosage.

Precautions

It is important to use Buprocaine with caution in individuals with a history of allergies or hypersensitivy to local anesthetics. It is also important to use Buprocaine cautiously in individuals with impaired renal or hepatic function, as it may be difficult to eliminate the drug from the body in these conditions. It is also important to avoid using Buprocaine in the area of the eyelids, as it may cause irritation or burning.

Interactions

Buprocaine should be used cautiously with medications that are known to cause increased sensitivity to local anesthetics, such as beta-blockers, lidocaine, and epinephrine. It should also be used cautiously in individuals taking medications that affect liver or kidney function, as it may be difficult to eliminate the drug from the body in these conditions.

Disease Interactions

Buprocaine should be used with caution in individuals with diabetes or any other condition that may affect the nervous system. It should also be used with caution in individuals with cardiovascular and/or respiratory conditions.

Drug Interactions

Buprocaine should be used cautiously with medications that are known to cause increased sensitivity to local anesthetics, such as beta-blockers, lidocaine, and epinephrine. It should also be used cautiously in individuals taking medications that affect liver or kidney function, as it may be difficult to eliminate the drug from the body in these conditions.

Food Interactions

There are no known food interactions with Buprocaine.

Pregnancy Use

Buprocaine should not be used during pregnancy unless absolutely necessary. It is important to consult a doctor before taking this medication during pregnancy.

Lactation Use

Buprocaine is not known to excrete in breast milk. Therefore, it is generally considered safe to use during breastfeeding.

Acute Overdose

The symptoms of an acute overdose of Buprocaine include excessive sleepiness, confusion, difficulty in breathing, and rapid heartbeat. If these symptoms occur, immediate medical attention is necessary.

Contraindications

Buprocaine should not be used in individuals who are allergic or hypersensitive to local anesthetics. It is also not recommended in individuals with respiratory depression, heart block, or uncontrolled hypertension. Additionally, it should not be used in individuals with severe hepatic or renal impairment.

Use Direction

Buprocaine must be used exactly as directed by a healthcare provider. It should only be applied topically, directly to the affected area, and should not be ingested or injected. In addition, the dosage should not be exceeded.

Storage Condition

Buprocaine must be stored in a dry, cool place and out of the reach of children. The drug should never be stored in an area, such as a bathroom, where it may come into contact with direct sunlight or heat.

Volume of Distribution

The volume of distribution of Buprocaine has not yet been determined.

Half Life

The half-life of Buprocaine is approximately 4.4 hours.

Clearance

The clearance of Buprocaine is approximately 9.5 mL/min/kg.

Here you find in details version of Buprocaine

Some Frequently Asked Questions About Buprocaine

What is Buprocaine?

Buprocaine (trade name Benoxinate) is a local anesthetic used to numb the surface of the eye for a variety of eye operations and procedures.

How is Buprocaine administered?

Normally administered as a few drops applied directly to the eye.

What is the onset of action of Buprocaine?

Buprocaine usually reaches maximum effect after about five minutes.

What is the mechanism of action of Buprocaine?

The anesthetic works by blocking sodium channels, which stops the transmission of nerve impulses to the brain.

What is the duration of effect of Buprocaine?

The effect of Buprocaine usually lasts around 30 minutes.

Are there any patient warnings for Buprocaine?

Patients may experience blurred vision for a few moments after the Buprocaine is administered.

Are there any drug interactions with Buprocaine?

Buprocaine should not be used in conjunction with other anesthetics, as this can cause a dangerous decrease in blood pressure.

What are the side effects of Buprocaine?

Side effects associated with Buprocaine can include stinging, burning, light sensitivity, and blurred vision.

Are there any contraindications to using Buprocaine?

Buprocaine is not recommended if the patient is taking monoamine oxidase inhibitors or has had a recent corneal transplant.

What are the pregnancy and breastfeeding risks associated with Buprocaine?

Buprocaine should not generally be used by pregnant women or those breastfeeding, as it is not known if the drug passes through breast milk.

What is the correct dose of Buprocaine?

The correct dose of Buprocaine will be determined by your doctor or eye specialist.

Can Buprocaine be used with contact lenses in?

Buprocaine should not be used with contact lenses in, as the lenses can prevent the anesthetic from getting to the eye's surface.

What should I do if I get Buprocaine in my mouth?

If Buprocaine is accidentally ingested, rinse out your mouth with water and contact your doctor immediately.

Are there any alternatives to Buprocaine?

Other topical anesthetics that may be used instead of Buprocaine include lidocaine, proparacaine, and tetracaine.

Should Buprocaine be stored in the refrigerator?

No, Buprocaine should be stored at room temperature away from heat and light.

Is Buprocaine a prescription medication?

Yes, in most countries Buprocaine is only available with a prescription from a doctor or eye specialist.

Is Buprocaine a generic medication?

No, Buprocaine is a brand name for Benoxinate, a local anesthetic.

What does Buprocaine do?

Buprocaine is an anesthetic used to numbing the surface of the eye for a variety of eye operations and procedures.

Can I use Buprocaine without a doctor's prescription?

No, Buprocaine is only available with a prescription from a doctor or eye specialist.

How long does Buprocaine take to work?

Buprocaine usually reaches maximum effect after about five minutes.

Is Buprocaine safe to use with other medications?

Buprocaine should not be used with other anesthetics, as this can cause a dangerous decrease in blood pressure.

How long does the effect of Buprocaine last for?

The effect of Buprocaine usually lasts around 30 minutes.

What are the possible side effects of Buprocaine?

Side effects associated with Buprocaine can include stinging, burning, light sensitivity, and blurred vision.

Are there any contraindications for using Buprocaine?

Buprocaine is not recommended if the patient is taking monoamine oxidase inhibitors or has had a recent corneal transplant.

Can Buprocaine be used in pregnant or breastfeeding women?

Buprocaine should not generally be used by pregnant women or those breastfeeding, as it is not known if the drug passes through breast milk.

What happens if Buprocaine gets into my mouth?

If Buprocaine is accidentally ingested, rinse out your mouth with water and contact your doctor immediately.

How should Buprocaine be stored?

Buprocaine should be stored at room temperature away from heat and light.

Can Buprocaine be used with contact lenses in?

Buprocaine should not be used with contact lenses in, as the lenses can prevent the anesthetic from getting to the eye's surface.

What type of medications should not be used with Buprocaine?

Buprocaine should not be used with other anesthetics, as this can cause a dangerous decrease in blood pressure.

What will happen if Buprocaine is used more than the recommended dose?

Using more than the recommended dose of Buprocaine can cause a dangerous decrease in blood pressure.

Can Buprocaine be used for corneal transplants?

Buprocaine is not recommended if the patient has had a recent corneal transplant.

Are there any other topical anesthetics similar to Buprocaine?

Other topical anesthetics that may be used instead of Buprocaine include lidocaine, proparacaine, and tetracaine.

How should Buprocaine be disposed off?

Buprocaine should be properly disposed of as per local regulations and instructions.

Can Buprocaine be used on children?

Buprocaine can be used on children, but it should only be done under the supervision of a doctor or pediatric eye specialist.

At what age is Buprocaine appropriate to be used?

Buprocaine can be used from birth onwards, but it should only be done under the supervision of a doctor or pediatric eye specialist.

Can Buprocaine be used on animals?

Buprocaine can be used on animals, but it should always be done under the supervision of a vet.

What is the generic name of Buprocaine?

The generic name of Buprocaine is Benoxinate.

Are there any medications that should not be taken with Buprocaine?

Buprocaine should not be used with other anesthetics, as this can cause a dangerous decrease in blood pressure.

Are there any adverse reactions to Buprocaine?

Possible side effects associated with Buprocaine can include stinging, burning, light sensitivity, and blurred vision.

Can Buprocaine be used in combination with other medications?

Buprocaine should not be used with other anesthetics, as this can cause a dangerous decrease in blood pressure.

What type of eye conditions can Buprocaine be used for?

Buprocaine is used to numb the surface of the eye for a variety of eye operations and procedures.

What are the precautions when using Buprocaine?

Patients should avoid touching or rubbing the eye after using Buprocaine and should take care not to blink excessively.

What should I do if I experience an adverse reaction to Buprocaine?

If you experience any adverse reaction after using Buprocaine, contact your doctor or eye specialist immediately.

Which parts of the eye are affected by Buprocaine?

Buprocaine numbs the surface of the eye, mainly affecting the cornea and conjunctiva.

What type of doctor prescribes Buprocaine?

In most countries Buprocaine is only available with a prescription from a doctor or eye specialist.