Axinix
Axinix Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Axinix is a brand name. Its generic name is Axitinib.
Axinix Introduction
Axinix is a drug used to treat advanced kidney cancer, thyroid cancer, and other advanced solid tumors. It is a small molecule tyrosine kinase inhibitor (TKI), inhibiting several members of the vascular endothelial growth factor (VEGF) family. Axinix is manufactured by drug company Pfizer.Uses for Axinix
Axinix is used for the treatment of advanced renal cell carcinoma and advanced thyroid cancer after failure of other treatments. It is also used for the treatment of advanced medullary thyroid cancer and recurrent/metastatic papillary thyroid cancer.Mechanism of Action
Axinix works as a tyrosine kinase inhibitor, blocking the action of the VEGF. This interrupts the growth of new blood vessels which tumors require to grow.How Long Does it Take to Work?
It can take 2-4 weeks after starting treatment with axitinib before its effects can be seen. However, as everyone is different it may take longer for some people.Absorption
Axinix is quickly and almost completely absorbed, with the maximum plasma concentration usually occurring within 3 hours of administration.Route of Elimination
Approximately 70% of axitinib is eliminated unchanged via faeces and 15% is recovered in the urine.Dosage
Axinix is available in 5mg, 10mg, 15mg, and 20mg tablet strengths. The usual starting dose is 5mg twice daily, taken on an empty stomach. After two weeks, if tolerated well, the dose may be increased to 10mg twice daily.Administration
Axinix tablets are taken by mouth with a full glass of water, on an empty stomach at least one hour before or two hours after meals.Side Effect
Common side effects reported with axitinib therapy include: hypertension, fatigue, diarrhea, decreased appetite, weight loss, nausea, swelling of the hands and feet, and pain in the palms of the hands and soles of the feet.Toxicity
The most common side effect of axitinib toxicity is high blood pressure. In addition, axitinib may cause skin rash, decreased white blood cell count and elevated liver enzymes.Precautions
Patients should be monitored for hypertension and other side effects during axitinib therapy. Patients should not take any other drugs that may increase their risk of toxicity while taking axitinib.Interactions
Axinix can interact with certain drugs like mitotane, herbal supplements, and antifungals which may increase the risk of toxicity. Patients should discuss all medications, over-the-counter products, and supplements with their doctor before taking axitinib.Disease Interactions
Axinix may cause serious or life-threatening problems in patients with a history of heart disease, stroke or bleeding problems, or diabetes. Patients should discuss any underlying medical conditions with their doctor before treatment with axitinib.Drug Interactions
Axinix may interact with certain drugs, which can increase the risk of side effects or make the drugs less effective. It is important to tell your doctor about all other medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements.Food Interactions
Axinix may interact with certain foods, including grapefruit and grapefruit juice, which can increase the risk of side effects. Patients should avoid these foods while taking axitinib.Pregnancy Use
Axinix is classified as a Pregnancy Category D medication, which means it can cause harm to the fetus if taken during pregnancy. Pregnant women should not take this medication unless the potential benefits outweigh the potential risks.Lactation Use
It is not known if axitinib is secreted in human milk. Breastfeeding women should not take axitinib unless the potential benefits outweigh the potential risks.Acute Overdose
If an overdose of axitinib is suspected, contact a healthcare provider or poison control center immediately. Symptoms of an overdose may include nausea, vomiting, diarrhea, low blood pressure, and difficulty breathing.Contraindication
Axinix is contraindicated in patients with severe hypersensitivity to the drug or any of its components.Use Direction
Axinix tablets should be taken exactly as prescribed by the doctor. The tablets should be taken by mouth, on an empty stomach, at least one hour before or two hours after a meal. Do not take more or less of the drug than prescribed.Storage Condition
Axinix tablets should be stored at room temperature, away from moisture and heat.Volume of Distribution
The volume of distribution of axitinib is approximately 14.2 L/kg.Half Life
The average elimination half-life of axitinib is approximately 21 hours.Clearance
The average clearance of axitinib is approximately 10 mL/min/kg.Here you find in details version of Axinix
Some Frequently Asked Questions About Axinix
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