Anthisan
Anthisan Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Anthisan is a brand name. Its generic name is Mepyramine.
Anthisan
Anthisan is an antihistamine and anti-inflammatory drug used to treat allergies, itching, rhinitis, and certain skin disorders. It is used as an anti-allergic agent to reduce itching, sneezing, and other allergy symptoms. Anthisan is also used to reduce discomfort and redness from inflammation, sunburns, and other skin conditions.
Uses For
Anthisan is used to relieve the symptoms of seasonal allergy (hay fever), perennial allergic rhinitis (e.g. dust and pet allergy), and skin allergies (eczema, contact dermatitis, hives). It is also used to relieve pruritus (itching) and inflammation related to insect bites, sunburns, and other skin conditions.
Mechanism of Action
Anthisan works by blocking histamine H1 receptors on cells, which prevents histamine from binding to them and causes anti-allergic and anti-inflammatory effects. The drug also has anticholinergic effects, which work by blocking the neurotransmitter acetylcholine from binding to its receptors. This action is primarily responsible for meapyramine's sedative effects.
How Long Does It Take To Work?
Anthisan typically begins to work within 30 minutes of ingestion. Some users may experience relief within 15 minutes while others may take up to 2 hours to feel the medication’s full effects.
Absorption
Anthisan is rapidly and completely absorbed from the gastrointestinal tract. Its peak plasma concentrations are usually reached in 1-2 hours after ingestion.
Route of Elimination
Anthisan is metabolized in the liver and is primarily excreted as metabolites in the urine. Some of the drug is also eliminated in the bile and feces.
Dosage
The recommended dosage for adult use of mepyramine is 25-50 mg orally twice a day. The maximum daily dose should not exceed 100 mg. For pediatric use, the recommended dosage is 2-6 mg per kg of body weight daily in divided doses.
Administration
Anthisan can be taken orally with or without food. If stomach upset occurs, it can be taken with food. Avoid taking while lying down, as it can cause dizziness or fainting.
Side Effects
The most common side effects associated with mepyramine are drowsiness, dizziness, blurred vision, dry mouth, and nausea. Other possible side effects include constipation, difficulty urinating, and insomnia.
Toxicity
The therapeutic dose of mepyramine is safe and well tolerated in adults with no evidence of toxicity, however, high doses of mepyramine can cause symptoms of overdose which can include seizures, hallucinations, and coma. Serious toxicity is rare.
Precautions
Anthisan should not be used by people who have had recent surgery or who are taking medications for depression, as it can increase the risk of side effects. People with kidney or liver disease should be monitored closely when taking mepyramine as the drug can accumulate in the blood. Women who are pregnant or breastfeeding should consult a physician before taking mepyramine.
Interaction
Anthisan may interact with other medications, including anticholinergics, monoamine oxidase inhibitors (MAOIs), anti-arrhythmic drugs, and barbiturates. Patients should inform their doctor of any medications they are taking before taking mepyramine to avoid potential interactions.
Disease Interaction
Anthisan may worsen the symptoms of asthma, COPD, and other respiratory conditions. It is also not recommended for use by people with an active fungal infection. Patients should consult their doctor before taking mepyramine if they have any of these conditions.
Drug Interaction
Anthisan may interact with other medications, particularly other antihistamines, anticholinergics, MAOIs, anti-arrhythmic drugs, and barbiturates. Patients should inform their doctor of any medications they are taking before taking mepyramine to avoid potential interactions.
Food Interactions
Anthisan can interact with certain foods, particularly dairy products. It is best taken with a full glass of water and with food to reduce the risk of stomach upset.
Pregnancy Use
Anthisan should not be used during pregnancy as it may increase the risk of birth defects and other serious complications. Women who are pregnant or breastfeeding should consult a physician before taking mepyramine.
Lactation Use
Anthisan is excreted in breast milk, so nursing mothers should not take mepyramine. Women who are breastfeeding should consult a physician before taking mepyramine.
Acute Overdose
An acute overdose of mepyramine can cause extreme drowsiness, seizures, hallucinations, coma, and even death. If an overdose is suspected, seek medical help immediately.
Contraindication
Anthisan should not be used by people with an active fungal infection or a history of hypersensitivity to the drug. It should also not be used by people taking monoamine oxidase inhibitors (MAOIs), as this increases the risk of side effects.
Use Direction
Anthisan should be taken as directed by the prescribing physician. It can be taken with or without food, but should be taken with a full glass of water to reduce the risk of stomach upset. Unless otherwise directed, it should be taken twice daily, once in the morning and once in the evening.
Storage Condition
Anthisan should be stored at room temperature in a dry place, protected from light and moisture. It should be kept out of the reach of children and pets.
Volume of Distribution
The volume of distribution of mepyramine is approximately 0.2 L/kg.
Half Life
The half life of mepyramine is approximately 5 hours.
Clearance
The clearance of mepyramine is approximately 0.2 mL/min/kg
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