Antevir Tablet

Brand Name: Antevir
Generic: Entecavir
Weight: 0.5 mg
Type: Tablet
Therapeutic Class: Hepatic viral infections (Hepatitis B)
Manufacturer: Albion Laboratories Limited
Price: 63.00
Last Updated: 2020-11-21 18:15:00

Antevir Tablet Uses

Antevir Tablet contains Entecavir. Antevir uses:

Antevir Tablet is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease, evidence of viral replication and histologically documented active liver inflammation or fibrosis. It is also effective in decompensated cirrhosis.

Antevir Tablet Doses

Antevir Tablet contains Entecavir 0.5 mg. Antevir doses:

Administration of Antevir Tablet with food decreases absorption and so it should be taken in an empty stomach (at least 2 hours before or 2 hours after meal). 

Adult over 16 years, not previously treated with nucleoside analogues: 0.5 mg once daily.

Adult over 16 years with lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily.


Side Effects

The most common side effects are headache, fatigue, dizziness and nausea.


Antevir Tablet is a guanosine nucleoside analogue with potent and selective activity against HBV polymerase. For pharmacological action it is phosphorylated to the active triphosphate (TP) form. Antevir Tablet triphosphate functionally inhibits all 3 activities of the viral polymerase-

  • Priming of the HBV polymerase,
  • Reverse transcription of the negative strand from the pregenomic messenger RNA
  • Synthesis of the positive strand HBV DNA.
Antevir Precaution

Monitor liver function tests every 3 months, and viral and serological markers for hepatitis B every 3-6 months. Discontinue if deterioration in liver function, hepatic steatosis, progressive hepatomegaly or unexplained lactic acidosis. Recurrent hepatitis may occur on discontinuation.


Since Antevir Tablet is predominantly eliminated by the kidney, coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either drug.

Pregnancy Lactation use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Antevir Tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not known whether Antevir Tablet is excreted in human milk. Mothers should be instructed not to breast-feed if they are taking Antevir Tablet.


Antevir Tablet is contraindicated in patients with previously demonstrated hypersensitivity to Antevir Tablet or any component of the product.

Special Warning

Use in pediatric patient: Safety and effectiveness of Antevir Tablet in pediatric patients below the age of 16 years have not been established.

Use in geriatric patient: Antevir Tablet is significantly excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Dose adjustment in renal impairment: Dose adjustment is recommended for patients with CrCl <50 ml/min including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) as shown in the following table.

CrCl ≥50 ml/min: 0.5 mg every 24 hours

CrCl 30 to <50 ml/min: 0.5 mg every 48 hours

CrCl 10 to <30 ml/min: 0.5 mg every 72 hours

CrCl <10 ml/min or  Hemodialysis or CAPD: 0.5 mg every 7 days

Acute Overdose

There is no experience of Antevir Tablet overdosage reported in patients. Healthy subjects who received up to 20 mg daily for up to 14 days and single doses up to 40 mg had no unexpected adverse events. If overdosage occurs, the patient must be monitored for evidence of toxicity and standard supportive treatment as necessary.

Interaction with other Medicine


Storage Condition

Store at temperatures not above 30°C.

Antevir Tablet price in Bangladesh 63.00