Acliz

Acliz Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Acliz is a brand name. Its generic name is Meclizine.

Acliz

Acliz is an antihistamine with anticholinergic (drying) and sedative side effects. It is commonly used to treat motion sickness and as a central nervous system depressant. It is used to treat nausea, vomiting, and dizziness associated with motion sickness, and is also used off-label to treat vertigo.

Uses for

Acliz is used to treat symptoms of motion sickness such as dizziness, nausea, and vomiting. It may also be used to treat vertigo or other balance disorders. It is also sometimes used to treat symptoms of Meniere's disease.

Mechanism of Action

Acliz's mechanism of action is thought to involve its action on H1-receptors in the CNS, which leads to sedation as well as its antimuscarinic effects, which cause an inhibition of the vomiting center in the brain. It also produces a mild antiemetic effect by blocking the afferent vagal and mesolimbic pathways in the brain.

How Long Does it Take to Work?

The effects of Acliz usually begin within 15-30 minutes after taking the medication and last for 4-6 hours.

Absorption

Acliz is absorbed rapidly after oral administration, with peak plasma concentrations reached within one hour of ingestion. It has high bioavailability and is more than 95% bound to plasma proteins.

Route of Elimination

Acliz is metabolized in the liver by the cytochrome P450 enzyme system, and is primarily excreted in the urine as metabolites and in small amounts in the feces.

Dosage

The recommended adult dose of Acliz for motion sickness is 25-50 mg orally one hour before activities, and up to 25 mg orally every four to six hours as needed. The dose may be taken two to three hours before travel and repeated every eight to twelve hours as needed while traveling. The maximum adult dose for motion sickness is 150 mg/day.

Administration

Acliz is usually taken orally with water. It can be taken with or without food.

Side Effect

Common side effects of Acliz may include dry mouth, headache, drowsiness, dizziness, blurred vision, nausea, vomiting, constipation, and nervousness.

Toxicity

Acliz is generally well tolerated in recommended doses; however, an overdose of Acliz may cause significant toxicity. Symptoms of an overdose may include confusion, drowsiness, shakiness, headache, nausea, vomiting, rapid heartbeat, watery eyes, or dry mouth.

Precaution

Acliz should be avoided in patients with glaucoma, obstructive uropathy, or in patients with severe hepatic or renal impairment. It should also not be used in patients with a known hypersensitivity to Acliz or its ingredients. It should be used cautiously in patients with a history of stroke or coronary artery disease, and in elderly patients.

Interaction

Acliz may interact with other antihistamines, tricyclic antidepressants, anticholinergics, central nervous system (CNS) depressants, certain antibiotics, phenothiazines, or drugs that affect liver enzymes.

Disease Interaction

Acliz may make certain underlying medical conditions worse including kidney or liver disease, asthma, enlarged prostate, narrow-angle glaucoma, or seizure disorders.

Drug Interaction

Certain drugs may interact with Acliz, including barbiturates, benzodiazepines, antipsychotics, narcotics, beta-blockers, some antibiotics, and antifungals.

Food Interactions

Acliz may interact with certain foods, including foods high in caffeine, alcohol, and grapefruit products.

Pregnancy Use

Acliz should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Acliz passes into breast milk, so caution should be taken when using this medication during breastfeeding.

Lactation Use

It is unknown if Acliz passes into breast milk, so caution should be taken when using this medication during breastfeeding.

Acute Overdose

Symptoms of an overdose may include confusion, drowsiness, shakiness, headache, nausea, vomiting, rapid heartbeat, watery eyes, or dry mouth. If an overdose is suspected, seek medical help immediately.

Contraindication

Acliz should not be used in patients with a known hypersensitivity to Acliz or its ingredients. It should also be avoided in patients with narrow-angle glaucoma, obstructive uropathy, severe hepatic or renal impairment, or seizures.

Usage Direction

Use Acliz as directed by your doctor. Follow all directions on your medication label. Do not take this medication in larger or smaller amounts or for longer than recommended.

Storage Condition

Store Acliz at room temperature, away from light and moisture. Do not store in the bathroom.

Volume of Distribution

The estimated volume of distribution of Acliz is 2.3 L/kg.

Half Life

The elimination half-life of Acliz in adults is 12.4 hours.

Clearance

The average clearance of Acliz is approximately 3 mL/min/kg.

Here you find in details version of Acliz

Some Frequently Asked Questions About Acliz

What is Acliz?

Acliz is an antihistamine used to treat motion sickness and dizziness caused by balance problems.

What is Acliz used for?

Acliz is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused by disease that affects your inner ear.

Is Acliz used to treat vertigo?

Yes, Acliz is used to treat the symptoms of vertigo caused by a variety of underlying causes.

How long does it take for Acliz to work?

Acliz typically starts to work within 30 minutes after taking it orally. Maximum effects may take up to an hour.

What are the most common side effects of Acliz?

The most common side effects of Acliz include dry mouth, drowsiness, dizziness, fatigue, and abdominal pain.

Can I take Acliz while pregnant?

As with any medication, it is best to consult with your doctor before taking Acliz while pregnant. Acliz is classified as a pregnancy category B drug which means that it is not expected to be harmful to an unborn baby.

What are the side effects of taking too much Acliz?

Taking too much Acliz may cause symptoms such as drowsiness, confusion, nervousness, agitation, blurred vision, nausea, and vomiting.

Can I take Acliz with other medications?

Yes, it is possible to take Acliz with other medications. However, it is always important to inform your doctor of all medications that you are taking before starting any new ones.

What is the recommended dosage of Acliz?

The recommended dosage of Acliz is 25-50mg orally every 6-12 hours, depending on the severity of symptoms.

How should Acliz be taken?

Acliz should be taken with a full glass of water and may be taken with or without food.

What should I do if I miss a dose of Acliz?

If you miss a dose of Acliz, take it as soon as you remember and continue with your normal schedule. Do not take a double dose to make up for a missed one.

Can I drink alcohol while taking Acliz?

It is not recommended to drink alcohol while taking Acliz, as it can increase the risk of side effects such as drowsiness, confusion, and low blood pressure.

How long does it take for Acliz to leave your system?

Acliz typically leaves the system in 72 hours, but this can vary depending on factors such as metabolism and dosage taken.

Is Acliz safe for children?

Acliz is not recommended for use in children under the age of 12, as the safety and efficacy have not been established.

Is Acliz addictive?

Acliz is not considered to be addictive or habit-forming, but it can be unsafe in high doses or with long-term use.

Are there any interactions with Acliz and other drugs?

Yes, there are several potential interactions with Acliz and other drugs. Always inform your healthcare provider of any medications you are taking, including over-the-counter medications, vitamins, and dietary supplements.

Is Acliz available over-the-counter?

Yes, Acliz is available over-the-counter in 25mg doses.

Can Acliz be used for nausea and vomiting?

Yes, Acliz can be used to treat nausea and vomiting associated with motion sickness and vertigo.

Is it safe to take Acliz if I have allergies to other medications?

Yes, it is usually safe to take Acliz if you have allergies to other medications. Always speak to your healthcare provider if you have any allergies or have had any prior reactions to medications.

Can I drive while taking Acliz?

It is not recommended to drive while taking Acliz due to the potential for drowsiness and impaired alertness.

Can Acliz cause constipation?

Yes, constipation is a potential side effect of Acliz. Talk to a doctor if you experience constipation while taking this medication.

Can I take Acliz if I have diabetes?

Yes, you may take Acliz if you have diabetes. Talk to a doctor if you have any questions or concerns.

What should I do if I experience a severe allergic reaction to Acliz?

If you experience a severe allergic reaction to Acliz, stop taking the medication immediately and contact your healthcare provider or seek emergency medical help.

Can I take ibuprofen while taking Acliz?

Yes, it is usually safe to take ibuprofen while taking Acliz. However, it is important to speak to a healthcare provider before taking any new medications while taking Acliz.

Is it safe to take Acliz during breastfeeding?

There is limited data on the safety of Acliz during breastfeeding. It is best to speak to a doctor if you are considering taking this medication while breastfeeding.

Is it safe to take Acliz long-term?

Acliz is generally considered safe to take long-term. However, it is important to speak to a doctor if you are considering taking this medication long-term.

Can Acliz cause weight gain?

There is limited data on whether Acliz can cause weight gain. If you experience any changes in weight while taking Acliz, it is important to speak to a doctor.

Is Acliz a sedative?

Acliz is not a sedative but is known to cause drowsiness as a side effect, which is why it is important to speak to a doctor before driving or operating heavy machinery while taking this medication.

How long should I take Acliz before going to bed?

You should take Acliz at least one hour before bedtime in order to reduce the potential for drowsiness. It is important to speak to your doctor about the best timing for your specific needs.

Can I take Acliz and Dramamine together?

You should not take Acliz and Dramamine together as both medications are used to treat motion sickness.

Can Acliz cause anxiety?

Anxiety is a potential side effect of Acliz. It is important to speak to your doctor if you experience anxiety while taking this medication.

Can I take over-the-counter medications while taking Acliz?

Yes, you may take some over-the-counter (OTC) medications such as pain relievers, decongestants, and antihistamines while taking Acliz. However, it is important to speak to your doctor or pharmacist before taking any OTC medications while taking Acliz.

Can I take Acliz if I am taking blood pressure medication?

Yes, you may take Acliz if you are taking blood pressure medication. However, it is important to speak to your doctor about any potential interactions between the two.

Does Acliz interact with other medications?

Yes, Acliz can interact with other medications such as anticholinergics, alcohol, certain antibiotics, antidepressants, and sedatives.

Can I take Acliz if I have kidney disease?

Yes, you may take Acliz if you have kidney disease. However, it is important to speak to your doctor as they may need to adjust the dosage.

What is the best way to store Acliz?

Acliz should be stored at room temperature away from direct light and heat. Make sure to keep the medication out of reach of children and pets.

Is it safe to take Acliz if I have high blood pressure?

Yes, it is usually safe to take Acliz if you have high blood pressure. However, it is important to speak to a doctor about any precautions that may need to be taken.

Can Acliz cause dry mouth?

Yes, dry mouth is a potential side effect of Acliz. It is important to speak to a doctor if you experience dry mouth while taking this medication.

Does Acliz cause drowsiness?

Yes, drowsiness is a common side effect of Acliz. It is important to speak to your doctor if you experience drowsiness while taking this medication.

Can Acliz cause constipation?

Yes, constipation is a potential side effect of Acliz. Talk to your doctor if you experience constipation while taking this medication.