Winbp Am contains Amlodipine. Winbp Am uses:

Patients with mild to moderate hypertension (alone or in combination with other antihypertensives).

The treatment of chronic stable and vasospastic angina.

Raynaud\'s disease.

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Brand Name: Winbp Am
Generic: Amlodipine
Weight: 5.0 Mg
Type: Tablet
Therapeutic Class: Calcium-channel blockers
Manufacturer: ABBOTT HEALTHCARE PVT LTD
Price: 336.92
Last Updated: 2020-11-21 18:15:00

Doses

Winbp Am contains Amlodipine 5.0 Mg. Winbp Am doses

For treatment of both hypertension and angina pectoris, the usual initial dose is 5 mg once daily. If the desired therapeutic effect cannot be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Winbp Am 10 mg once daily provides symptomatic improvement in patients with Raynaud's disease.

Use in children: Use of Winbp Am in children (under 12 years of age) is not recommended.

 

Side Effects

Winbp Am is generally well tolerated. The most commonly observed side effects are headache, peripheral oedema, palpitations, flushing, dizziness, nausea, abdominal pain.

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Introduction

Winbp Am is a Dihydropyridine Calcium antagonist that inhibits the transmembrane influx of Calcium ions into cardiac and vascular smooth muscle. It has greater affinity towards vascular smooth muscle than on cardiac muscle. Winbp Am is peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and thereby reduces blood pressure. Winbp Am reduces tone, decreases coronary vasoreactivity and lowers cardiac oxygen demand by reducing after load.

Precaution

Hypotension: Since the vasodilUse in renal failure

Although Winbp Am is excreted primarily via kidney, mild renal impairment does not appear to have an effect on the plasma concentrations. Severe renal impairment may however require a dosage reduction. Winbp Am is not dialyzable.

 

Use in patients with impaired hepatic function

Winbp Am half-life is prolonged in patient with impaired hepatic function. Winbp Am should therefore be administered at lower (5mg) initial dose in these patients.

Use in heart failure

An increased number of pulmonary oedema has been reported.atation induced by Winbp Am is gradual in onset, acute hypotension has rarely been reported after oral administration of Winbp Am. Nonetheless, caution should be exercised when administering the drug with any other peripheral vasodilator particularly in patients with severe aortic stenosis.

Cardiac failure: Patients with heart failure should be treated with caution. Calcium channel blockers, including Winbp Am, should be usedwith caution in patients with congestive heart failure, as they may increase the risk of future cardiovascular events and mortality.

Beta blocker withdrawal: Winbp Am gives no protection against the danger of abrupt beta blocker withdrawal; any such withdrawal should be gradualreduction of the dose of beta blocker.

Hepatic failure: The half-life of amlodipine is prolonged and AUC values are higher in patients with impaired liver function. Winbp Am should therefore be initiated at the lower end of the dosing range and caution should be used, both on initial treatment and when increasing the dose. Slow dose titration and careful monitoring may be required in patients with severe hepatic impairment.

Interaction

Use of Winbp Am together with thiazide diuretics or angiotensin-converting-enzyme inhibitors in the treatment of hypertension is additive. There are no hazardous interaction of Winbp Am with Digoxin, Cimetidine, Warfarin and food.

Pregnancy Lactation use

Pregnancy: Safety in pregnancy has not been established.

Lactation: It is not known whether Winbp Am is excreted in breast milk. It is advised to stop breastfeeding during treatment with Winbp Am.

Contraindication

Winbp Am is contraindicated in patients with-

  • Hypersensitivity to amlodipine, dihydropyridine derivatives or any of the excipients
  • Shock (including cardiogenic shock)
  • Obstruction of the outflow-tract of the left ventricle (e.g. high grade aortic stenosis)
  • Unstable angina
  • Hemodynamically unstable heart failure after acute myocardial infarction (during the first 28 days)
  • Severe hypotension
Special Warning

Children with hypertension from 6 years to 17 years of age: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in pediatric patients.

Children under 6 years old:  The effect of amlodipine on blood pressure in patients less than 6 years of age is not known.

Elderly: Winbp Am used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.

Renal impairment: Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Winbp Am is not dialysable.

Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautions and should start at the lower end of the dosing range. The pharmacokinetics of Winbp Am have not been studied in severe hepatic impairment. Winbp Am should be initiated at the lowest dose (2.5 mg once daily) and titrated slowly in patients with severe hepatic impairment.

Acute Overdose

There is no well documented experience with Winbp Am overdosage. In case of clinically significant hypotension due to Winbp Am over dosage, calls for active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities and attention to circulating fluid volume and urine output. Since Winbp Am is highly protein-bound, dialysis is unlikely to be of benefit.

Interaction with other Medicine

 

Storage Condition

Keep out of the reach of children. Store below 30° C. Keep in the original package in a cool & dry place in order to protect from light and moisture.

Winbp Am Tablet price in India 336.92

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