Voxpert contains Voriconazole. Voxpert uses:

Aspergillosis, Candida albicans, Candidaemia, Candidemia, Candidiasis, Coccidioidomycosis, Deep tissue candida infections, Disseminated candidiasis, Fungal keratitis, Histoplasmosis, Invasive aspergillosis, Scedosporiosis and fusariosis

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Brand Name: Voxpert
Generic: Voriconazole
Weight: 200.0 Mg
Type: Tablet
Therapeutic Class: Other Antifungal preparations
Manufacturer: KOYE PHARMACEUTICALS PVT LTD
Price: 3060
Last Updated: 2020-11-22 18:15:00

Doses

Voxpert contains Voriconazole 200.0 Mg. Voxpert doses

Adult

  • ≥40 kg: 400 mg (10 mL) 12 hrly for the 1st 24 hr, followed by 200 mg (5 mL) 12 hrly, may increase to 300 mg 12 hrly or reduce by decrements of 50 mg if necessary.
  • <40 kg: 200 mg (5 mL) 12 hrly for the 1st 24 hr, followed by 100 mg (2.5 mL) 12 hrly, may increase to 150 mg 12 hrly or reduce by decrements of 50 mg if necessary. For oesophageal candidiasis: Treatment should be given for at least 14 days and continued for 7 days after symptoms resolved.

Child

: 2-14 yr <50 kg: 9 mg/kg (Max: 350 mg) 12 hrly.

Should be taken on an empty stomach. Take at least 1 hr before or after meals.

Add 46 ml of water to the bottle containing 45 g of voriconazole to provide a susp containing 40 mg/mL. Shake vigorously for about 1 min.

Side Effects

Anaphylactoid reactions (e.g. flushing, fever, sweating, tachycardia, chest tightness, dyspnoea, faintness, nausea, pruritus, rash). Photosensitivity reactions, skeletal effects e.g. fluorosis, periortitis (in long-term therapy), visual disturbances (e.g. abnormal or blurred vision, color vision change, photophobia), GI effects (nausea, vomiting, diarrhoea, abdominal pain), fever, rash, chills, headache, abnormal LFT result, tachycardia, hallucinations.

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Introduction

Voxpert is a triazole antifungal agent which inhibits cytochrome P450-dependent enzymes thereby inhibiting ergosterol synthesis in fungal cell membranes. It has a broad spectrum of activity against all Candida species (including strains resistant to fluconazole), Aspergillus spp., Scedosporium spp., and Fusarium spp.

Precaution

Patients with potentially proarrhythmic conditions, risk for acute pancreatitis. Correct electrolyte disturbances e.g. hypokalaemia, hypomagnesaemia and hypocalcaemia prior to treatment. Hepatic and renal impairment. Pregnancy and lactation.

Interaction

Increased prothrombin time w/ oral anticoagulants. May increase plasma concentrations of ciclosporin and tacrolimus, long-acting opiates (e.g. oxycodone, methadone), NSAIDs (e.g. ibuprofen, diclofenac), omeprazole, short-acting opiates (e.g. alfentanil, fentanyl). Decreased voriconazole plasma concentration and increased phenytoin plasma concentrations when used concomitantly. May increase plasma concentration with oral contraceptives.

Pregnancy Lactation use

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Contraindication

Hypersensitivity. Co-admin with CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide, quinidine, rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital, mephobarbital), ergot alkaloids (e.g. ergotamine and dihydroergotamine), efavirenz (≥400 mg once daily), ritonavir (≥400 mg bid), sirolimus, rifabutin, St John's wort.

Special Warning

 

Acute Overdose

Symptom: Photophobia. Management: May remove via haemodialysis.

Interaction with other Medicine

 

Storage Condition

Tablet: Store between 15-30° C. Powd for oral susp: Store between 2-8°C. Reconstituted oral susp: Store between 15-30° C (do not refrigerate or freeze), stable for up to 14 days.

Voxpert Tablet price in India 3060

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