Tyzocort contains Deflazacort. Tyzocort uses:

  • Anaphylaxis, asthma, severe hypersensitivity reactions
  • Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica
  • Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyarteritis nodosa, sarcoidosis
  • Pemphigus, bullous pemphigoid, pyoderma gangrenosum
  • Minimal change nephrotic syndrome, acute interstitial nephritis
  • Rheumatic carditis
  • Ulcerative colitis, Crohn's disease
  • Uveitis, optic neuritis
  • Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
  • Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma
  • Immune suppression in transplantation
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Brand Name: Tyzocort
Generic: Deflazacort
Weight: 6.0 Mg
Type: Tablet
Therapeutic Class: Glucocorticoids
Manufacturer: VASU ORGANICS PVT LTD
Price: 112
Last Updated: 2020-11-20 18:15:00

Doses

Tyzocort contains Deflazacort 6.0 Mg. Tyzocort doses

Adults:

  • For acute disorders: up to 120 mg/day Tyzocort may need to be given initially. Maintenance doses in most conditions are within the range 3-18 mg/day.
  • Rheumatoid arthritis: The maintenance dose is usually within the range 3-18 mg/day. The smallest effective dose should be used and increased if necessary.
  • Bronchial asthma: In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled. For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms.
  • Other conditions: The dose of Tyzocort depends on clinical need titrated to the lowest effective dose for maintenance. Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg Tyzocort.

Children: 

Alternate day administration may be appropriate.  Doses of Tyzocort usually lie in the range 0.25-1.5 mg/kg/day. The following ranges provide general guidance:

  • Juvenile chronic arthritis: The usual maintenance dose is between 0.25 to 1.0 mg/kg/day.
  • Nephrotic syndrome: Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need.
  • Bronchial asthma: The initial dose should be between 0.25 - 1.0 mg/kg on alternate days.
  • Tyzocort withdrawal: In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.

 

Side Effects

After administration occasionally GI disturbances like dyspepsia, nausea; musculoskeletal disorders like myopathy; depressed mood, skin atrophy, acne etc. may occur.

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Introduction

Tyzocort provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides Tyzocort decreases the release of certain chemicals that are important in the immune system. By decreasing the release of these chemicals Tyzocort provides immunosuppressive action.

Precaution

The following clinical conditions require special caution and frequent patient monitoring is necessary: Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent myocardial infarction, congestive heart failure, liver failure, renal impairment, diabetes mellitus and glaucoma (including family history), osteoporosis, corneal perforation, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.

Interaction

Tyzocort is metabolized in the liver. It is recommended to increase the maintenance dose of Tyzocort if drugs which are liver enzyme inducers are co-administered, e.g. rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone and aminoglutethimide. For drugs which inhibit liver enzymes, (e.g. ketoconazole) it may be possible to reduce the maintenance dose of Tyzocort.

Pregnancy Lactation use

Use in pregnancy: Tyzocort does cross the placenta. When administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.

Use in lactation: Corticosteroids are excreted in breast milk. Doses up to 50 mg daily of Tyzocort are unlikely to cause systemic effects in the infant.

Contraindication

Hypersensitivity to or any of the ingredients. Patients receiving live virus immunisation.

Special Warning

Elderly: In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.

Hepatic impairment: In patients with hepatic impairment, blood levels of Tyzocort may be increased. Therefore the dose of Tyzocort should be carefully monitored and adjusted to the minimum effective dose.

Renal impairment: In renal impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.

Acute Overdose

In patients who have received more than physiological doses of systemic corticosteroids (approximately 9mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should becarried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.

Interaction with other Medicine

 

Storage Condition

Store in a cool (below 25° C.) and dry place , protected from light & moisture. Keep out of the reach of children.

Tyzocort Tablet price in India 112

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