Torlica Plus Ls contains Spironolactone. Torlica Plus Ls uses:

Torlica Plus Ls is indicated in Congestive heart failure, Hepatic cirrhosis with ascites and oedema, Nephrotic syndrome, Primary hyperaldosteronism, Essential hypertension, For the treatment of patients with hypokalemia

Torlica Plus Ls is a long-acting aldosterone antagonist. Torlica Plus Ls is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone dependent sodium-potassium exchange site in the distal convoluted renal tubule. Torlica Plus Ls causes increased amounts of sodium and water to be excreted, while potassium and magnesium is retained.

Ads
Brand Name: Torlica Plus Ls
Generic: Spironolactone
Weight: 25.0 Mg
Type: Tablet
Therapeutic Class: Potassium-sparing diuretics, Potassium-sparing diuretics & Aldosterone antagonists
Manufacturer: ELICAD PHARMACEUTICALS PVT LTD
Price: 36.55
Last Updated: 2020-11-20 18:15:00

Doses

Torlica Plus Ls contains Spironolactone 25.0 Mg. Torlica Plus Ls doses

Edema in adults (congestive heart failure, hepatic cirrhosis, or nephrotic syndrome): An initial daily dosage of 100 mg of Torlica Plus Ls administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. Combined therapy with other diuretics is indicated when more rapid diuresis is desired.

Primary hyperaldosteronism: After the diagnosis of hyperaldosteronism has been established, Torlica Plus Ls may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, Torlica Plus Ls may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient.

Essential hypertension: For adults, an initial daily dosage of 50 to 100 mg of Torlica Plus Ls administered in either single or divided doses is recommended.

Hypokalemia: Torlica Plus Ls in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia.

 

Side Effects

Gynaecomastia may develop in association with the use of Torlica Plus Ls. Other adverse reactions are: GI symptoms including cramping and diarrhoea, drowsiness, lethargy, headache, urticaria, mental confusion, impotence, irregular menses or amenorrhoea and post-menopausal bleeding.

Ads
Introduction

Torlica Plus Ls is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Torlica Plus Ls causes increased amounts of sodium and water to be excreted, while potassium is retained. Torlica Plus Ls acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+ K+ ATPase and the Na+ channel involved in a Na+ K+transport in the distal tubule . Torlica Plus Ls bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

Precaution

All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance. Hyperkalemia may occur in patients with impaired renal function or excessive potassium intake and can cause cardiac irregularities, which may be fatal.

Interaction

ACE inhibitors: Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia.

Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.

Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur.

Lithium: Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Digoxin: Torlica Plus Ls has been shown to increase the half-life of digoxin.

Pregnancy Lactation use

Pregnancy: Torlica Plus Ls should not be used during pregnancy

Lactation: Canrenone, an active metabolite of Torlica Plus Ls, appears in breast milk. If use of the drug is deemed essential an alternative method of infant feeding should be instituted.

Contraindication

Torlica Plus Ls is contraindicated in patients with acute renal insufficiency, significant impairment of renal function, anuria, hyperkalaemia or sensitivity to Torlica Plus Ls.

Special Warning

 

Acute Overdose

Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Patients should induce vomiting or evacuate the stomach by lavage during Torlica Plus Ls overdoasge.

Interaction with other Medicine

 

Storage Condition

Store in a cool and dry place protected from light. Keep out of reach of children.

Torlica Plus Ls Tablet price in India 36.55

Ads