Riptin contains Amitriptyline + Chlordiazepoxide. Riptin uses:

Depression with Anxiety, agitation or tension.

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Brand Name: Riptin
Generic: Amitriptyline + Chlordiazepoxide
Weight: 10.0 Mg
Type: Tablet
Therapeutic Class: Combined anxiolytics & anti-depressant drugs
Manufacturer: NEURO LIFE SCIENCE
Price: 15.3
Last Updated: 2020-11-21 18:15:00

Doses

Riptin contains Amitriptyline + Chlordiazepoxide 10.0 Mg. Riptin doses

1 tablet (5 mg chlordiazepoxide and 12.5 mg amitriptyline) three to four times daily; may increase to 6 tablets if necessary

 

Side Effects

Drowsiness, Dry mouth, Constipation, Blurred vision, Dizziness, Bloating, Vivid dreams, Impotence, Tremor, Confusion, Nasal congestion, Edema, Syncope, Ataxia, EEG abnormalities, Menstrual irregularities, Blood dyscrasias (agranulocytosis), Hepatic dysfunction (jaundice).

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Introduction

Chlordiazepoxide: Chlordiazepoxide enhances activity of the inhibitory transmitter GABA in different parts of CNS by increasing neuronal-membrane permeability to chloride ions resulting to hyperpolarisation and stabilisation. It has some muscle relaxant and anticonvulsant activity.

Amitriptyline: Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Precaution

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (age <24 yr) taking antidepressants for major depressive disorders and other psychiatric illnesses.

Caution in BPH, urinary/GI retention, increased IOP, thyroid dysfunction, open-angle glaucoma, seizure disorders, brain tumor, respiratory impairment, respiratory disease. Risk of anticholinergic side-effects. May cause orthostatic hypotension. Paradoxical reactions including hyperactive or aggressive behavior reported.

Both agents may cause sedation and impair ability to perform tasks requiring mental alertness. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; monitor during the initial 1 -2 months of therapy and dosage adjustments.

Not approved for treatment of dementia-related psychosis.

Interaction

 

Pregnancy Lactation use

Pregnancy Category D. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation: Excretion in milk unknown; not recommended

Contraindication

Hypersensitivity. Severe cardiovascular disorders, Angle clossure glaucoma, Within 14 days of MAOIs, Any drugs or conditions that prolong QT interval, Acute recovery post-MI.

Special Warning

 

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

 

Riptin Tablet price in India 15.3

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