Mesacol Cr Granule 1*1 contains Mesalazine (5-aminosalicylic acid). Mesacol Cr Granule 1*1 uses:
This medication is used to treat a certain bowel disease (ulcerative colitis). It helps to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain. Mesalamine belongs to a class of drugs known as aminosalicylates.This medication may also be used to treat Crohn's disease.
|Brand Name:||Mesacol Cr Granule 1*1|
|Generic:||Mesalazine (5-aminosalicylic acid)|
|Therapeutic Class:||Anti-Tubercular Chemotherapeutics, Ulcerative Colitis|
|Last Updated:||2020-11-20 18:15:00|
Mesacol Cr Granule 1*1 contains Mesalazine (5-aminosalicylic acid) 2.0 G. Mesacol Cr Granule 1*1 doses
Child (5-15 year):
Should be taken on an empty stomach: Take 1 hr before meals. Swallow whole, do not chew/crush.
Abdominal pain, diarrhea, flatulence, nausea, vomiting. Tab: Renal impairment, acute & chronic interstitial nephritis, renal insufficiency; exanthema, drug fever, bronchospasm, pericarditis & myocarditis, pancreatitis, allergic & fibrotic lung reactions including dyspnoea, cough, alveolitis, pulmonary eosinophilia, lung infiltration, pneumonitis, butterfly rash (lupus erythematosus syndrome), pancolitis; myalgia, arthralgia; aplastic anaemia, agranulocytosis, pancytopenia, neutropenia, leucopenia, thrombocytopenia; raised transaminase & parameters of cholestasis, hepatitis, cholestatic hepatitis; alopecia; reversible oligospermia. Enema: Allergic exanthema, drug fever; bronchospasm; lupus erythematosus-like syndrome. Granules: Headache, dizziness; pericarditis. Supp: Allergic skin rash, fever, breathing difficulty.
Although the mechanism of action of mesalazine is not fully understood, it appears to be topical rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
Use with caution, usually starting at the low end of the dosage range, because of the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant diseases or other drug therapy.
Hypersensitivity: Some patients who have experienced a hypersensitivity reaction to sulfasalazine may have a similar reaction to mesalamine.
Renal Function: Patients with history of renal function impairment or disease may have worsening of renal function.
Hepatic Function: Use with caution. There have been reports of hepatic failure in patients with preexisting liver disease.
Sulfite Sensitivity: Some products may contain sulfites, which may cause allergic reactions in susceptible individuals.
Antacids: Because the dissolution of the coating of Apriso granules depends on pH, do not administer with antacids.
Nephrotoxic agents (including NSAIDs): Increased risk of renal adverse reactions.
Thiopurines (eg, azathioprine, mercaptopurine): Risk of leukopenia may be increased.
Warfarin: Decreased anticoagulant effect of warfarin has been reported in 1 patient.
Laboratory Test Interactions: None well documented.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Lactation: Excreted in breast milk.
Hypersensitivity to salicylates, aminosalicylates, or any component of the product.
Renal Impairment: CrCl <20 Dosage Avoid.
Hepatic Impairment: Avoid in severe impairment.
Products are salicylates; symptoms of salicylate toxicity may include confusion, deafness, dehydration, diarrhea, drowsiness, dyspnea, electrolyte and blood pH imbalance, headache, hematemesis, hyperpnea, hyperthermia, hyperventilation, lethargy, seizures, sweating, tachypnea, tinnitus, vertigo, vomiting.
Tablet: store at below 25° C.
Capsule: protect from light and store at 15-30° C.
Mesacol Cr Granule 1*1 price in India 57.8