Mecozen Gb contains Gabapentin. Mecozen Gb uses:

Mecozen Gb is indicated for-

  • Epilepsy
  • Neuropathic pain (e.g. postherpetic neuralgia) and other pain conditions
  • Bipolar disorder
  • Headache syndrome
  • Spasticity in multiple sclerosis and spinal cord diseases

Others indication are:

  • Alcohol withdrawal
  • Schizoaffective disorder
  • Post-traumatic stress disorder
  • Agitation and behavioural disturbances
  • associated with dementia
  • Lesch-Nyhan syndrome
  • Essential tremor
  • Restless legs syndrome
  • Brachioradial pruritus
  • Hemichorea/hemiballismus
  • Hot Flashes
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Brand Name: Mecozen Gb
Generic: Gabapentin
Weight: 300.0 Mg
Type: Tablet
Therapeutic Class: Adjunct anti-epileptic drugs
Manufacturer: SAIN MEDICAMENTS PVT LTD
Price: 102
Last Updated: 2020-11-22 18:15:00

Doses

Mecozen Gb contains Gabapentin 300.0 Mg. Mecozen Gb doses

Neuropathic pain: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 1800 mg daily in three divided doses.

Partial seizure/epilepsy: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 2400 mg daily in three divided doses. 

In case of children: 

  • For 3-12 years: 10 to 15 mg/kg, Incase of titration 25-35 mg/kg daily in 3 divided doses.
  • Maintenance dose is 900 mg daily (body weight 26-36 Kg) or 1.2 gm daily (body weight 37-50 Kg).

Mecozen Gb can be taken orally with or without food.

Side Effects

Generally Mecozen Gb is well tolerated but a few side effects like fatigue, dizziness , ataxia, weight gain, peripheral edema, dry mouth and somnolence, may occur. Rarely it may cause fulminate hepatic failure, or aplasticanemia.

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Introduction

Mecozen Gb is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Mecozen Gb are due to the activity of parent compound. Mecozen Gb binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.

Precaution

Patients should be instructed to take Mecozen Gb only as prescribed. While using Mecozen Gb patients should be instructed either not to drive a car or to operate other complex machinery until they have gained sufficient experiences about Mecozen Gb whether or not it affects their mental and/or motor performance adversely.

Interaction

Antacids may reduce the bioavailability of Mecozen Gb by up to 20%. Cimetidine may alter its reanal excretion. Mecozen Gb does not interact with other anti-epileptic drug or with oral contraceptive preparations.

Pregnancy Lactation use

Pregnancy: Mecozen Gb is a pregnancy category C drug; it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: Mecozen Gb may be secreted through the breast milk like many other drugs , so it should be used in women who are nursing, only if the benefits clearly outweigh the risks.

Contraindication

Mecozen Gb is contraindicated in patients who have known hypersensitivity to the drug.

Special Warning

Use in Children: Safety and effectiveness of Mecozen Gb in the management of neuropathic pain in pediatric patients have not been established. Safety and effectiveness of Mecozen Gb in the management of seizures in pediatric patients below the age of 3 years have not been established.

Renal impaired patient: In case of renal impaired patient Mecozen Gb doses must be reduced : 

  • CrCl >60 ml/min: 1200 mg/daily in 3 divided doses
  • CrCl 30-60 ml/min: 600 mg/daily in 2 divided doses
  • CrCl 15-30 ml/min: 300 mg/daily single dose
  • CrCl <15 ml/min: 150 mg/daily single dose or 300 mg/every alternate day
  • Heamodialysis: maximum 300 mg after each dialysis Mecozen Gb can be taken orally with or without food.
Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

Tablets should be stored below 25° C and protected from light & moisture

Mecozen Gb Tablet price in India 102

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