Liveril U contains Ursodeoxycholic Acid. Liveril U uses:

Liveril U is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

Ursodeoxycholic acid is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones. The cholesterol saturation of bile is reduced by Ursodeoxycholic acid, allowing gradual solubilization of cholesterol gallstones. Cholesterol of secretion into bile is reduced and bile acid secretion rate is increased during Ursodeoxycholic acid treatment without a reduction in phospholipids.

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Brand Name: Liveril U
Generic: Ursodeoxycholic Acid
Weight: 150.0 Mg
Type: Tablet
Therapeutic Class: Anti-gallstones drugs: Bile Acids
Manufacturer: MEYER ORGANICS PVT LTD
Price: 153
Last Updated: 2020-11-21 18:15:00

Doses

Liveril U contains Ursodeoxycholic Acid 150.0 Mg. Liveril U doses

Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses

PBC: 10-15 mg/kg/day in 2-4 divided doses

Acute Viral Hepatitis: 600 mg/day

Alcoholic Fatty Liver: 300 mg/day

PSC: 25-30 mg/kg/day

NASH: 13-15 mg/kg/day

 

Side Effects

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.

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Introduction

Liveril U is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Liveril U is achieved through a decrease in secretion of cholesterol in bile. Liveril U achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.

Therefore, alters bile composition from supersaturated to unsaturated. Liveril U also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Liveril U improves cholestatic liver diseases by-

  • Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids
  • Stimulating hepatobilliary secretion
  • Protecting hepatocytes against bile acid-induced apoptosis

Liveril U is completely absorbed in the upper intestine. Time to peak serum concentration varies from 30 to 150 minutes. The rate of absorption ranges from 60-80%. After absorption Liveril U enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Liveril U appear in the circulation and very small amounts are excreted into urine. The biologic half life of Liveril U ranges from 3.5-5.8 days.

Precaution

It should be used cautiously in those with liver disease.

Interaction

Liveril U should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.

Pregnancy Lactation use

Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.

Contraindication

Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.

Special Warning

 

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.

Liveril U Tablet price in India 153

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