Lacotab contains Lacosamide. Lacotab uses:

Lacotab is indicated for the treatment of partial-onset seizures in patients 4 years of age and older. As the safety of Lacotab injection has not been established in pediatric patients, Lacotab injection is indicated for the treatment of partial-onset seizures only in adult patients (17 years of age and older)

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Brand Name: Lacotab
Generic: Lacosamide
Weight: 100.0 Mg
Type: Tablet
Therapeutic Class: Atypical anti-depressant drugs
Manufacturer: ALTEUS BIOGENICS PVT LTD
Price: 112.2
Last Updated: 2020-11-20 18:15:00

Doses

Lacotab contains Lacosamide 100.0 Mg. Lacotab doses

Adults (17 years and older): Initial dosage for monotherapy is 100 mg twice daily; initial dosage for adjunctive therapy is 50 mg twice daily; maximum recommended dosage for monotherapy and adjunctive therapy is 200 mg twice daily 

Pediatric Patients 4 Years to less than 17 years: The recommended dosage is based on body weight and is administered orally twice daily. Increase dosage based on clinical response and tolerability, no more frequently than once per week

Injection: for intravenous and adult use only when oral administration is temporarily not feasible; dosing regimen is the same as oral regimen; administer over 15 to 60 minutes; obtaining ECG before initiation is recommended in certain patients

 

Side Effects

Adjunctive therapy: Most common adverse reactions in adults (≥10% and greater than placebo) are diplopia, headache, dizziness, nausea

Monotherapy: Most common adverse reactions are similar to those seen in adjunctive therapy studies

Pediatric patients: Adverse reactions are similar to those seen in adult patients

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Introduction

It is proposed that lacosamide's inhibition of sodium channels is responsible for analgesia. Lacotab may be selective for inhibiting depolarized neurons rather than neurons with normal resting potentials. Pain and nociceptor hyperexcitability are associated with neural membrane depolarization. Lacotab binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein which is expressed primarily in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. The role CRMP-2 of binding in seizure control is hasn't been elucidated.

Precaution

Monitor patients for suicidal behavior and ideation    

Lacotab may cause dizziness and ataxia    

Cardiac Rhythm and Conduction Abnormalities: Obtaining ECG before beginning and after titration to steady-state maintenance is recommended in patients with known cardiac conduction problems, taking drugs known to induce PR interval prolongation, or with severe cardiac disease; closely monitor these patients    

Lacotab may cause syncope    

Lacotab should be gradually withdrawn to minimize the potential of increased seizure frequency    

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multi-Organ Hypersensitivity: Discontinue if no alternate etiology

Interaction

Strong CYP3A4 or CYP2C9 Inhibitors: Patients with renal or hepatic impairment who are taking strong inhibitors of CYP3A4 and CYP2C9 may have a significant increase in exposure to Lacotab. Dose reduction may be necessary in these patients.

Concomitant Medications that Prolong PR Interval: Lacotab should be used with caution in patients on concomitant medications that prolong PR interval, because of a risk of AV block or bradycardia, e.g., beta-blockers and calcium channel blockers. In such patients, obtaining an ECG before beginning Lacotab, and after Lacotab is titrated to steady-state, is recommended. In addition, these patients should be closely monitored if they are administered Lacotab through the intravenous route

Pregnancy Lactation use

Pregnancy: Based on animal data, may cause fetal harm

Contraindication

None

Special Warning

Dose adjustment is recommended for severe renal impairment. Dose adjustment is recommended for mild or moderate hepatic impairment; use in patients with severe hepatic impairment is not recommended

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

Store at 20°C to 25°C

Lacotab Tablet price in India 112.2

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