Fenofibron contains Fenofibrate. Fenofibron uses:

Fenofibron is indicated as an adjunct to diet and other non pharmacological treatment (e.g. exercise, weight reduction) for the following:

  • Treatment of severe hypertriglyceridemia with or without low HDL cholesterol.
  • Mixed hyperlipidemia when a statin is contraindicated or not tolerated.
  • Mixed hyperlipidemia in patients at high cardiovascular risk in addition to a statin when triglycerides and HDL cholesterol are not adequately controlled
Brand Name: Fenofibron
Generic: Fenofibrate
Weight: 145.0 Mg
Type: Tablet
Therapeutic Class: Fibrates
Price: 89.25
Last Updated: 2020-11-22 18:15:00


Fenofibron contains Fenofibrate 145.0 Mg. Fenofibron doses

The dose is one 200 mg capsule per day. Dosage should be individualized according to patient response, and should be increased sequentially if necessary following repeat serum triglyceride estimations at 4 to 8 week intervals. Patients should be placed on an appropriate triglyceride-lowering diet before receiving fenofibrate, and should continue this diet during treatment with fenofibrate. Fenofibron should be given with meals, thereby optimizing the bioavailability of the medication.


Side Effects

Digestive: hepatitis, cholelithiasis, cholecystitis, hepatomegaly

Musculoskeletal: myalgia, myasthenia, rhabdomyolysis

Skin and appendages: photosensitivity, eczema

Cardiovascular: peripheral edema, angina, palpitations, tachycardia, and migraine


Fenofibron is a fibric acid derivative, a prodrug comprising fenofibric acid linked to an isopropyl ester. Fenofibron is rapidly hydrolyzed after oral ingestion to its pharmacologically active form, fenofibric acid. The effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα)

It lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein CIII (an inhibitor of lipoprotein lipase activity), which increases lipolysis and elimination of triglyceride-rich particles from plasma. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly

PPARα also increases apoproteins AI and AII, reduces VLDL- and LDL-containing apoprotein B, and increases HDL-containing apoprotein AI and AII. Fenofibron also reduces serum uric acid levels in hyperuricemic and normal individuals by increasing the urinary excretion of uric acid.


Increased risk of cholelithiasis, pancreatitis, skeletal muscle effects. Patient at risk of rhabdomyolysis. Renal impairment. Pregnancy.


Oral Anticoagulants: Caution should be exercised when anticoagulants are given in conjunction with fenofibrate. The dosage of the anticoagulants should be reduced to maintain the prothrombin time at the desired level to prevent bleeding complications.

Resins: Since bile acid sequestrants may bind other drugs given concurrently, patients should take fenofibrate at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impending its absorption.

Cyclosporine: Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including fenofibrate, there is a risk that an interaction will lead to deterioration.

Pregnancy Lactation use

Pregnancy Category C. Fenofibron should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing mothers: Fenofibron should not be used in nursing mothers. Because of the potential for tumorigenicity seen in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug.


Fenofibron is contraindicated in patients with-

  • Hypersensitivity to fenofibrate or any component of this medication.
  • Known photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen.
  • Severe liver dysfunction, gallbladder disease, biliary cirrhosis, severe renal disorders.
  • Chronic or acute pancreatitis with the exception of acute pancreatitis due to severe hypertriglyceridemia.
  • Pregnancy and lactation.
Special Warning

Geriatrics: This indicates that a similar dosage regimen can be used in the elderly, without increasing accumulation of the drug or metabolites.

Pediatrics: No data are available. Fenofibron is not indicated for use in the pediatric population.

Gender: No pharmacokinetic difference between male and female has been observed for fenofibrate.

Renal insufficiency: The dosage of fenofibrate should be minimized in patients who have severe renal impairment, while no modification of dosage is required in patients having moderate renal impairment.

Hepatic insufficiency: No pharmacokinetic study has been conducted in patients having hepatic insufficiency.

Acute Overdose


Interaction with other Medicine


Storage Condition

Store at cool & dry place. Protect from light and moisture.

Fenofibron Tablet price in India 89.25