Epocarb Od contains Oxcarbazepine. Epocarb Od uses:

Epocarb Od is indicated for:

Adults: Monotherapy or adjunctive therapy in the treatment of partial seizures


  • Monotherapy in the treatment of partial seizures in children 4-16 years
  • Adjunctive therapy in the treatment of partial seizures in children 2–16 years
Brand Name: Epocarb Od
Generic: Oxcarbazepine
Weight: 300.0 Mg
Type: Tablet
Therapeutic Class: Adjunct anti-epileptic drugs
Price: 66.3
Last Updated: 2020-11-21 18:15:00


Epocarb Od contains Oxcarbazepine 300.0 Mg. Epocarb Od doses

Adults: initiate with a dose of 600 mg/day, given twice-a-day

  • Adjunctive Therapy: Maximum increment of 600 mg/day at approximately weekly intervals. The recommended daily dose is 1200 mg/day
  • Conversion to Monotherapy: withdrawal concomitant over 3 to 6 weeks;reach maximum dose of Epocarb Od in 2 to 4 weeks with increments of 600 mg/day at weekly intervals to a recommended daily dose of 2400 mg/day
  • Initiation of Monotherapy: Increments of 300 mg/day every third day to a dose of 1200 mg/day.
  • Creatinine Clearance <30 mL/min: Initiate at one half the usual starting dose and increase slowly

Pediatrics: initiation with 8 to 10 mg/kg/day, given twice-a-day. For patients aged 2 to <4 years and under 20 kg, a starting dose of 16 to 20 mg/kg/day may be considered. Recommended daily dose is dependent upon patient weight.

  • Adjunctive Patients (Aged 2–16 Years): For patients aged 4 to 16 years, target maintenance dose should be achieved over 2 weeks. For patients aged 2 to <4 years, maximum maintenance dose should be achieved over 2 to 4 weeks and should not to exceed 60 mg/kg/day
  • Conversion to Monotherapy for Patients (Aged 4-16 Years): Maximum increment of 10 mg/kg/day at weekly intervals, concomitant antiepileptic drugs can be completely withdrawn over 3 to 6 weeks
  • Initiation of Monotherapy for Patients (Aged 4–16 Years): Increments of 5 mg/kg/day every third day


Side Effects

The most commonly reported adverse reactions are somnolence, headache, dizziness, diplopia, nausea; vomiting and fatigue. Very rarely clinically significant hyponatraemia can develop during Oxazep use. Class I (immediate) hypersensitivity reactions including rash, pruritus, urticaria, angioedema and reports of anaphylaxis have been received.


The pharmacological activity of Epocarb Od is primarily exerted through the metabolite derivative (the monohydroxy derivative, MHD) of Epocarb Od. The mechanism of action of Epocarb Od and MHD is thought to be mainly based on blockade of voltage-sensitive sodium channels, thus resulting in stabilization of hyper excited neural membranes, inhibition of repetitive neuronal firing and diminishment of propagation of synaptic impulses.


Alcohol: Caution should be exercised if alcohol is taken in combination with Oxazep therapy, due to a possible additive sedative effect.

Withdrawal: As with all antiepileptic medicinal products, Oxazep should be withdrawn gradually to minimise the potential of increased seizure frequency.


Epocarb Od and its metabolite inhibit the enzyme CYP2C19 and therefore, interactions could arise when co-administering high doses of Oxazep with medicinal products that are metabolised by CYP2C19 (e.g. phenobarbital, phenytoin). Concurrent use of Oxazep with hormonal contraceptives may render few contraceptives ineffective (e.g. Ethinylestradiol and Levonorgestrel preparations). Co-administration of Oxazep lowers AUC of felodipine and Verapamil decreases bioavailability of MHD.

Pregnancy Lactation use

Pregnancy: Data on a limited number of pregnancies indicate that Epocarb Od may cause serious birth defects (e.g. cleft palate) when administered during pregnancy. In the newborn child. Bleeding disorders in the newborn caused by antiepileptic agents have been reported. As a precaution, vitamin K1 should be administered as a preventive measure in the last few weeks of pregnancy and to the newborn. Epocarb Od and its active metabolite (MHD) cross the placenta. Neonatal and maternal plasma MHD concentrations were similar in one case.

Lactation: Epocarb Od and its active metabolite (MHD) are excreted in human breast milk. Therefore, Oxazep should not be used during breast-feeding.


It is contraindicated to patients with hypersensitivity to the active substance or to any of the excipients.

Special Warning


Acute Overdose


Interaction with other Medicine


Storage Condition


Epocarb Od Tablet price in India 66.3