Ampclox contains Dicloxacillin. Ampclox uses:
Ampclox is indicated in Boils, Carbuncles, Cellulitis, Endocarditis, Folliculitis, Impetigo, Mastitis, Osteomyelitis, Otitis externa, Pneumonia, Septic Arthritis, Staphylococcal skin infections, Streptococcus Septicaemia, Surgical Prophylaxis, Throat infections
|Therapeutic Class:||Penicillinase-resistant penicillins|
|Last Updated:||2020-11-22 18:15:00|
Ampclox contains Dicloxacillin 250.0 Mg. Ampclox doses
Adult: 125-250 mg 6 hourly. Doses may be doubled in severe infections.
Child: <40 kg: 12.5-25 mg/kg 6 hourly.
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Hypersensitivity reactions (e.g. urticaria, fever, joint pains, rashes, angioedema, serum sickness-like reactions), nausea, vomiting, diarrhoea, stomatitis, black/hairy tongue, neurotoxic reactions, renal tubular damage, interstitial nephritis, eosinophilia, haemolytic anaemia, agranulocytosis, neutropenia, leucopenia, granulocytopenia, bone marrow depression, hepatotoxicity, cholestatic hepatitis.
Ampclox inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Patient with history of allergy esp β-lactam allergy, asthma. Pregnancy and lactation.
Probenecid prolongs serum levels of dicloxacillin. Bacteriostatic drugs (e.g. chloramphenicol, tetracyclines) may antagonise the bactericidal effect of dicloxacillin. May reduce anticoagulant response to dicumarol and warfarin. May increase risk of methotrexate toxicity. May diminish the effect of live vaccines (e.g. typhoid vaccine).
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Hypersensitivity to dicloxacillin and other penicillins.
Store between 20-25° C.
Ampclox Capsule price in India 78.2