Zydol SR
Zydol SR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zydol SR is a brand name. Its generic name is Tramadol.
Zydol SR
Zydol SR, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Zydol SR also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Zydol SR is available in both immediate-release and extended-release forms.
Uses For Zydol SR
Zydol SR is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Zydol SR is sometimes prescribed for the treatment of opioid dependence.
Mechanism Of Action
Zydol SR works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Zydol SR also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.
How Long Does It Take To Work?
Zydol SR typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.
Absorption
Zydol SR is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.
Route Of Elimination
Zydol SR is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.
Dosage
Dosage of Zydol SR depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.
Administration
Zydol SR can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.
Side Effect
Common side effects of Zydol SR include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.
Toxicity
Zydol SR is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.
Precautions
Zydol SR should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Zydol SR should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.
Interaction
Zydol SR may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.
Disease Interaction
Zydol SR may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.
Drug Interaction
Zydol SR can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.
Food Interactions
Zydol SR should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.
Pregnancy Use
Zydol SR is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.
Lactation Use
Zydol SR should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.
Acute Overdose
Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.
Contraindication
Zydol SR is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.
Use Direction
Zydol SR should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.
Storage Condition
Zydol SR should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.
Volume Of Distribution
Zydol SR has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.
Half Life
Zydol SR has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.
Clearance
Zydol SR has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.
Here you find in details version of Zydol SR
Some Frequently Asked Questions About Zydol SR
What is Zydol SR?
Zydol SR is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.
What is the generic name of Zydol SR?
Zydol SR's generic name is Ultram.
What is the mechanism of action of Zydol SR?
Zydol SR works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.
Is Zydol SR a controlled substance?
Yes, Zydol SR is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.
How fast does Zydol SR work?
Zydol SR works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.
How should Zydol SR be taken?
Zydol SR should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.
What are the side effects of Zydol SR?
The most common side effects of Zydol SR include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.
Can I take acetaminophen and Zydol SR together?
Yes, acetaminophen and Zydol SR can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.
What are the signs of an overdose of Zydol SR?
Signs of an overdose of Zydol SR include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.
Can Zydol SR be used for back pain?
Yes, Zydol SR is often prescribed for the treatment of back pain.
Is Zydol SR addictive?
Yes, Zydol SR can be addictive when taken in large amounts or for long periods of time.
What should I do if I forget to take a dose of Zydol SR?
If you forget to take a dose of Zydol SR, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can Zydol SR be taken with alcohol?
No, Zydol SR should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.
Should I avoid caffeine while taking Zydol SR?
Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.
Is Zydol SR safe for long-term use?
Zydol SR is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.
Can Zydol SR be taken during pregnancy?
Zydol SR should not be taken during pregnancy as it can cause harm to the fetus.
Can I take Zydol SR if I have a history of drug abuse?
No, Zydol SR should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.
Will Zydol SR show up on a drug test?
Yes, Zydol SR may show up on a drug test, though the results may vary depending on the type of test.
Can I take Zydol SR if I have liver or kidney disease?
Zydol SR should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.
Can I take Zydol SR with anti-anxiety medications?
No, Zydol SR should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.
What should I do if I experience any side effects from Zydol SR?
If you experience any side effects from Zydol SR, contact your doctor as soon as possible.
What other pain relievers can be taken with Zydol SR?
Zydol SR can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.
What is the maximum daily dose of Zydol SR?
The maximum daily dose of Zydol SR is 400 milligrams per day for adults.
Does Zydol SR cause constipation?
Yes, constipation is a common side effect of Zydol SR.
Can I take Zydol SR and Zydol SR Plus together?
No, Zydol SR and Zydol SR Plus should not be taken together as it may increase the risk of adverse reactions.
Can Zydol SR be taken for headaches?
Yes, Zydol SR is often prescribed for the treatment of headaches.
Is Zydol SR ever prescribed for arthritis?
Yes, Zydol SR is sometimes prescribed for the treatment of arthritis.
Does Zydol SR interact with other medications?
Yes, Zydol SR may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Zydol SR.
Can Zydol SR be taken for menstrual cramps?
Yes, Zydol SR can be prescribed for the treatment of menstrual cramps.
Can Zydol SR be crushed for easier swallowing?
No, Zydol SR should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.
What other conditions can Zydol SR be used to treat?
Zydol SR may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.
Can I take Zydol SR while breastfeeding?
No, Zydol SR should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.
Can Zydol SR be taken with anti-depressants?
Yes, Zydol SR can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).
Can Zydol SR be taken with vitamins or supplements?
Yes, Zydol SR can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Zydol SR.
Can Zydol SR be taken with antihistamines?
Yes, Zydol SR can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.
Can I take Zydol SR with other pain relievers?
No, Zydol SR should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.
Is Zydol SR metabolized by the liver?
Yes, Zydol SR is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Zydol SR.
How long will Zydol SR stay in my system?
Zydol SR can stay in the system for up to 24 hours after the last dose.
What should I do if I miss a dose of Zydol SR?
If you miss a dose of Zydol SR, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can I take Zydol SR while taking other medications?
Yes, Zydol SR can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Zydol SR.
Does Zydol SR affect blood pressure?
Yes, Zydol SR may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.
What is Zydol SR HCL?
Zydol SR HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.
What are the withdrawal symptoms of Zydol SR?
The withdrawal symptoms of Zydol SR may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.
Can Zydol SR cause hallucinations?
Yes, Zydol SR can cause hallucinations, especially at higher doses.
Is Zydol SR the same as Vicodin?
No, Zydol SR and Vicodin are different medications. Zydol SR is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.
Can Zydol SR be taken with other medications for pain?
Yes, Zydol SR can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Zydol SR.