Zeum
Zeum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zeum is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Zeum (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Zeum is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Zeum works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Zeum can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Zeum is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Zeum is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Zeum is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Zeum should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Zeum may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Zeum use, however it can cause serious side effects in certain individuals.Precautions
- Zeum should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Zeum may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Zeum should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Zeum may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Zeum alongside any other medications.Food Interactions
Food interactions with Zeum are not known.Pregnancy Use
Zeum should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Zeum is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Zeum is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Zeum is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Zeum should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Zeum is not known.Half-Life
The half-life of Zeum is approximately 22 days.Clearance
The clearance of Zeum is not known.Here you find in details version of Zeum
Some Frequently Asked Questions About Zeum
you can give answe only.What is Zeum?
Zeum is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Zeum?
The chemical name of Zeum is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Zeum taken?
Zeum is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Zeum?
The most common side effects of Zeum include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Zeum?
The recommended dose of Zeum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Zeum be used?
Zeum should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Zeum?
Zeum should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Zeum?
An overdose of Zeum can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Zeum is a medical emergency and should be treated as such.
What are the interactions of Zeum with other medications?
Zeum may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Zeum?
The shelf life of Zeum is three years from the date of manufacture.
Is Zeum used for pregnant women?
The safety of Zeum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Zeum.
Is there any generic version of Zeum available?
No, there is not a generic version of Zeum available.
How long does it take for Zeum to take effect?
The effect of Zeum is usually immediate.
How often can Zeum be taken?
Zeum should not be taken more than once every six hours.
What are some alternatives to Zeum?
Alternatives to Zeum include adenosine, aminophylline, and calcium channel blockers.
Can Zeum be taken with other medications?
Yes, it is possible to take Zeum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Zeum.
Can I take Zeum if I am breastfeeding?
No, Zeum is not recommended for women who are breastfeeding.
Is Zeum safe for children?
No, Zeum should not be given to children.
Can Zeum be used for pulmonary disorders?
No, Zeum is not recommended for the treatment of pulmonary disorders.
Does Zeum interfere with other medications?
Yes, Zeum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Zeum be administered orally?
No, Zeum should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Zeum?
Zeum should not be taken more than once every six hours.
What should I do if I miss a dose of Zeum?
If you miss a dose of Zeum, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Zeum?
Common symptoms of an allergic reaction to Zeum include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Zeum with food?
Yes, it is okay to take Zeum with food.
Can I take Zeum if I’m on dialysis?
Zeum should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Zeum?
The cost of Zeum will vary depending on the dosage and the pharmacy where it is purchased.
Is Zeum habit-forming?
No, Zeum is not known to be habit-forming.
Can Zeum be used to treat arrhythmias?
Yes, Zeum is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Zeum?
The most common side effects of Zeum include dizziness, nausea, and sweating.
Does Zeum interact with other medications?
Yes, Zeum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Zeum a controlled substance?
No, Zeum is not a controlled substance.
Should I take Zeum with food?
Yes, it is okay to take Zeum with food.
Can I take Zeum if I’m pregnant?
No, the safety of Zeum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Zeum.
Can Zeum be given intramuscularly?
Yes, Zeum can be administered intramuscularly.
How should Zeum be stored?
Zeum should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Zeum?
The recommended dose of Zeum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Zeum cause drowsiness?
Yes, Zeum can cause drowsiness.
Can I take Zeum if I’m taking other medications?
Yes, it is possible to take Zeum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Zeum.
Is Zeum safe for the elderly?
Yes, Zeum is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Zeum be used to treat atrial fibrillation?
Yes, Zeum can be used to treat atrial fibrillation.
Can Zeum be used to treat ventricular tachycardia?
Yes, Zeum can be used to treat ventricular tachycardia.