Zenidine

Zenidine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Zenidine is a brand name. Its generic name is Ranitidine.

Introduction

Zenidine is a histamine-2(H2)-blocker used to treat and prevent stomach and duodenal ulcers, and to treat other stomach and gastrointestinal conditions. It is an over-the-counter drug, available both as a prescription and non-prescription medication.

Uses

Zenidine is used to treat gastrointestinal disorders such as gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excessive stomach acid. It can also be used to prevent stress ulcers, to treat heartburn, and to reduce the occurrence of stomach or duodenal ulcers

Mechanism of Action

Zenidine works by reducing the amount of acid produced by the stomach, therefore reducing the symptoms of heartburn and other gastrointestinal conditions. It does this by blocking histamine-2, which reduces the amount of acid production in the stomach in response to food.

How Long Does it Take to Work?

Zenidine begins to reduce stomach acid production and improve symptoms within a few hours or days after the first dose. The maximum benefit is usually reached within 4 weeks.

Absorption

Zenidine is well absorbed in the stomach and intestine. It has an oral absorption rate of 65-80%.

Route of Elimination

Zenidine is eliminated by the kidneys through urine via glomerular filtration and tubular secretion. Its elimination half-life is 1-2 hours.

Dosage

Zenidine is available in tablets, capsules, and suspension forms. The dosage forms and strengths are as follows:

• Tablet: 75 mg, 150 mg, and 300 mg
• Capsules: 75 mg and 150 mg
• Suspension: 10 mg/mL

The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

For treatment of esophageal reflux, the usual dose is 150 to 300 mg twice daily. For maintenance of healing of esophageal lesions, the recommended dose is 150 mg once daily.

For treatment of conditions involving excessive stomach acid, the recommended dose is 150 to 300 mg twice daily.

Administration

Zenidine can be taken with or without food. It should be taken with a full glass of water to ensure that it is completely absorbed. It is important to consume the full amount of water that is recommended for each dose.

Side Effects

Common side effects of ranitidine include headache, diarrhea, constipation, nausea, rash, dizziness, and abdominal pain. Less common side effects may include muscle pain, joint pain, fever, mental confusion, and depression.

Toxicity

Zenidine has a low toxicity and is generally well tolerated. Large doses may cause hypotension and can be fatal in cases of overdose.

Precautions

Zenidine should be used with caution in people with kidney or liver disease, and those with a history of drug allergies.

Interactions

Zenidine may interact with other medications including antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines.

Disease Interactions

Zenidine should not be used in people with porphyria, a rare metabolic disorder. It should also be used with caution in people with severe kidney disease.

Drug Interactions

Zenidine can interact with certain medications such as antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines. Be sure to discuss all medications you are taking with your healthcare provider before taking ranitidine.

Food Interactions

Zenidine may interact with food. Consuming alcohol while taking ranitidine may increase the risk of side effects such as headache, dizziness, and drowsiness.

Pregnancy Use

Zenidine should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Be sure to discuss the use of ranitidine with your healthcare provider before using it during pregnancy.

Lactation Use

Zenidine is excreted in breast milk and may affect a nursing baby. Therefore, it should be used with caution in breastfeeding women.

Acute Overdose

If an overdose of Zenidine occurs, seek medical attention immediately. Symptoms of overdose may include low blood pressure, dizziness, and unusual sleepiness.

Contraindication

Zenidine is contraindicated in people who are allergic to the active ingredient in the drug.

Use Direction

Zenidine should be taken as directed by your healthcare provider. The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

Storage Condition

Zenidine should be stored at room temperature, away from heat and moisture. Keep out of reach of children.

Volume of Distribution

The apparent volume of distribution for Zenidine is 5L/kg.

Half Life

The half-life of Zenidine is 1-2 hours.

Clearance

The clearance for Zenidine is 10 mL/min/kg.

Here you find in details version of Zenidine

Some Frequently Asked Questions About Zenidine

What is Zenidine?

Zenidine is an over-the-counter and prescription histamine-2 blocker or H2 blocker used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison Syndrome (ZES) and other conditions caused by too much acid in the stomach.

How does Zenidine work?

Zenidine works by inhibiting the production of acid in the stomach, thus reducing the symptoms of acid reflux. It can also protect the lining of the stomach from damage due to the excess stomach acid.

What is the brand name of Zenidine?

The brand name of Zenidine is Zantac.

What is the dosage of Zenidine?

The dosage of Zenidine depends on the medical condition and age of the patient; however, the usual dosage for adults in the treatment of acid reflux is 150 mg twice a day.

What are the side effects of Zenidine?

The most common side effects of Zenidine include headache, dizziness, nausea, and diarrhea. Other less common side effects include constipation, stomach pain, and rash.

Does Zenidine interact with other medications?

Yes, Zenidine can interact with other medications such as anticoagulants, sulfonylureas, and NSAIDs. Talk to your doctor or pharmacist before taking any other medication while taking Zenidine.

What is the difference between Zenidine and Famotidine?

Zenidine and Famotidine are both H2 blockers used for treating acid reflux and GERD. The main difference between them is that Zenidine is more effective for treating Zollinger-Ellison Syndrome. In terms of side effects, Zenidine may cause headaches and dizziness, while Famotidine may cause diarrhea.

Can I take Zenidine while pregnant/breastfeeding?

It is not recommended to take Zenidine while pregnant or breastfeeding as it may be harmful to the fetus or infant. Talk to your doctor before taking Zenidine during pregnancy or while breastfeeding.

How long does it take for Zenidine to work?

Zenidine usually begins to work within an hour of taking it and continues to work for up to 12 hours.

Can I take Tylenol (acetaminophen) and Zenidine together?

Yes, it is safe to take Tylenol (acetaminophen) and Zenidine together.

Is Zenidine a laxative?

No, Zenidine is not a laxative.

How should I take Zenidine?

Zenidine should be taken with or without food as prescribed by a doctor. It is important to take Zenidine exactly as prescribed and not to take more or less than recommended.

Can I take Zenidine long-term?

Zenidine can be taken long-term if it is necessary and advised by your doctor. It may be necessary to take Zenidine long-term to treat certain conditions, such as Zollinger-Ellison Syndrome.

What foods should I avoid while taking Zenidine?

It is recommended to avoid eating any food that increases the production of acid in the stomach, such as alcohol, caffeine, spicy foods, and citrus fruits while taking Zenidine.

Can Zenidine cause weight gain?

No, there is no evidence to suggest that Zenidine is linked to weight gain.

Can I take Omeprazole and Zenidine together?

No, it is not recommended to take Omeprazole and Zenidine together as they are both H2 blockers that work by suppressing acid production in the stomach.

Can I take vitamin C while taking Zenidine?

Yes, it is safe to take vitamin C while taking Zenidine.

Does Zenidine raise blood pressure?

No, there is no evidence to suggest that Zenidine is linked to increased blood pressure.

Can I take Zenidine if I have diabetes?

Yes, it is safe to take Zenidine if you have diabetes.

Can I take ibuprofen and Zenidine together?

Yes, it is safe to take ibuprofen and Zenidine together.

Can I take aspirin and Zenidine together?

Yes, it is safe to take aspirin and Zenidine together.

Does Zenidine cause constipation?

Yes, Zenidine can cause constipation in some people. If you experience constipation while taking Zenidine, it is important to contact your doctor.

Can I take Pepto-Bismol and Zenidine together?

No, it is not recommended to take Pepto-Bismol and Zenidine together as they both contain bismuth, which can have adverse effects when taken together.

What is the best time of day to take Zenidine?

The best time of day to take Zenidine depends on the dosage prescribed by your doctor. However, as a general rule, it is best to take the medication after meals or before bedtime.

Can I take Axid and Zenidine together?

No, it is not recommended to take Axid and Zenidine together as they both contain similar active ingredients and can lead to an overdose.

Can Zenidine cause liver damage?

Zenidine is not known to cause liver damage; however, if you notice any signs or symptoms of liver damage, it is important to contact your doctor immediately.

Can I take synthroid and Zenidine together?

Yes, it is safe to take synthroid and Zenidine together.

Does Zenidine cause weight loss?

No, there is no evidence to suggest that Zenidine is linked to weight loss.

Can Zenidine increase anxiety?

Yes, Zenidine can increase anxiety in some people. If you experience anxiety while taking Zenidine, it is important to contact your doctor.

Can Zenidine cause diarrhea?

Yes, Zenidine can cause diarrhea in some people. If you experience diarrhea while taking Zenidine, it is important to contact your doctor.

Can I take Prilosec and Zenidine together?

No, it is not recommended to take Prilosec and Zenidine together as they both contain similar active ingredients and can lead to an overdose.

Can I take phentermine and Zenidine together?

Yes, it is safe to take phentermine and Zenidine together.

Can I take smellaid and Zenidine together?

Yes, it is safe to take smellaid and Zenidine together.

Can I take Zofran and Zenidine together?

Yes, it is safe to take Zofran and Zenidine together.

Can I take Allegra and Zenidine together?

Yes, it is safe to take Allegra and Zenidine together.

Can I take a multivitamin and Zenidine together?

Yes, it is safe to take a multivitamin and Zenidine together.

Can I take Tagamet and Zenidine together?

No, it is not recommended to take Tagamet and Zenidine together as they both contain similar active ingredients and can lead to an overdose.

Can Zenidine cause stomach pain?

Yes, Zenidine can cause stomach pain in some people. If you experience stomach pain while taking Zenidine, it is important to contact your doctor.

Can I take ibuprofen and Zenidine at the same time?

Yes, it is safe to take ibuprofen and Zenidine at the same time.

Can I take aspirin and Zenidine at the same time?

Yes, it is safe to take aspirin and Zenidine at the same time.

Can Zenidine cause headaches?

Yes, Zenidine can cause headaches in some people. If you experience headaches while taking Zenidine, it is important to contact your doctor.

Can I take Benadryl and Zenidine together?

Yes, it is safe to take Benadryl and Zenidine together.

Can I take Tylenol and Zenidine together?

Yes, it is safe to take Tylenol and Zenidine together.

Can I take Prevacid and Zenidine together?

No, it is not recommended to take Prevacid and Zenidine together as they both contain similar active ingredients and can lead to an overdose.

Can I take Zenidine and Pepcid AC together?

No, it is not recommended to take Zenidine and Pepcid AC together as they both contain similar active ingredients and can lead to an overdose.

Can Zenidine cause dizziness?

Yes, Zenidine can cause dizziness in some people. If you experience dizziness while taking Zenidine, it is important to contact your doctor.