Xelcom
Xelcom Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Xelcom is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Xelcom (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Xelcom is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Xelcom works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Xelcom can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Xelcom is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Xelcom is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Xelcom is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Xelcom should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Xelcom may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Xelcom use, however it can cause serious side effects in certain individuals.Precautions
- Xelcom should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Xelcom may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Xelcom should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Xelcom may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Xelcom alongside any other medications.Food Interactions
Food interactions with Xelcom are not known.Pregnancy Use
Xelcom should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Xelcom is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Xelcom is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Xelcom is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Xelcom should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Xelcom is not known.Half-Life
The half-life of Xelcom is approximately 22 days.Clearance
The clearance of Xelcom is not known.Here you find in details version of Xelcom
Some Frequently Asked Questions About Xelcom
you can give answe only.What is Xelcom?
Xelcom is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Xelcom?
The chemical name of Xelcom is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Xelcom taken?
Xelcom is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Xelcom?
The most common side effects of Xelcom include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Xelcom?
The recommended dose of Xelcom is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Xelcom be used?
Xelcom should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Xelcom?
Xelcom should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Xelcom?
An overdose of Xelcom can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Xelcom is a medical emergency and should be treated as such.
What are the interactions of Xelcom with other medications?
Xelcom may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Xelcom?
The shelf life of Xelcom is three years from the date of manufacture.
Is Xelcom used for pregnant women?
The safety of Xelcom for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Xelcom.
Is there any generic version of Xelcom available?
No, there is not a generic version of Xelcom available.
How long does it take for Xelcom to take effect?
The effect of Xelcom is usually immediate.
How often can Xelcom be taken?
Xelcom should not be taken more than once every six hours.
What are some alternatives to Xelcom?
Alternatives to Xelcom include adenosine, aminophylline, and calcium channel blockers.
Can Xelcom be taken with other medications?
Yes, it is possible to take Xelcom with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Xelcom.
Can I take Xelcom if I am breastfeeding?
No, Xelcom is not recommended for women who are breastfeeding.
Is Xelcom safe for children?
No, Xelcom should not be given to children.
Can Xelcom be used for pulmonary disorders?
No, Xelcom is not recommended for the treatment of pulmonary disorders.
Does Xelcom interfere with other medications?
Yes, Xelcom can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Xelcom be administered orally?
No, Xelcom should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Xelcom?
Xelcom should not be taken more than once every six hours.
What should I do if I miss a dose of Xelcom?
If you miss a dose of Xelcom, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Xelcom?
Common symptoms of an allergic reaction to Xelcom include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Xelcom with food?
Yes, it is okay to take Xelcom with food.
Can I take Xelcom if I’m on dialysis?
Xelcom should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Xelcom?
The cost of Xelcom will vary depending on the dosage and the pharmacy where it is purchased.
Is Xelcom habit-forming?
No, Xelcom is not known to be habit-forming.
Can Xelcom be used to treat arrhythmias?
Yes, Xelcom is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Xelcom?
The most common side effects of Xelcom include dizziness, nausea, and sweating.
Does Xelcom interact with other medications?
Yes, Xelcom can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Xelcom a controlled substance?
No, Xelcom is not a controlled substance.
Should I take Xelcom with food?
Yes, it is okay to take Xelcom with food.
Can I take Xelcom if I’m pregnant?
No, the safety of Xelcom for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Xelcom.
Can Xelcom be given intramuscularly?
Yes, Xelcom can be administered intramuscularly.
How should Xelcom be stored?
Xelcom should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Xelcom?
The recommended dose of Xelcom is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Xelcom cause drowsiness?
Yes, Xelcom can cause drowsiness.
Can I take Xelcom if I’m taking other medications?
Yes, it is possible to take Xelcom with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Xelcom.
Is Xelcom safe for the elderly?
Yes, Xelcom is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Xelcom be used to treat atrial fibrillation?
Yes, Xelcom can be used to treat atrial fibrillation.
Can Xelcom be used to treat ventricular tachycardia?
Yes, Xelcom can be used to treat ventricular tachycardia.