Violen
Violen Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Violen is a brand name. Its generic name is Gentian Violet.
Violen
Gentian violet (also known as crystal violet, Eosin Methylene Blue, or methyl violet 10B) is a blue-violet dye used in a variety of medical applications since its introduction in the late 19th century. It is composed of the thiazine dye methylene blue and the triphenylmethane dye eosin. It is a potent antiseptic and has a variety of uses, including skin infections, bacterial endocarditis, and fungal infections.
Uses for Violen
Gentian violet is used as an antiseptic to prevent and treat infection. It is also used as a topical treatment for fungal and bacterial infections of the skin and mucous membranes such as thrush, ringworm, tinea versicolor, and impetigo. It can be applied topically to the affected skin area or administered orally.
Mechanism of Action
Gentian violet works by disrupting the walls of bacteria and fungi, resulting in their destruction. It also prevents bacteria and fungi from reproducing.
How Long Does It Take to Work?
Gentian violet typically begins to work within 1 to 2 days of application. Visible improvement may be seen after 1 week of treatment.
Absorption
Gentian violet is not known to be absorbed after topical application to the skin. However, when taken orally, gentian violet can be absorbed and redistributed throughout the body.
Route of Elimination
Gentian violet is primarily excreted in the urine and feces.
Dosage
The usual recommended dosage of gentian violet for adults is 2 to 4 drops applied to the affected skin area three to four times per day, or orally 2 to 4 times per day. For children, the usual recommended dosage is 3 to 4 drops applied to the affected area three to four times per day, or orally 2 to 4 times per day. For further information, refer to the manufacturer's label.
Administration
Gentian violet is usually applied topically or taken orally. It is available as a solution or as tablets. For topical application, use a cotton swab to apply the solution directly to the affected area. For oral administration, dissolve the tablets in water and drink the solution.
Side Effects
Gentian violet is generally well tolerated, although some people may experience skin irritation or discoloration. Other potential side effects include dryness, itching, or burning of the skin. Serious side effects are rare.
Toxicity
Gentian violet is generally non-toxic when applied topically or taken orally as directed. However, overdoses or improper use may lead to toxicity. Symptoms of toxicity include nausea, vomiting, headache, chest pain, and dizziness.
Precautions
Gentian violet should not be used on open wounds or broken skin. It should not be taken orally by pregnant women, or by those who have any allergy to thiazines or triphenylmethanes. It should also not be used on people with a history of kidney or liver diseases or on those taking certain medications such as antibiotics, antifungals, or beta blockers.
Interaction
Gentian violet may interact with other medications, such as antibiotics, antifungals, and beta blockers. It should also not be used in combination with other topical antifungals, as this may increase the risk of skin irritation.
Disease Interaction
Gentian violet should be used with caution in patients with kidney or liver disease, as it may aggravate the condition. It should also not be used in patients with AIDS, as it may increase the risk of skin irritation.
Drug Interaction
Gentian violet may interact with medications such as antibiotics, antifungals, and beta blockers. It should not be taken in combination with other topical antifungals, as this may increase the risk of skin irritation.
Food Interactions
Gentian violet is not known to interact with food. However, it should be taken with food to reduce the potential for nausea and vomiting.
Pregnancy Use
Gentian violet is not recommended for use during pregnancy, as its safety has not been established. Women who are pregnant or breastfeeding should consult their healthcare provider before using gentian violet.
Lactation Use
Gentian violet is not recommended for use during breastfeeding, as its safety has not been established. Women who are breastfeeding should consult their healthcare provider before using gentian violet.
Acute Overdose
An acute overdose of gentian violet may lead to nausea, vomiting, headache, chest pain, and dizziness.
Contraindication
Gentian violet should not be used on people with a history of kidney or liver diseases or on those taking certain medications such as antibiotics, antifungals, or beta blockers. It should also not be used by pregnant or breastfeeding women.
Use Direction
For topical application, use a cotton swab to apply 2 to 4 drops of gentian violet solution to the affected area three to four times per day. For oral administration, dissolve the tablets in water and drink the solution.
Storage Condition
Gentian violet should be stored in a cool, dry place and away from direct sunlight.
Volume of Distribution
Gentian violet has a volume of distribution of ∼1.2 L/kg.
Half Life
The half-life of gentian violet is ∼8 hours.
Clearance
Gentian violet has a clearance of ∼200 mL/min.
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