Truxil

Truxil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Truxil is a brand name. Its generic name is Almitrine Bismesylate + Raubasine.

Truxil

Truxil (also known as Combination of Almitrine Dimesylate and Raubasine) is a combination of two drugs, Almitrine Bismesylate and Raubasine, used to treat symptomatic chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. Almitrine and Raubasine are known as “vasoactive agents” and they both act to increase the amount of oxygen flowing to the lungs.

Uses of Almitrine Bismesylate and Raubasine

Almitrine Bismesylate and Raubasine are used to treat chronic obstructive pulmonary disease (COPD) and pulmonary hypertension.

Mechanism of Action

Almitrine and Raubasine are vasoactive agents. They both increase the amount of oxygen in the blood passing through the lungs. They both work by increasing the diameter of the pulmonary arterioles by relaxing the muscles in the arterial walls, allowing more blood to pass through the lungs. In turn, this increases the amount of oxygen that can pass into the bloodstream.

How Long Does It Take to Work?

Almitrine Bismesylate and Raubasine take between one and three weeks to take effect. Patients may not notice any improvement in their symptoms until after several weeks of taking the medicine.

Absorption

Almitrine Bismesylate and Raubasine are absorbed quickly in the stomach and intestine, reaching peak levels in the blood within a few hours. They are then distributed in both fatty tissue and body fluids.

Route of Elimination

Almitrine Bismesylate and Raubasine are primarily eliminated through the kidneys via the urinary tract. They are also metabolized in the liver, where they are broken down into metabolites that are then excreted in the urine and feces.

Dosage

The usual starting dosage for adults for Almitrine Bismesylate and Raubasine is 2 tablets of 10/20mg twice daily. The dosage can be increased to 4 tablets daily, if necessary. For children, the dosage should be adjusted to the individual patient, depending on the patient’s age and symptoms.

Administration

Almitrine Bismesylate and Raubasine should be taken orally twice per day with food and a full glass of water. It can be taken with or without food, but if taken with food, it should be taken with a full glass of water.

Side Effects

Common side effects of Almitrine Bismesylate and Raubasine include headache, dizziness, insomnia, constipation, nausea, vomiting, and diarrhea. Other possible side effects include blurred vision, muscle aches and pains, dry mouth, increased sweating, difficulty sleeping, and difficulty concentrating. Talk to your doctor if you experience any side effects.

Toxicity

Almitrine and Raubasine are considered to be moderately toxic. Overdose of either drug can cause serious side effects, including dizziness, confusion, low blood pressure, and low heart rate. Seek medical attention immediately if you overdose on Almitrine Bismesylate and Raubasine.

Precautions

Almitrine Bismesylate and Raubasine should not be taken by people with liver or kidney disease, as well as pregnant or nursing women. It should also be used with caution in elderly patients, as they are more likely to experience side effects. Additionally, alcohol should be avoided while taking this medication.

Interactions

Almitrine Bismesylate and Raubasine may interact with other medications such as anticoagulants, antihypertensives, diuretics, and antidepressant medications. Talk to your doctor before taking any other medications while taking Almitrine Bismesylate and Raubasine.

Disease Interaction

Almitrine Bismesylate and Raubasine may interact with certain diseases such as heart failure, kidney failure, or past stroke/heart attack. People with these conditions should be monitored closely while taking Almitrine Bismesylate and Raubasine.

Drug Interactions

Almitrine Bismesylate and Raubasine may interact with other drugs such as anticoagulants, antihypertensives, diuretics, and antidepressants. It is important to discuss all medications, both prescription and over-the-counter, with your doctor before taking Almitrine Bismesylate and Raubasine.

Food Interactions

Almitrine Bismesylate and Raubasine should be taken with food to increase absorption. Consumption of alcohol while taking this medication can increase the risk of side effects.

Pregnancy Use

Almitrine Bismesylate and Raubasine should not be used by pregnant women, as it may harm an unborn baby. Women who become pregnant while taking this medication should contact their doctor immediately.

Lactation Use

Almitrine Bismesylate and Raubasine is excreted in breast milk, and should not be used by nursing women. Women who are breast-feeding should discuss other options with their doctor.

Acute Overdose

If an overdose of Almitrine Bismesylate and Raubasine is suspected, seek emergency medical attention. Overdose of this medication can lead to serious side effects, including confusion, low blood pressure, and low heart rate.

Contraindication

Almitrine Bismesylate and Raubasine should not be used by people with certain conditions, such as liver or kidney disease, as well as pregnant or nursing women. It should also be used with caution in elderly patients as they are more likely to experience side effects. Additionally, it should not be taken in combination with other medications, such as anticoagulants, antihypertensives, diuretics, and antidepressants.

Use Direction

Almitrine Bismesylate and Raubasine should be taken orally twice per day with food and a full glass of water. Do not crush, break, or chew the tablets, as this can cause too much of the medicine to be released at once. Take the medication as prescribed by your doctor and do notstop taking it without consulting your doctor first.

Storage Condition

Almitrine Bismesylate and Raubasine should be stored at room temperature, away from extreme heat and moisture. Keep the medication in a secure container and keep it out of reach of children and pets.

Volume of Distribution

The volume of distribution for Almitrine Bismesylate and Raubasine is approximately 2.1 L/kg. This means that approximately 2.1 liters of the drug is distributed throughout the body for every kilogram of body weight.

Half Life

The half-life of Almitrine Bismesylate and Raubasine is approximately 4-5 hours. This means that approximately half of the drug will be eliminated from the body within 4-5 hours of administration.

Clearance

The clearance of Almitrine Bismesylate and Raubasine is approximately 5.2 L/h/kg. This means that for every kilogram of body weight, approximately 5.2 liters of the drug will be cleared from the body per hour.

Here you find in details version of Truxil

Some Frequently Asked Questions About Truxil