Trolen
Trolen Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Trolen is a brand name. Its generic name is Dantrolene.
Trolen
Trolen is a muscle relaxant medication typically used to treat muscle spasticity caused by neurological conditions such as multiple sclerosis, cerebral palsy, and stroke. It is also used to treat malignant hyperthermia - a life-threatening reaction to certain medications and anesthetic agents. Trolen works by blocking the release of calcium from the sarcoplasmic reticulum in muscle cells.
Uses For
The primary use of dantrolene is in the treatment of muscle spasticity caused by neurological conditions such as multiple sclerosis, cerebral palsy, and stroke. It can also be used in the treatment of malignant hyperthermia, a life-threatening reaction to certain medications and anesthetic agents.
Mechanism of Action
Trolen works by blocking the release of calcium from the sarcoplasmic reticulum in muscle cells. These calcium ions play an important role in muscle contraction and so, by blocking their release, dantrolene helps to relax the muscle. It also helps to reduce excess heat production, which prevents malignant hyperthermia.
How Long Does It Take To Work?
Trolen typically begins to work within 2 to 4 hours after administration. The extent of muscle relaxation and the duration of effects may vary depending on the individual and their condition.
Absorption
Trolen is absorbed well from the intestines into the bloodstream. It has an elimination half-life of 6 - 7 hours.
Route of Elimination
Trolen is eliminated through the kidneys. The drug is excreted in the urine and feces.
Dosage & Administration
The dosage of dantrolene will vary based on the individual and their health condition. The usual adult dosage is 25 to 100 mg four times a day. This dosage may be adjusted based on the patient's response and side effects. Trolen should be taken with food or milk to reduce stomach upset. This medication should not be taken more than four times a day. Trolen is available in a 25 mg and 100 mg tablet.
Side Effects
The most common side effects of dantrolene include dizziness, drowsiness, weakness, fatigue, nausea, vomiting, diarrhea, constipation, abdominal pain, and headache. Other less common side effects can include dry mouth, blurred vision, skin rash, and confusion. These side effects typically subside over time as the body adjusts to the medication.
Toxicity
Trolen is generally safe and well-tolerated when taken as directed. Overdoses of dantrolene may cause hypotension, bradycardia, arrhythmias, and respiratory depression. As with any medication, it is important to take it as prescribed and never take more than the recommended dose.
Precaution
Before taking dantrolene, tell your doctor if you have liver or kidney disease, heart disease, diabetes, or a history of mental illness. You should also not take dantrolene if you are pregnant or breastfeeding. Tell your doctor about all the medications you are taking, including vitamins and supplements.
Interactions
Trolen may interact with certain medications, anesthetics agents, vitamins and supplements, and alcohol. If you are taking any of these, talk to your doctor before taking dantrolene. Medications that may interact with dantrolene include anesthetics, benzodiazepines, narcotic pain relievers, and statins.
Disease Interaction
Trolen may interact with certain health conditions, such as heart disease, liver disease, kidney disease, or a history of mental illness. Talk to your doctor before taking dantrolene if you have any of these conditions.
Drug Interactions
Trolen may interact with certain medications, anesthetics agents, vitamins and supplements, and alcohol. If you are taking any of these, talk to your doctor before taking dantrolene. Medications that may interact with dantrolene include anesthetics, benzodiazepines, narcotic pain relievers, and statins.
Food Interactions
Trolen may interact with certain foods. It is important to tell your doctor about any herbal remedies, vitamins and supplements, and other over-the-counter and prescription medications you are taking. Do not take dantrolene with grapefruit juice as this can increase the levels of the drug in your body.
Pregnancy Use
Trolen is not recommended for use during pregnancy. It is not known whether this drug passes into breast milk, so it should not be used by women who are breastfeeding.
Lactation Use
Trolen is not recommended for use by women who are breastfeeding. It is not known whether this drug passes into breast milk, so it should not be taken by mothers who are breastfeeding.
Acute Overdose
An overdose of dantrolene can be fatal. The symptoms of an overdose may include dizziness, loss of coordination, weakness, and fainting. If you or someone else has overdosed, seek medical help immediately.
Contraindication
Trolen is contraindicated in patients with known sensitivity to the drug and in patients with liver or kidney disease, heart disease, diabetes, or a history of mental illness. It is also not recommended for pregnant or breastfeeding women.
Use Directions
Trolen is taken orally, usually four times a day. The dosage will vary depending on the individual and their condition. It should be taken with food or milk to reduce stomach upset. Do not take more than four doses a day.
Storage Condition
Store dantrolene at room temperature away from moisture and heat. Do not store in the bathroom. Do not freeze. Keep out of the reach of children.
Volume of Distribution
Trolen is distributed throughout the body in small amounts. It is found in higher concentrations in muscle tissue, liver, and plasma.
Half Life
The elimination half-life of dantrolene is 6 - 7 hours. It is eliminated from the body via the kidneys.
Clearance
Trolen is cleared from the body by the kidneys. The clearance rate is affected by the concentration of the drug in the body.
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