Trec

Trec Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Trec is a brand name. Its generic name is Itraconazole.

Trec

Trec, marketed under the brand names Sporanox and Onmel, is an antifungal prescription medication used to treat a variety of fungal infections. Trec belongs to a class of medications called azole antifungals, which work by blocking the growth of certain types of fungi.

Uses For

Trec is used to treat a variety of fungal infections, including, but not limited to, aspergillosis, blastomycosis, histoplasmosis, and cryptococcosis. It is also used to treat fungal nail infections.

Mechanism of Action

Trec works by interfering with the fungal cell membrane, preventing the absorption of essential nutrients. It slows the growth and spread of the fungus, allowing the body's immune system to fight the infection.

How Long Does It Take to Work?

Trec begins to work immediately after being taken, although it may take several weeks for symptoms to improve. It is important to complete the entire course of treatment to ensure that the infection is completely eliminated.

Absorption

Trec is well absorbed and highly soluble in water. It is typically absorbed within 30 minutes to 1 hour of taking the medication.

Route of Elimination

Trec is metabolized by the liver and then excreted in the urine and feces.

Dosage

The recommended dosage of itraconazole depends on the patient's age and the type and severity of the condition being treated. The usual adult dosage is 200 mg, taken once or twice daily. In some cases, doses may be increased up to 400 mg per day. The usual dosage in children 12 and older is 200 mg per day.

Administration

Trec should be taken with food. The capsules should be swallowed whole, not chewed or opened. Liquid formulations should be taken with food or immediately after meals.

Side Effect

Common side effects of itraconazole include nausea, vomiting, abdominal pain, headache, dizziness, rash, and insomnia. If any of these side effects persist or worsen, patients should seek medical attention.

Toxicity

Trec can cause serious adverse reactions when taken in large doses. In rare cases, it can cause liver failure or abnormal liver function tests. Patients who experience any signs of liver damage should seek medical attention immediately.

Precautions

Trec should be used with caution in individuals with liver or kidney disease, heart disease, or a history of drug-induced liver injury. It should not be used in pregnant women or nursing mothers.

Interactions

Trec should not be used simultaneously with certain other medications, including some anticoagulants, certain antiarrhythmics, and certain antibiotics. Patients should discuss all the medications they take with their healthcare provider.

Disease Interactions

Trec should not be used in patients with certain medical conditions, including liver disease and congestive heart failure. Patients with certain diseases may be at higher risk for adverse reactions to the medication.

Drug Interactions

Trec may interact with other medications, affecting their effectiveness or causing adverse reactions. Patients should discuss all medications they take with their healthcare provider.

Food Interactions

Trec may interact with certain medications and foods. Foods that contain calcium, magnesium, iron, or aluminum may reduce the absorption of itraconazole, and should be avoided within 3 hours before or after taking it. Foods that contain high amounts of fat, sugar, or starch should also be avoided.

Pregnancy Use

Trec should not be used during pregnancy unless it is clearly necessary. Women who are pregnant or planning to become pregnant should discuss the use of this medication with their healthcare provider.

Lactation Use

Trec should not be used during lactation unless it is clearly necessary. Women who are breastfeeding should discuss the use of this medication with their healthcare provider.

Acute Overdose

An acute overdose of itraconazole can cause serious symptoms, such as nausea, vomiting, abdominal pain, dizziness, and seizures. If an overdose is suspected, immediate medical treatment should be sought.

Contraindication

Trec should not be used in patients with known hypersensitivity to it or other azole antifungal medications.

Use Direction

Trec should be taken exactly as directed by a healthcare provider. The dosage and duration of treatment should not be altered without consulting a doctor.

Storage Condition

Trec should be stored at room temperature away from light and moisture. It should be kept out of the reach of children.

Volume of Distribution

Trec has a volume of distribution of 16.1 liters.

Half Life

Trec has an elimination half-life of 36 hours.

Clearance

Trec has an estimated total clearance of 146 ml/min.

Here you find in details version of Trec

Some Frequently Asked Questions About Trec

What is Trec?

Trec is an antifungal medication that is used to treat a wide variety of fungal infections. It is available in oral form as well as intravenous (IV) form.

What type of infections does itraconazole treat?

Trec is used to treat a variety of fungal infections, including infections of the lungs, mouth, throat, and sinuses; nail and skin infections; and invasive fungal infections.

What is the usual dosage of itraconazole?

Trec is available in oral form and intravenous form. The usual adult dosage is 200 mg twice daily. The dosage for children may be lower, depending on the type of infection.

Who should not take itraconazole?

Trec should not be taken by people who are allergic to it or to any of its ingredients. It should also not be taken by people with certain medical conditions, including heart failure and certain types of heart rhythm disorders.

What are the common side effects of itraconazole?

The most commonly reported side effects of itraconazole are nausea, vomiting, abdominal pain, and headache. Other rare but serious side effects include liver toxicity, allergic reactions, and increased risk of bleeding.

What precautions should be taken when taking itraconazole?

Trec should not be taken with certain medications, as they can interact with each other and cause dangerous side effects. People taking itraconazole should also not take grapefruit juice or products containing grapefruit juice, as it may interact with the medication. Talk to your doctor before taking any other medications or supplements, even those available over-the-counter.

What should I do if I miss a dose of itraconazole?

If you miss a dose of itraconazole, take it as soon as you remember, unless it is almost time for the next dose. If it is almost time for the next dose, skip the missed dose and take the next dose as usual.

Can pregnant women take itraconazole?

It is not recommended that pregnant women take itraconazole, as it can be harmful to the unborn baby. If you are pregnant or trying to become pregnant, talk to your doctor before taking itraconazole.

Are there any interactions with itraconazole and other medications?

Yes, there are several medications that can interact with itraconazole, including some antibiotics, anticonvulsants, antidepressants, and other antifungals. Make sure to tell your doctor about all the medications you are taking or plan to take so that your doctor can adjust your dose to avoid interactions.

What should I do if I experience any adverse reactions while taking itraconazole?

If you experience any adverse reactions while taking itraconazole, such as rash, headache, dizziness, or nausea, contact your doctor immediately. They may need to adjust your dose, stop treatment, or give you additional medication to counteract the reaction.

How long does it take for itraconazole to take effect?

The amount of time it takes for itraconazole to take effect depends on the type of infection being treated and the severity of the infection. It typically takes several days to three weeks for itraconazole to start working.

Can I take itraconazole with alcohol?

No, you should not drink alcohol while taking itraconazole, as it could increase the risk of liver damage. Talk to your doctor if you have any questions about alcohol and itraconazole.

Can I take itraconazole if I have kidney disease?

Trec should be used with caution in patients with kidney disease and dosage adjustments may be necessary. Talk to your doctor if you have any questions or concerns.

Does itraconazole make you drowsy?

Trec can cause drowsiness in some people. Do not drive or operate heavy machinery until you know how it affects you.

Can I take itraconazole while breastfeeding?

It is not recommended to take itraconazole while breastfeeding, as it may pass through breast milk and harm the baby. Talk to your doctor about the risks and benefits of taking itraconazole while breastfeeding.

Is itraconazole available in generic form?

Yes, itraconazole is available in generic form, as well as brand name form. Talk to your doctor or pharmacist about which form is best for your condition.

What other medications should not be taken while taking itraconazole?

Trec should not be taken with certain medications, as they can interact with each other and cause dangerous side effects. Some of the medications that should not be taken with itraconazole include anticonvulsants, certain antibiotics, warfarin, and medications that are metabolized by the liver.

When should I expect to see results while taking itraconazole?

It typically takes several days to three weeks for itraconazole to start working. You may not notice any improvement until then. Talk to your doctor if you don't see any noticeable improvement after taking itraconazole for an extended period of time.

Does itraconazole cause dependency?

Trec does not typically cause dependence and can be safely used over the long-term. Talk to your doctor if you have any questions concerning the duration of treatment.

Can children take itraconazole?

Yes, children can take itraconazole but the dosage may be lower than what is usually prescribed for adults. Make sure to talk to your doctor before giving any medication to a child.

What foods should I avoid while taking itraconazole?

Grapefruit juice and products containing grapefruit should be avoided while taking itraconazole, as it can interact with the medication. Talk to your doctor or pharmacist about other foods or supplements that may interact with the medication.

What should I do if I overdose on itraconazole?

If you suspect or know you've taken too much itraconazole, seek medical help immediately. You should also bring the medications or supplement you took with you to the hospital, as it may help the doctor in treating the overdose.

Can I take itraconazole while taking birth control?

It is generally safe to take itraconazole while taking birth control. However, women taking birth control should use a backup form of contraception while taking itraconazole, as it may decrease the efficacy of some forms of contraception.

Is itraconazole available over-the-counter?

No, itraconazole is not available over-the-counter. Talk to your doctor or pharmacist if you have any questions about obtaining itraconazole.

How long should I take itraconazole?

The length of time you should take itraconazole depends on the type and severity of the infection you're treating. Talk to your doctor about how long you should be taking itraconazole.

Can I take itraconazole with fluconazole?

No, you should not take itraconazole and fluconazole together, as they can interact with each other and cause dangerous side effects. Talk to your doctor before taking any other medications or supplements, even those available over-the-counter.

Are there any other forms of itraconazole available?

Trec is available in oral form as well as intravenous form. It is also available in brand name and generic forms. Talk to your doctor or pharmacist about which form is best for your condition.

What is the maximum daily dose of itraconazole?

The maximum daily dose of itraconazole is 400 mg. Talk to your doctor if you think your symptoms are not improving with the usual adult dosage of 200 mg twice daily.

Can I take itraconazole with clopidogrel?

No, you should not take itraconazole with clopidogrel, as it may reduce the effectiveness of the medication. Talk to your doctor about other medications that should not be taken with itraconazole.

Does itraconazole interact with vitamins or supplements?

Yes, itraconazole can interact with certain vitamins and supplements. It is important to talk to your doctor or pharmacist about all the medications you are taking before taking any vitamins or supplements.

What are the long-term effects of taking itraconazole?

The long-term effects of itraconazole depend on the reason for taking it. Common long-term side effects include headache, nausea, vomiting, abdominal pain, and liver toxicity. Talk to your doctor about the possible long-term effects of taking itraconazole.

Can people with diabetes take itraconazole?

Yes, people with diabetes can take itraconazole, but it may interact with certain medications they are taking. Talk to your doctor before taking itraconazole if you have diabetes.

What is the best way to store itraconazole?

Trec should be stored at room temperature, away from heat and moisture. Do not store it in the bathroom or near a source of heat, such as a stove. Keep it away from children and pets.

How long does itraconazole stay in the body?

The half-life of itraconazole is approximately 24 hours, so it typically stays in the body for a few days. Your doctor may be able to give you more specific information about the length of time it will stay in your body.

What should I do if I forget to take my itraconazole dose?

If you forget to take your itraconazole dose, take it as soon as you remember, unless it is almost time for the next dose. If it is almost time for the next dose, skip the missed dose and take the next dose as usual.

Can I stop taking itraconazole without consulting my doctor?

It is not recommended to stop taking itraconazole without consulting your doctor. Stopping treatment prematurely may lead to a relapse of the infection and could make it more difficult to treat. Talk to your doctor about the risks of stopping itraconazole before you decide to do so.

What should I tell my doctor before taking itraconazole?

You should always tell your doctor about any medications or supplements you are using, including prescription and non-prescription drugs as well as vitamins, herbs, and supplements. This will help your doctor adjust your dose if needed to avoid any dangerous or unwanted interactions.

Should I take itraconazole on an empty stomach?

It is usually recommended to take itraconazole on an empty stomach, but talk to your doctor if you experience any stomach discomfort. You may be able to take it with food or milk if it causes any gastrointestinal side effects.

Can itraconazole be taken with food?

It is usually recommended to take itraconazole on an empty stomach, but talk to your doctor if you experience any stomach discomfort. You may be able to take it with food or milk if it causes any gastrointestinal side effects.

How long can I stay on itraconazole?

The duration of treatment with itraconazole depends on the type and severity of the infection being treated. Talk to your doctor about how