Trado

Trado Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Trado is a brand name. Its generic name is Tramadol.

Trado

Trado, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Trado also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Trado is available in both immediate-release and extended-release forms.

Uses For Trado

Trado is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Trado is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Trado works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Trado also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Trado typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Trado is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Trado is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Trado depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Trado can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Trado include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Trado is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Trado should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Trado should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Trado may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Trado may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Trado can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Trado should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Trado is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Trado should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Trado is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Trado should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Trado should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Trado has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Trado has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Trado has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Trado

Some Frequently Asked Questions About Trado

What is Trado?

Trado is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Trado?

Trado's generic name is Ultram.

What is the mechanism of action of Trado?

Trado works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Trado a controlled substance?

Yes, Trado is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Trado work?

Trado works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Trado be taken?

Trado should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Trado?

The most common side effects of Trado include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Trado together?

Yes, acetaminophen and Trado can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Trado?

Signs of an overdose of Trado include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Trado be used for back pain?

Yes, Trado is often prescribed for the treatment of back pain.

Is Trado addictive?

Yes, Trado can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Trado?

If you forget to take a dose of Trado, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Trado be taken with alcohol?

No, Trado should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Trado?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Trado safe for long-term use?

Trado is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Trado be taken during pregnancy?

Trado should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Trado if I have a history of drug abuse?

No, Trado should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Trado show up on a drug test?

Yes, Trado may show up on a drug test, though the results may vary depending on the type of test.

Can I take Trado if I have liver or kidney disease?

Trado should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Trado with anti-anxiety medications?

No, Trado should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Trado?

If you experience any side effects from Trado, contact your doctor as soon as possible.

What other pain relievers can be taken with Trado?

Trado can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Trado?

The maximum daily dose of Trado is 400 milligrams per day for adults.

Does Trado cause constipation?

Yes, constipation is a common side effect of Trado.

Can I take Trado and Trado Plus together?

No, Trado and Trado Plus should not be taken together as it may increase the risk of adverse reactions.

Can Trado be taken for headaches?

Yes, Trado is often prescribed for the treatment of headaches.

Is Trado ever prescribed for arthritis?

Yes, Trado is sometimes prescribed for the treatment of arthritis.

Does Trado interact with other medications?

Yes, Trado may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Trado.

Can Trado be taken for menstrual cramps?

Yes, Trado can be prescribed for the treatment of menstrual cramps.

Can Trado be crushed for easier swallowing?

No, Trado should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Trado be used to treat?

Trado may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Trado while breastfeeding?

No, Trado should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Trado be taken with anti-depressants?

Yes, Trado can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Trado be taken with vitamins or supplements?

Yes, Trado can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Trado.

Can Trado be taken with antihistamines?

Yes, Trado can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Trado with other pain relievers?

No, Trado should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Trado metabolized by the liver?

Yes, Trado is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Trado.

How long will Trado stay in my system?

Trado can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Trado?

If you miss a dose of Trado, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Trado while taking other medications?

Yes, Trado can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Trado.

Does Trado affect blood pressure?

Yes, Trado may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Trado HCL?

Trado HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Trado?

The withdrawal symptoms of Trado may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Trado cause hallucinations?

Yes, Trado can cause hallucinations, especially at higher doses.

Is Trado the same as Vicodin?

No, Trado and Vicodin are different medications. Trado is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Trado be taken with other medications for pain?

Yes, Trado can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Trado.