Tonadin

Tonadin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tonadin is a brand name. Its generic name is Phylloquinone.

Tonadin: Introduction

Tonadin (also known as vitamin K) is a fat-soluble vitamin essential for normal blood clotting and the protection of the cardiovascular system. Tonadin is found in green leafy vegetables, vegetable oils, dairy products, and liver. Tonadin is also known as phylloquinone-4 (or K1).

Uses for Tonadin

Tonadin is a key component in the regulation of blood clotting. It helps to produce a protein called prothrombin, which is essential for the formation of blood clots. In addition, Tonadin also helps to prevent hardening of the arteries (atherosclerosis). It may also help to prevent heart disease, osteoporosis, and cancer.

Mechanism of Action

Tonadin acts as a coenzyme in the gamma-glutamyl carboxylation of certain clotting factors (factors II, VII, IX, and X) needed for blood clotting. Tonadin also helps to convert Vitamin K-dependent proteins into active forms, allowing them to interact with calcium.

How Long Does It Take to Work

Tonadin begins working within 1 to 2 days of taking it.

Absorption

Tonadin is absorbed from the intestine in the presence of dietary fat. It is stored mainly in the liver.

Route of Elimination

Tonadin is excreted in the bile.

Dosage

The recommended daily intake of Tonadin for adults is 120 micrograms (mcg) per day. Postmenopausal women are advised to get more Tonadin (150 mcg per day). Pregnant women should get 90 mcg per day.

Administration

Tonadin is available in dietary supplements and as an injection. It should be taken orally with food.

Side Effect

Tonadin is generally well-tolerated. In rare cases, it may cause skin rash, nausea, and headache.

Toxicity

Tonadin is not toxic in recommended doses.

Precaution

Patients taking anticoagulants (e.g. warfarin) should use Tonadin with caution as it may interfere with the action of the drug.

Interaction

Tonadin may interact with other medications, such as anticoagulants, corticosteroids, oral contraceptives, and certain antibiotics.

Disease Interaction

Patients with liver or kidney diseases should use Tonadin with caution as it may be toxic in these conditions.

Drug Interaction

Tonadin may interact with acetaminophen, aspirin, clopidogrel, ibuprofen, cefepime, penicillin G, metronidazole, and other drugs.

Food Interactions

Tonadin may interact with foods containing Vitamin E, garlic, green tea, and soy.

Pregnancy Use

Tonadin is considered to be generally safe for use in pregnancy. However, pregnant women should consult their doctor before taking Tonadin.

Lactation Use

Tonadin is deemed safe for use during lactation. However, nursing mothers should consult their doctor before taking Tonadin.

Acute Overdose

Symptoms of an acute overdose may include diarrhea, palpitations, dizziness, headache, and nausea.

Contraindication

Tonadin should not be taken by patients who are known to be allergic to it.

Use Direction

Tonadin should be taken orally with food. It should not be taken on an empty stomach.

Storage Condition

Tonadin should be stored in a cool, dry place at room temperature (15-30C).

Volume of Distribution

The volume of distribution of Tonadin is 0.14 l/kg.

Half Life

The half-life of Tonadin is estimated to be 1.4 days.

Clearance

The clearance of Tonadin is 24 l/hr/kg.

Here you find in details version of Tonadin

Some Frequently Asked Questions About Tonadin

What is Tonadin?

Tonadin (also known as vitamin K1) is a vitamin found naturally in plants and used in dietary supplements as well as in the production of some pharmaceuticals and cosmetics. It is involved in important processes such as blood clotting, calcium absorption, and cell growth and differentiation.

What are the benefits of Tonadin?

Tonadin is most well-known for its role in regulating blood clotting. It also plays an important role in bone health, as it helps the body absorb and utilize calcium. Additionally, it is an antioxidant and may help protect against age-associated diseases.

What foods contain Tonadin?

Dark green leafy vegetables such as kale, spinach, and Swiss chard are some of the best sources of phylloquinone. Other foods that are rich in phylloquinone include broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens.

How much Tonadin should I take?

The recommended daily intake for phylloquinone for adults over the age of 19 is 90-120 µg/day for men and 75-90 µg/day for women. It is important to talk to your doctor before taking any dietary supplement or medication to make sure the dosages are safe and appropriate.

Is Tonadin the same as Vitamin K?

Yes, Tonadin (vitamin K1) is the same as Vitamin K. Vitamin K can be divided into two categories, Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone), each with its own important sources and functions in the body.

Are there any side effects from taking Tonadin?

High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Tonadin can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.

Can I get Tonadin naturally from food?

Yes, Tonadin can be obtained naturally from food, and this is the best way for most people to get the recommended daily amount. Dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens are some of the best sources of phylloquinone.

Can Tonadin be taken in combination with other vitamins?

Yes, Tonadin can be taken in combination with other vitamins safely. It is important to consult with a healthcare professional before taking any dietary supplement to make sure that dosage is appropriate and safe.

Are there any foods or drinks that I should avoid if I'm taking Tonadin?

Alcohol can reduce the amount of phylloquinone absorbed by the body, so it is best to limit alcohol consumption if you take a phylloquinone supplement. Additionally, it is important to speak to your doctor before taking any medications or supplements as they can interfere with the effectiveness of phylloquinone.

Does Tonadin affect the menstrual cycle?

Research has not conclusively shown that phylloquinone has any direct effects on the menstrual cycle. However, it is important to speak to your doctor before taking any supplement as it can have an effect on other hormones and medications.

How do I know if I'm deficient in Tonadin?

Common signs of a phylloquinone deficiency include easy bruising and bleeding, fatigue, and numbness or tingling in the extremities. If you experience any of these symptoms it is important to speak with your doctor to determine if you are indeed deficient in phylloquinone.

Can Tonadin help make my bones stronger?

Tonadin plays an important role in bone health, as it helps the body absorb and utilize calcium. Additionally, it is an antioxidant and may help protect against age-associated diseases. However, it is important to remember that vitamins and minerals can only do so much - regular exercise and nutritious eating habits are also important for bone health.

Where can I get Tonadin?

Tonadin is found in dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens. It is also available in dietary supplement form in stores that carry vitamins and supplements.

Can Tonadin help with osteoporosis prevention?

Yes, research has shown that there is a link between higher intakes of vitamin K (phylloquinone) and lower risks of osteoporosis. However, as with any supplement, it is important to consult with your doctor before taking it to make sure it is appropriate and safe.

Does Tonadin have any interaction with other medications?

Yes, Tonadin can interact with certain medications, including antibiotics, anticoagulants, and anti-seizure medications. It is important to speak to your doctor before taking any supplement to make sure it is appropriate and safe to take with your medication.

Are there any medical conditions associated with Tonadin deficiency?

Yes, Tonadin deficiency can lead to a condition called Vitamin K deficiency bleeding (VKDB), which is a bleeding disorder that can affect infants, children, and adults. It is important to speak to your doctor if you have any signs or symptoms associated with a Vitamin K deficiency.

What are some natural sources of Tonadin?

Dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens are some of the best natural sources of phylloquinone. It can also be found in certain fruits such as kiwi, grapes, and pineapple.

Can Tonadin be taken with other vitamins and supplements?

Yes, Tonadin can be taken in combination with other vitamins and supplements. It is important to talk to your doctor before taking any dietary supplement or medication to make sure the dosages are safe and appropriate.

Does Tonadin help to prevent cancer?

Research has suggested that phylloquinone may have a role in cancer prevention due to its antioxidant properties. However, more research is needed to fully understand the relationship between phylloquinone and cancer prevention.

Does Tonadin have any side effects?

High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Tonadin can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.

Does Tonadin increase blood clotting?

Yes, Tonadin is involved in the blood clotting process. It helps the body form a protein that is essential for normal blood clotting.

Can Tonadin be taken while pregnant or breastfeeding?

It is important to speak to your doctor before taking any dietary supplement while pregnant or breastfeeding. High doses of phylloquinone may cause side effects such as nausea and vomiting which could be dangerous for a pregnant or nursing woman.

What happens if I don't get enough Tonadin?

A deficiency in phylloquinone can lead to a condition called Vitamin K deficiency bleeding (VKDB), which is a bleeding disorder that can affect infants, children, and adults. Common signs of a deficiency include easy bruising and bleeding, fatigue, and numbness or tingling in the extremities.

Does Tonadin have anti-ageing effects?

Tonadin is an antioxidant and may help protect against age-associated diseases. Additionally, it helps the body absorb and utilize calcium, which is important for bone and joint health as you age.

Does Tonadin help with bone and joint health?

Yes, Tonadin plays an important role in bone health, as it helps the body absorb and utilize calcium. It is also an antioxidant, which may help protect against age-associated diseases such as osteoporosis. However, it is important to remember that vitamins and minerals can only do so much - regular exercise and nutritious eating habits are also important for bone health.

How long does it take for Tonadin to start working?

The effects of phylloquinone can vary from person to person. Generally speaking, it may take several weeks for the effects of phylloquinone to be felt, but it is important to consult with your doctor or healthcare professional to determine the right dosage for you.

Is it safe to take Tonadin supplements?

Yes, Tonadin is safe to take as a dietary supplement in the recommended dosages. However, it is important to speak to your doctor before taking any supplement or medication to ensure that the dosages are safe and appropriate.

Is Tonadin the same as Vitamin K2?

No, Tonadin (vitamin K1) is different from Vitamin K2 (menaquinone). Although they both serve similar functions, their sources and absorption methods are different. Vitamin K2 is found primarily in animal-based foods such as eggs, liver, and fermented dairy products, while Vitamin K1 is found primarily in dark green leafy vegetables.

Does Tonadin have any effect on the kidneys?

Research has not conclusively shown any direct effect of phylloquinone on the kidneys. However, it is important to consult with your doctor before taking any supplement to make sure that it does not interfere with any medications you may be taking.

Should I take Tonadin everyday?

It is important to speak to your doctor before taking any dietary supplement or medication. Depending on your doctor’s instructions, it may be advisable to take phylloquinone every day in order to meet the recommended daily intake.

Is Tonadin tied to any health risks?

High doses of Tonadin may cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Tonadin can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.

What is the difference between Tonadin and Vitamin K2?

Tonadin (vitamin K1) and Vitamin K2 (menaquinone) are both vitamers of Vitamin K, which serve similar functions in the body. Vitamin K1 is found primarily in dark green leafy vegetables, while Vitamin K2 is found primarily in animal-based foods such as eggs, liver, and fermented dairy products.

Does the body store Tonadin?

No, the body does not store Tonadin, so it is important to obtain it through dietary sources or supplements. Tonadin is found in dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens.

Does Tonadin have any effect on cholesterol levels?

Research has suggested that higher intakes of phylloquinone may be linked to lower levels of total cholesterol, as well as low-density lipoprotein (LDL), or “bad” cholesterol. However, more research is needed to confirm this potential link.

Can Tonadin be toxic if taken in large amounts?

Yes, phylloquinone can be toxic if taken in large amounts, and it is important to consult with your doctor before taking a supplement. High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising.

What happens if

https://www.medicinesfaq.com/brand/tonadin, http://classyfire.wishartlab.com/tax_nodes/C0000000, http://classyfire.wishartlab.com/tax_nodes/C0000012, http://classyfire.wishartlab.com/tax_nodes/C0000259, http://classyfire.wishartlab.com/tax_nodes/C0001534, http://classyfire.wishartlab.com/tax_nodes/C0001547, http://classyfire.wishartlab.com/tax_nodes/C0001551, http://classyfire.wishartlab.com/tax_nodes/C0000153, http://classyfire.wishartlab.com/tax_nodes/C0002495, http://classyfire.wishartlab.com/tax_nodes/C0003670, http://classyfire.wishartlab.com/tax_nodes/C0003940, http://classyfire.wishartlab.com/tax_nodes/C0004150, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18067, http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMPR02030028, http://www.hmdb.ca/metabolites/HMDB0015157, http://www.genome.jp/dbget-bin/www_bget?drug:D00148, http://www.genome.jp/dbget-bin/www_bget?cpd:C02059, https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284607, https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504528, https://www.chemspider.com/Chemical-Structure.4447652.html, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24782, https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8308, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=18067, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1550, https://zinc.docking.org/substances/ZINC000003831332, http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC001500, http://www.pharmgkb.org/drug/PA450961, https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/PQN, http://www.rxlist.com/cgi/generic3/phytonadione.htm, https://www.drugs.com/cdi/phytonadione.html, https://en.wikipedia.org/wiki/Phytomenadione,