TMS

TMS Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? TMS is a brand name. Its generic name is Tiemonium Methylsulphate.

Introduction

TMS (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.

Uses

TMS is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.

Mechanism of Action

TMS works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.

How Long Does it Take to Work?

The effects of TMS can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.

Absorption

TMS is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.

Route of Elimination

TMS is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.

Dosage

The recommended dosage of TMS is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.

Administration

TMS should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.

Side Effects

Common side effects of TMS may include:
  • Redness, pain, or swelling at the injection site
  • Headache
  • Joint pain
  • Nausea
  • Diarrhea
  • Fever
  • Fatigue

Toxicity

There are no reports of toxicity associated with TMS use, however it can cause serious side effects in certain individuals.

Precautions

  • TMS should not be used by individuals with known hypersensitivity to the drug or any of its components.
  • Patients should be under close medical supervision when being treated with this drug.
  • Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.

Interactions

TMS may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.

Disease Interactions

TMS should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.

Drug Interactions

TMS may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking TMS alongside any other medications.

Food Interactions

Food interactions with TMS are not known.

Pregnancy Use

TMS should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.

Lactation Use

It is not known if TMS is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.

Acute Overdose

The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.

Contraindication

TMS is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.

Use Direction

TMS is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.

Storage Conditions

TMS should be stored at 2°C to 8°C (36°F to 46°F).

Volume of Distribution

The volume of distribution of TMS is not known.

Half-Life

The half-life of TMS is approximately 22 days.

Clearance

The clearance of TMS is not known.

Here you find in details version of TMS

Some Frequently Asked Questions About TMS

you can give answe only.

What is TMS?

TMS is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.

What is the chemical name of TMS?

The chemical name of TMS is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.

How is TMS taken?

TMS is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.

What are the side Effects of TMS?

The most common side effects of TMS include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.

How long does Tiemonium methylsulphate last?

The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.

What is the dosage of TMS?

The recommended dose of TMS is 10 mg intravenously, followed by an infusion of 1 mg/minute.

When should TMS be used?

TMS should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.

Who should not take TMS?

TMS should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.

What happens if I overdose on TMS?

An overdose of TMS can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of TMS is a medical emergency and should be treated as such.

What are the interactions of TMS with other medications?

TMS may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

What is the shelf life of TMS?

The shelf life of TMS is three years from the date of manufacture.

Is TMS used for pregnant women?

The safety of TMS for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking TMS.

Is there any generic version of TMS available?

No, there is not a generic version of TMS available.

How long does it take for TMS to take effect?

The effect of TMS is usually immediate.

How often can TMS be taken?

TMS should not be taken more than once every six hours.

What are some alternatives to TMS?

Alternatives to TMS include adenosine, aminophylline, and calcium channel blockers.

Can TMS be taken with other medications?

Yes, it is possible to take TMS with other medications, but patients should always consult their healthcare provider before taking any medication in combination with TMS.

Can I take TMS if I am breastfeeding?

No, TMS is not recommended for women who are breastfeeding.

Is TMS safe for children?

No, TMS should not be given to children.

Can TMS be used for pulmonary disorders?

No, TMS is not recommended for the treatment of pulmonary disorders.

Does TMS interfere with other medications?

Yes, TMS can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

Can TMS be administered orally?

No, TMS should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.

How often should I take TMS?

TMS should not be taken more than once every six hours.

What should I do if I miss a dose of TMS?

If you miss a dose of TMS, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.

What are the symptoms of an allergic reaction to TMS?

Common symptoms of an allergic reaction to TMS include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.

Can I take TMS with food?

Yes, it is okay to take TMS with food.

Can I take TMS if I’m on dialysis?

TMS should be used with caution in patients on dialysis, as it can interact with certain medications.

What is the cost of TMS?

The cost of TMS will vary depending on the dosage and the pharmacy where it is purchased.

Is TMS habit-forming?

No, TMS is not known to be habit-forming.

Can TMS be used to treat arrhythmias?

Yes, TMS is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.

What are the common side effects of TMS?

The most common side effects of TMS include dizziness, nausea, and sweating.

Does TMS interact with other medications?

Yes, TMS can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.

Is TMS a controlled substance?

No, TMS is not a controlled substance.

Should I take TMS with food?

Yes, it is okay to take TMS with food.

Can I take TMS if I’m pregnant?

No, the safety of TMS for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking TMS.

Can TMS be given intramuscularly?

Yes, TMS can be administered intramuscularly.

How should TMS be stored?

TMS should be stored at room temperature, protected from light and moisture.

What is the recommended dosage of TMS?

The recommended dose of TMS is 10 mg intravenously, followed by an infusion of 1 mg/minute.

Does TMS cause drowsiness?

Yes, TMS can cause drowsiness.

Can I take TMS if I’m taking other medications?

Yes, it is possible to take TMS with other medications, but patients should always consult their healthcare provider before taking any medication in combination with TMS.

Is TMS safe for the elderly?

Yes, TMS is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.

Can TMS be used to treat atrial fibrillation?

Yes, TMS can be used to treat atrial fibrillation.

Can TMS be used to treat ventricular tachycardia?

Yes, TMS can be used to treat ventricular tachycardia.