Tium
Tium Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tium is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Tium (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Tium is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Tium works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Tium can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Tium is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Tium is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Tium is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Tium should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Tium may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Tium use, however it can cause serious side effects in certain individuals.Precautions
- Tium should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Tium may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Tium should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Tium may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Tium alongside any other medications.Food Interactions
Food interactions with Tium are not known.Pregnancy Use
Tium should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Tium is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Tium is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Tium is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Tium should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Tium is not known.Half-Life
The half-life of Tium is approximately 22 days.Clearance
The clearance of Tium is not known.Here you find in details version of Tium
Some Frequently Asked Questions About Tium
you can give answe only.What is Tium?
Tium is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Tium?
The chemical name of Tium is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Tium taken?
Tium is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Tium?
The most common side effects of Tium include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Tium?
The recommended dose of Tium is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Tium be used?
Tium should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Tium?
Tium should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Tium?
An overdose of Tium can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Tium is a medical emergency and should be treated as such.
What are the interactions of Tium with other medications?
Tium may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Tium?
The shelf life of Tium is three years from the date of manufacture.
Is Tium used for pregnant women?
The safety of Tium for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tium.
Is there any generic version of Tium available?
No, there is not a generic version of Tium available.
How long does it take for Tium to take effect?
The effect of Tium is usually immediate.
How often can Tium be taken?
Tium should not be taken more than once every six hours.
What are some alternatives to Tium?
Alternatives to Tium include adenosine, aminophylline, and calcium channel blockers.
Can Tium be taken with other medications?
Yes, it is possible to take Tium with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tium.
Can I take Tium if I am breastfeeding?
No, Tium is not recommended for women who are breastfeeding.
Is Tium safe for children?
No, Tium should not be given to children.
Can Tium be used for pulmonary disorders?
No, Tium is not recommended for the treatment of pulmonary disorders.
Does Tium interfere with other medications?
Yes, Tium can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Tium be administered orally?
No, Tium should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Tium?
Tium should not be taken more than once every six hours.
What should I do if I miss a dose of Tium?
If you miss a dose of Tium, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Tium?
Common symptoms of an allergic reaction to Tium include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Tium with food?
Yes, it is okay to take Tium with food.
Can I take Tium if I’m on dialysis?
Tium should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Tium?
The cost of Tium will vary depending on the dosage and the pharmacy where it is purchased.
Is Tium habit-forming?
No, Tium is not known to be habit-forming.
Can Tium be used to treat arrhythmias?
Yes, Tium is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Tium?
The most common side effects of Tium include dizziness, nausea, and sweating.
Does Tium interact with other medications?
Yes, Tium can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Tium a controlled substance?
No, Tium is not a controlled substance.
Should I take Tium with food?
Yes, it is okay to take Tium with food.
Can I take Tium if I’m pregnant?
No, the safety of Tium for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tium.
Can Tium be given intramuscularly?
Yes, Tium can be administered intramuscularly.
How should Tium be stored?
Tium should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Tium?
The recommended dose of Tium is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Tium cause drowsiness?
Yes, Tium can cause drowsiness.
Can I take Tium if I’m taking other medications?
Yes, it is possible to take Tium with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tium.
Is Tium safe for the elderly?
Yes, Tium is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Tium be used to treat atrial fibrillation?
Yes, Tium can be used to treat atrial fibrillation.
Can Tium be used to treat ventricular tachycardia?
Yes, Tium can be used to treat ventricular tachycardia.