Tienum
Tienum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tienum is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Tienum (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Tienum is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Tienum works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Tienum can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Tienum is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Tienum is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Tienum is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Tienum should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Tienum may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Tienum use, however it can cause serious side effects in certain individuals.Precautions
- Tienum should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Tienum may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Tienum should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Tienum may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Tienum alongside any other medications.Food Interactions
Food interactions with Tienum are not known.Pregnancy Use
Tienum should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Tienum is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Tienum is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Tienum is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Tienum should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Tienum is not known.Half-Life
The half-life of Tienum is approximately 22 days.Clearance
The clearance of Tienum is not known.Here you find in details version of Tienum
Some Frequently Asked Questions About Tienum
you can give answe only.What is Tienum?
Tienum is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Tienum?
The chemical name of Tienum is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Tienum taken?
Tienum is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Tienum?
The most common side effects of Tienum include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Tienum?
The recommended dose of Tienum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Tienum be used?
Tienum should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Tienum?
Tienum should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Tienum?
An overdose of Tienum can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Tienum is a medical emergency and should be treated as such.
What are the interactions of Tienum with other medications?
Tienum may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Tienum?
The shelf life of Tienum is three years from the date of manufacture.
Is Tienum used for pregnant women?
The safety of Tienum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tienum.
Is there any generic version of Tienum available?
No, there is not a generic version of Tienum available.
How long does it take for Tienum to take effect?
The effect of Tienum is usually immediate.
How often can Tienum be taken?
Tienum should not be taken more than once every six hours.
What are some alternatives to Tienum?
Alternatives to Tienum include adenosine, aminophylline, and calcium channel blockers.
Can Tienum be taken with other medications?
Yes, it is possible to take Tienum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tienum.
Can I take Tienum if I am breastfeeding?
No, Tienum is not recommended for women who are breastfeeding.
Is Tienum safe for children?
No, Tienum should not be given to children.
Can Tienum be used for pulmonary disorders?
No, Tienum is not recommended for the treatment of pulmonary disorders.
Does Tienum interfere with other medications?
Yes, Tienum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Tienum be administered orally?
No, Tienum should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Tienum?
Tienum should not be taken more than once every six hours.
What should I do if I miss a dose of Tienum?
If you miss a dose of Tienum, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Tienum?
Common symptoms of an allergic reaction to Tienum include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Tienum with food?
Yes, it is okay to take Tienum with food.
Can I take Tienum if I’m on dialysis?
Tienum should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Tienum?
The cost of Tienum will vary depending on the dosage and the pharmacy where it is purchased.
Is Tienum habit-forming?
No, Tienum is not known to be habit-forming.
Can Tienum be used to treat arrhythmias?
Yes, Tienum is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Tienum?
The most common side effects of Tienum include dizziness, nausea, and sweating.
Does Tienum interact with other medications?
Yes, Tienum can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Tienum a controlled substance?
No, Tienum is not a controlled substance.
Should I take Tienum with food?
Yes, it is okay to take Tienum with food.
Can I take Tienum if I’m pregnant?
No, the safety of Tienum for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tienum.
Can Tienum be given intramuscularly?
Yes, Tienum can be administered intramuscularly.
How should Tienum be stored?
Tienum should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Tienum?
The recommended dose of Tienum is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Tienum cause drowsiness?
Yes, Tienum can cause drowsiness.
Can I take Tienum if I’m taking other medications?
Yes, it is possible to take Tienum with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tienum.
Is Tienum safe for the elderly?
Yes, Tienum is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Tienum be used to treat atrial fibrillation?
Yes, Tienum can be used to treat atrial fibrillation.
Can Tienum be used to treat ventricular tachycardia?
Yes, Tienum can be used to treat ventricular tachycardia.