Tiemo
Tiemo Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tiemo is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Tiemo (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Tiemo is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Tiemo works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Tiemo can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Tiemo is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Tiemo is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Tiemo is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Tiemo should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Tiemo may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Tiemo use, however it can cause serious side effects in certain individuals.Precautions
- Tiemo should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Tiemo may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Tiemo should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Tiemo may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Tiemo alongside any other medications.Food Interactions
Food interactions with Tiemo are not known.Pregnancy Use
Tiemo should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Tiemo is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Tiemo is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Tiemo is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Tiemo should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Tiemo is not known.Half-Life
The half-life of Tiemo is approximately 22 days.Clearance
The clearance of Tiemo is not known.Here you find in details version of Tiemo
Some Frequently Asked Questions About Tiemo
you can give answe only.What is Tiemo?
Tiemo is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Tiemo?
The chemical name of Tiemo is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Tiemo taken?
Tiemo is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Tiemo?
The most common side effects of Tiemo include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Tiemo?
The recommended dose of Tiemo is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Tiemo be used?
Tiemo should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Tiemo?
Tiemo should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Tiemo?
An overdose of Tiemo can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Tiemo is a medical emergency and should be treated as such.
What are the interactions of Tiemo with other medications?
Tiemo may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Tiemo?
The shelf life of Tiemo is three years from the date of manufacture.
Is Tiemo used for pregnant women?
The safety of Tiemo for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tiemo.
Is there any generic version of Tiemo available?
No, there is not a generic version of Tiemo available.
How long does it take for Tiemo to take effect?
The effect of Tiemo is usually immediate.
How often can Tiemo be taken?
Tiemo should not be taken more than once every six hours.
What are some alternatives to Tiemo?
Alternatives to Tiemo include adenosine, aminophylline, and calcium channel blockers.
Can Tiemo be taken with other medications?
Yes, it is possible to take Tiemo with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tiemo.
Can I take Tiemo if I am breastfeeding?
No, Tiemo is not recommended for women who are breastfeeding.
Is Tiemo safe for children?
No, Tiemo should not be given to children.
Can Tiemo be used for pulmonary disorders?
No, Tiemo is not recommended for the treatment of pulmonary disorders.
Does Tiemo interfere with other medications?
Yes, Tiemo can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Tiemo be administered orally?
No, Tiemo should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Tiemo?
Tiemo should not be taken more than once every six hours.
What should I do if I miss a dose of Tiemo?
If you miss a dose of Tiemo, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Tiemo?
Common symptoms of an allergic reaction to Tiemo include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Tiemo with food?
Yes, it is okay to take Tiemo with food.
Can I take Tiemo if I’m on dialysis?
Tiemo should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Tiemo?
The cost of Tiemo will vary depending on the dosage and the pharmacy where it is purchased.
Is Tiemo habit-forming?
No, Tiemo is not known to be habit-forming.
Can Tiemo be used to treat arrhythmias?
Yes, Tiemo is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Tiemo?
The most common side effects of Tiemo include dizziness, nausea, and sweating.
Does Tiemo interact with other medications?
Yes, Tiemo can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Tiemo a controlled substance?
No, Tiemo is not a controlled substance.
Should I take Tiemo with food?
Yes, it is okay to take Tiemo with food.
Can I take Tiemo if I’m pregnant?
No, the safety of Tiemo for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Tiemo.
Can Tiemo be given intramuscularly?
Yes, Tiemo can be administered intramuscularly.
How should Tiemo be stored?
Tiemo should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Tiemo?
The recommended dose of Tiemo is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Tiemo cause drowsiness?
Yes, Tiemo can cause drowsiness.
Can I take Tiemo if I’m taking other medications?
Yes, it is possible to take Tiemo with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Tiemo.
Is Tiemo safe for the elderly?
Yes, Tiemo is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Tiemo be used to treat atrial fibrillation?
Yes, Tiemo can be used to treat atrial fibrillation.
Can Tiemo be used to treat ventricular tachycardia?
Yes, Tiemo can be used to treat ventricular tachycardia.