Ticagen

Ticagen Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ticagen is a brand name. Its generic name is Ticagrelor.

Ticagen Introduction

Ticagen is an antiplatelet medication that is used to reduce the rate of cardiovascular events, including death. It belongs to a class of drugs called cyclooxygenase (COX)-2 inhibitors. It works by reducing the production of thromboxane A2 (TXA2), a platelet-activating molecule that can lead to clot formation. Ticagen is used in most countries to reduce the risk of stroke and heart attack in people with established or at high risk of cardiovascular disease.

Uses for Ticagen

Ticagen is used to reduce the risk of death or stroke in patients with acute coronary syndrome (ACS). It is also recommended for those with acute ischemic stroke in some countries, and for reducing the risk of peripheral arterial disease in patients with coronary artery disease. It is also sometimes used to reduce angina in some patients.

Mechanism of Action

Ticagen works by blocking the action of the enzyme cyclooxygenase-2 (COX-2), which is responsible for the production of thromboxane A2 (TXA2), a platelet-activating molecule. By blocking TXA2, ticagrelor reduces the chances of clot formation. It also helps to keep platelets from sticking to each other, which prevents them from clumping together and creating clots. This helps to reduce the risk of stroke and heart attack.

How Long Does it Take to Work?

Ticagen generally takes effect within 10 minutes after it is taken. The effects lasts for about a day, until the body has processed and eliminated the medication.

Absorption

Ticagen is rapidly and almost completely absorbed after oral administration. The maximum concentration is usually reached within 1–2 hours.

Route of Elimination

Ticagen is mainly eliminated through the kidneys. It is excreted in the urine as unchanged drug and metabolites.

Dosage

The recommended adult dosage for ticagrelor is 60 mg twice daily. It should be taken with food to reduce the risk of stomach and intestine irritation. It is not recommended for patients with severe renal impairment.

Administration

Ticagen is usually taken by mouth, as a tablet or an oral suspension. It is recommended to be taken with food. It should be taken exactly as prescribed by the doctor.

Side Effects

Common side effects of ticagrelor include headache, indigestion, nausea, vomiting, diarrhea, dizziness, fatigue, and rash. Rare side effects can include bleeding complications, hypotension, and liver problems.

Toxicity

Ticagen is safe when used as recommended. The most serious effect of overdose is bleeding. Seek medical attention immediately if you suspect an overdose.

Precaution

Ticagen should be used with caution in patients with a history of bleeding disorders or who take other medications that increase the risk of bleeding. It is also not recommended for pregnant women and those who are breastfeeding.

Interaction

Ticagen may interact with certain drugs, including anticoagulants, antiplatelet drugs, and nonsteroidal anti-inflammatory drugs (NSAIDs). It is important to tell your doctor about all medications and supplements, including vitamins and herbal products, you are taking before taking ticagrelor.

Disease Interaction

Ticagen may interact with diseases such as liver disease, kidney disease, and bleeding disorders. Tell your doctor about any medical conditions you may have before taking ticagrelor.

Drug Interaction

Ticagen may interact with other medications, including anticoagulants, antiplatelet drugs, and nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your doctor about all medications and supplements, including vitamins and herbal products, you are taking before taking ticagrelor.

Food Interaction

Food does not significantly affect the absorption of ticagrelor, but it is recommended to take the medication with food to reduce the risk of stomach and intestine irritation.

Pregnancy Use

Ticagen is not recommended for use during pregnancy. It has the potential to cause serious harm to a developing fetus.

Lactation Use

Ticagen is excreted in breast milk and is not recommended for use while breastfeeding. It may cause serious harm to a nursing baby.

Acute Overdose

If an overdose is suspected, seek medical attention immediately. The most serious effect of overdose is bleeding.

Contraindication

Ticagen is contraindicated in patients with a history of severe renal impairment, a history of bleeding disorders, during pregnancy and breastfeeding, and in patients taking other medications that increase the risk of bleeding.

Use Direction

Ticagen should be taken exactly as prescribed by the doctor. It is usually taken orally, as a tablet or an oral suspension with food. It is not recommended for use in patients with severe renal impairment.

Storage Condition

Ticagen should be stored at room temperature away from direct sunlight and heat. Keep it in a dry place and out of reach of children.

Volume of Distribution

The volume of distribution of ticagrelor in humans is approximately 176 L, indicating widespread distribution of the drug throughout the body.

Half Life

The half-life of ticagrelor is approximately 8 hours. After 24 hours, the drug has been largely eliminated from the body.

Clearance

The clearance of ticagrelor is approximately 21 L/h, indicating that it is quickly cleared from the body. It is mainly eliminated through the kidneys as unchanged drug and metabolites.

Here you find in details version of Ticagen

Some Frequently Asked Questions About Ticagen

What is Ticagen?

Ticagen is an antiplatelet medicine that reduces the risk of having a stroke or heart attack. It works by lowering the amount of clots in the blood, preventing blood vessel blockages.

Who should take Ticagen?

Ticagen is typically prescribed for people who have already had a heart attack or stroke, along with those at risk for having one. Your health care provider can help you determine if Ticagen is right for you.

How is Ticagen taken?

Ticagen comes in tablet form and is usually taken once or twice a day. It should be taken with food to help prevent stomach upset. It is important to take Ticagen as directed by your health care provider.

What are the side effects of Ticagen?

The most common side effects of Ticagen include headache, nausea, heartburn, indigestion, and diarrhea. Other side effects may include dizziness, rash, and low blood counts. Talk to your health care provider if you are concerned about side effects.

What is the recommended dose of Ticagen?

The usual recommended dose of Ticagen is 60 or 90 mg twice daily. The exact dose will depend on various factors, such as your body weight and other medications you are taking. Your health care provider will determine the best dose for you.

Is there an upper limit for the dose of Ticagen?

No, there is no upper limit for the dose of Ticagen; however, the higher the dose, the greater the risk of side effects. Your health care provider will recommend a dose of Ticagen that is most appropriate for you.

Does Ticagen interact with other medications?

Yes, Ticagen can interact with certain other medications, including warfarin, aspirin, and ibuprofen. Always tell your health care provider about any other medications you are taking so they can evaluate how Ticagen will interact with them.

What should I do if I miss a dose of Ticagen?

If you miss a dose of Ticagen, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose of Ticagen.

How long does it take for Ticagen to work?

It usually takes about two hours for Ticagen to start reducing the risk of blood clots. However, its full effect may take up to two days after starting treatment.

Is Ticagen safe for pregnant women?

Ticagen is not recommended for pregnant women as there is not enough data available to evaluate the drug's safety. If you are pregnant or plan to become pregnant, talk to your health care provider about the risks and benefits of taking Ticagen.

Does Ticagen cause stomach ulcers?

Ticagen may cause stomach ulcers since it is an antiplatelet medicine that prevents the formation of clots. Taking the drug with food can help reduce the risk of stomach ulcers. If you experience any stomach pain, contact your health care provider.

What should I tell my health care provider before taking Ticagen?

Before starting treatment with Ticagen, you should let your health care provider know about any other medications you are taking, as well as any allergies or medical conditions you have. You should also tell your provider if you drink alcohol regularly or if you are pregnant or breastfeeding.

Can Ticagen be used to treat high blood pressure?

No, Ticagen is used to reduce the risk of stroke or heart attack, not to treat high blood pressure.

How should I store Ticagen?

Ticagen should be stored at room temperature away from moisture and heat. Keep the medicine in its original container, and do not keep it in the refrigerator or freezer.

Can I drink alcohol while taking Ticagen?

It is not recommended to drink alcohol while taking Ticagen since alcohol can increase the risk of bleeding. Talk to your health care provider before drinking while taking Ticagen.

What if I experience severe bleeding while taking Ticagen?

If you experience signs of severe bleeding, such as heavy menstrual bleeding or vomiting blood, contact your health care provider right away.

Can Ticagen be taken with other blood thinners?

Ticagen can be taken with other blood thinners such as warfarin. However, it is important to let your doctor know if you are taking any other medications. Your doctor can help you determine which medications are appropriate for you.

Can I take Ticagen if I have kidney disease?

Yes, Ticagen can be taken if you have kidney disease. Your health care provider will determine the best dose for you based on the severity of your condition.

Can I take Ticagen if I am allergic to aspirin?

Yes, you can take Ticagen if you are allergic to aspirin. However, it is important to let your health care provider know before starting treatment.

What should I avoid while taking Ticagen?

You should avoid activities that have a high risk of causing bleeding, such as contact sports. In addition, you should avoid taking any other medications without speaking to your health care provider.

What are the symptoms of an allergic reaction to Ticagen?

Symptoms of an allergic reaction to Ticagen may include hives, rash, itching, facial swelling, fainting, and difficulty breathing. If you experience any of these symptoms, contact your health care provider right away.

Can Ticagen be used in combination with other medications?

Yes, Ticagen can be taken in combination with other medications. However, it is important to let your health care provider know about any other medications you are taking before starting Ticagen treatment.

What should I do if I experience chest pain while taking Ticagen?

If you experience chest pain while taking Ticagen, contact your health care provider right away. Chest pain may be a sign of a serious medical condition and should be evaluated by a doctor.

Can I take Ticagen if I have liver disease?

Yes, Ticagen can be taken if you have liver disease. Your health care provider will adjust your dose as needed based on the severity of your condition.

Are there any foods or drinks I should avoid while taking Ticagen?

You should avoid eating grapefruit or drinking grapefruit juice while taking Ticagen as it can increase the risk of side effects. You should also avoid drinking alcohol while taking Ticagen, as it can increase the risk of bleeding.

Will Ticagen lower my blood pressure?

Ticagen is not designed to lower your blood pressure but it can help reduce the risk of stroke and heart attack. If you are concerned about your blood pressure, talk to your health care provider.

Can I take Ticagen if I have a history of bleeding?

Ticagen may not be the best treatment option for someone with a history of bleeding. Your health care provider can evaluate your condition and determine the best treatment for you.

Can Ticagen be taken with anti-inflammatory medications?

Yes, Ticagen can be taken with anti-inflammatory medications such as ibuprofen. However, it is important to let your health care provider know before starting Ticagen treatment.

What is the most common side effect of Ticagen?

The most common side effect of Ticagen is headache. Other side effects may include nausea, heartburn, indigestion, and diarrhea. Talk to your health care provider if you are concerned about side effects.

Can I take Ticagen if I have diabetes?

Yes, Ticagen can be taken if you have diabetes. Your health care provider will determine the best dose for you based on your condition.

Can Ticagen be taken with antacids?

Yes, Ticagen can be taken with antacids. However, it is important to take the antacids at least two hours before or after taking Ticagen to reduce the risk of side effects.

What happens if I take an overdose of Ticagen?

If you take an overdose of Ticagen, contact your health care provider or local poison control center right away. Signs of an overdose may include severe stomach pain, bleeding, or difficulty breathing.

Is Ticagen safe for children?

Ticagen is not recommended for children under 18 years of age. If your child needs an antiplatelet medicine, your health care provider can recommend an appropriate treatment.

Can Ticagen cause hair loss?

No, Ticagen typically does not cause hair loss. If you are experiencing hair loss, contact your health care provider to discuss other potential causes.

What should I do if I forget to take a dose of Ticagen?

If you forget to take a dose of Ticagen, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose of Ticagen.

Can I take Ticagen if I am older than 65?

Yes, Ticagen can be taken if you are older than 65. However, your health care provider may adjust the dose of Ticagen based on your age and other medical conditions.

Can Ticagen cause fatigue?

Yes, Ticagen can cause fatigue. If you experience severe or prolonged fatigue, contact your health care provider to discuss other potential causes.

Can Ticagen cause weight gain?

No, Ticagen does not typically cause weight gain. If you are experiencing weight gain, contact your health care provider to discuss other potential causes.

Can Ticagen be used to treat clogged arteries?

No, Ticagen is not used to treat clogged arteries. If you have clogged arteries, your health care provider can evaluate your condition and recommend an appropriate treatment.

What should I do if my symptoms worsen while taking Ticagen?

If your symptoms worsen while taking Ticagen, contact your health care provider. Your doctor can adjust your dose or switch you to a different medication to reduce the risk of complications.