Tenoren Plus

Tenoren Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tenoren Plus is a brand name. Its generic name is Atenolol + Chlorthalidone.

Atenolol and Chlorthalidone Introduction

Atenolol and Chlorthalidone (also known as Tenoretic) is a combination of two drug substances, Atenolol and Chlorthalidone, used in the treatment of hypertension (high blood pressure) to reduce cardiovascular risk in individuals who have been diagnosed with hypertension. It is a beta-blocker and diuretic combination reach which makes it a more powerful alternative to the individual components.

Uses for Atenolol and Chlorthalidone

Atenolol and Chlorthalidone are used to treat hypertension (high blood pressure) in adults and children 6 years of age and older. It may be used alone or in combination with other antihypertensive medications. This medication is also used to treat and prevent chest pain (angina) and reduce the risk of heart attack and stroke.

Mechanism of Action

The combination of Atenolol and Chlorthalidone works by targeting two separate mechanisms that can result in hypertension. Atenolol is a beta-blocker that works by blocking certain receptors in the heart and blood vessels, resulting in a decrease in the heart rate and blood pressure. Chlorthalidone is a diuretic, which increases the water and salt excretion from the body, resulting in less fluid in the blood vessels and leading to lower blood pressure.

How Long Does it Take to Work?

The full effects of Atenolol and Chlorthalidone on blood pressure control can take 1 to 2 weeks to appear. However, some individuals may experience a decrease in blood pressure within a few days or weeks of starting treatment.

Absorption

Atenolol is approximately 30% to 50% absorbed orally, with peak plasma concentrations occurring within 2 to 4 hours after administration. Chlorthalidone is rapidly absorbed and reaches peak plasma concentrations 1 to 4 hours after administration.

Route of Elimination

Atenolol is eliminated predominantly via the kidneys, and Chlorthalidone is eliminated in the kidneys and in the feces.

Dosage

Atenolol and Chlorthalidone are available in a fixed-dose combination tablet containing 25mg of atenolol and 50mg of chlorthalidone. The usual starting dosage is one tablet taken once daily. The dose may be increased to one tablet taken twice a day, if needed.

Administration

Atenolol and Chlorthalidone tablets should be taken orally with or without food and at the same time(s) each day to maintain an even level of medication in the body.

Side Effects

The most common side effects of Atenolol and Chlorthalidone include dizziness, lightheadedness, dry mouth, fatigue, insomnia, constipation, diarrhea, nausea, vomiting, skin rash, and muscle pain.

Toxicity

Atenolol and Chlorthalidone have a low potential for toxicity. However, overdose of Atenolol can cause severe symptoms such as a slow heart rate, fainting, difficulty breathing, and coma. Overdose of Chlorthalidone can lead to muscle weakness, confusion, and severe dehydration.

Precautions

Atenolol and Chlorthalidone should not be used during pregnancy or while breastfeeding. Additionally, caution must be taken when administering Atenolol and Chlorthalidone to patients with kidney, liver, or heart disease, as they may be more sensitive to the effects.

Interactions

Atenolol and Chlorthalidone may interact with other medications, including antidiabetic drugs, anticoagulants, and nonsteroidal anti-inflammatory drugs, so it is important to inform your doctor or pharmacist of any medications you are taking before starting treatment.

Disease Interactions

Patients with diabetes, heart failure, glaucoma, respiratory disorders, or thyroid disorders may experience increased risk for adverse effects when taking Atenolol and Chlorthalidone.

Drug Interactions

Atenolol and Chlorthalidone may interact with other medications, including antidiabetic drugs, anticoagulants, and nonsteroidal anti-inflammatory drugs, so it is important to inform your doctor or pharmacist of any medications you are taking before starting treatment.

Food Interactions

Atenolol and Chlorthalidone may interact with certain foods, such as high-fat dairy products, alcohol, and high-protein or high-calorie diets. It is important to check with your doctor or pharmacist before consuming any foods that may interact with the medication.

Pregnancy Use

Atenolol and Chlorthalidone is not recommended for use during pregnancy due to the risk for birth defects and serious side effects in the fetus.

Lactation Use

Atenolol and Chlorthalidone is not recommended for use while breastfeeding due to the risk for side effects in the infant.

Acute Overdose

Treatment of an acute overdose of Atenolol and Chlorthalidone may include supportive care, such as rest, blood pressure monitoring, and adjustment of medications.

Contraindications

Atenolol and Chlorthalidone should not be used if you are allergic to either ingredient. It should also not be used by patients with certain heart conditions or pregnant or breastfeeding women.

Use Directions

It is important to take Atenolol and Chlorthalidone as it has been prescribed by your doctor. This medication should be taken at the same time(s) each day to maintain an even level of medication in the body.

Storage Conditions

Atenolol and Chlorthalidone should be stored at room temperature away from light and moisture. It should also be kept away from children and pets.

Volume of Distribution

The volume of distribution of Atenolol and Chlorthalidone is estimated to be about 0.6L/kg.

Half-Life

The half-life of Atenolol is approximately 6-10 hours, and the half-life of Chlorthalidone is around 24 to 36 hours.

Clearance

The oral clearance of Atenolol is about 0.4-0.7 mL/min/kg, and the oral clearance of Chlorthalidone is about 0.2 mL/min/kg.

Here you find in details version of Tenoren Plus

Some Frequently Asked Questions About Tenoren Plus

What is Tenoren Plus?

Tenoren Plus is a combination medication that contains two active ingredients: atenolol and chlorthalidone. Atenolol is a beta-blocker that works by slowing down the heart rate and preventing it from becoming too fast. Chlorthalidone is a diuretic or “water pill” that helps the body get rid of unneeded fluids. This medication is used to treat high blood pressure.

What is the most important information I should know about Tenoren Plus?

Tenoren Plus may cause dizziness, lightheadedness, or fainting. This is more likely when you start the medication. These effects can also increase when your dose is increased. You should sit or lie down when you take your dose and stay in that position for several minutes. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather.

How long should I take Tenoren Plus?

It is important to take Tenoren Plus exactly as your doctor prescribes, and for as long as they prescribe. Even if you feel like your blood pressure is under control, do not stop your medication without talking to your doctor. Stopping this medication can cause an increase in your blood pressure.

How do I take Tenoren Plus?

It is important to take Tenoren Plus exactly as prescribed by your doctor. Take each dose with a full glass of water. Do not crush or chew the tablets. Take the medication at the same time each day.

What should I avoid while taking Tenoren Plus?

Avoid activities that require alertness or physical coordination until you know how Tenoren Plus affects you. Avoid becoming overheated or dehydrated during exercise and hot weather. Avoid drinking alcohol as it can further lower your blood pressure and increase dizziness.

What are the possible side effects of Tenoren Plus?

Common side effects of Tenoren Plus include dizziness, lightheadedness, tiredness, and minor swelling in the hands and feet. Rare side effects include skin rash, depression, and difficulty sleeping. Tell your doctor if you experience any side effect that is severe or does not go away.

What should I do if I miss a dose of Tenoren Plus?

If you miss a dose of Tenoren Plus, take it as soon as you remember. If it is close to your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed dose.

Is Tenoren Plus safe to take during pregnancy?

Tenoren Plus is classified by the U.S. Food and Drug Administration (FDA) as pregnancy category C. This means it is not known whether Tenoren Plus will harm an unborn baby. Talk to your doctor about the risks and benefit of taking the medication while pregnant.

Should I avoid certain foods while taking Tenoren Plus?

Yes. Certain foods can interact with Tenoren Plus and cause a potentially dangerous increase in your blood pressure. This includes foods high in potassium such as bananas, tomatoes, and oranges. Ask your doctor for a full list of foods to avoid.

Does Tenoren Plus cause weight gain?

Weight gain is not a common side effect of Tenoren Plus. However, if you do experience weight gain while taking Tenoren Plus, talk to your doctor about ways to control your weight.

Can I take other medications while taking Tenoren Plus?

Talk to your doctor before taking any other medications while taking Tenoren Plus. Certain medications can interact and cause dangerous side effects. Make sure your doctor is aware of all other medications, supplements, and vitamins you are taking.

Can I drink alcohol while taking Tenoren Plus?

No. It is not recommended to drink alcohol while taking Tenoren Plus. Alcohol can interact with the medication and cause a dangerous decrease in your blood pressure. We recommend avoiding alcohol while taking Tenoren Plus.

What should I do if I experience dizziness or lightheadedness while taking Tenoren Plus?

If you experience dizziness or lightheadedness while taking Tenoren Plus, sit or lie down right away. Remain in a sitting or lying position until you feel better. Do not stand up too quickly or you may become dizzy again. If the dizziness persists, contact your doctor.

Can I take Tenoren Plus if I have a heart condition?

Yes. Tenoren Plus can be used to treat high blood pressure in people with heart conditions. However, it is important to discuss any heart condition you have with your doctor before starting Tenoren Plus. Your doctor may need to adjust your dose to avoid any possible interactions or adverse reactions.

Does Tenoren Plus raise blood sugar levels?

Tenoren Plus can cause a slight increase in blood sugar levels. If you have diabetes, monitor your blood sugar levels more regularly when taking Tenoren Plus. Talk to your doctor if your blood sugar levels are consistently high while taking this medication.

Does Tenoren Plus interact with other medications?

Yes. Tenoren Plus can interact with certain medications and cause dangerous side effects. Make sure your doctor is aware of all other medications, supplements, and vitamins you are taking. Do not start or stop any medications without consulting your doctor.

Is Tenoren Plus available in generic form?

Yes. Tenoren Plus is available in generic form. Generic forms of medication work just as well as their brand-name counterparts but tend to be much less expensive.

Can I take over-the-counter medications while taking Tenoren Plus?

Yes, but it is important to check with your doctor before taking any over-the-counter medications. Certain over-the-counter medications can interact with Tenoren Plus and cause dangerous side effects.

Is there an alternative to Tenoren Plus?

Yes. Other medications such as beta-blockers, diuretics, ACE inhibitors, and calcium channel blockers can be used to treat high blood pressure. Talk to your doctor about the best treatment option for you.

Can Tenoren Plus cause hair loss?

Hair loss is a rare side effect of Tenoren Plus. If you experience hair loss while taking this medication, talk to your doctor as soon as possible.

What should I do if I experience an allergic reaction to Tenoren Plus?

If you experience an allergic reaction to Tenoren Plus, such as hives, rash, itching, difficulty breathing, or swelling of the face, lips, or tongue, seek medical attention immediately. Discontinue the use of the medication and contact your doctor.

Can I take herbal supplements while taking Tenoren Plus?

It is not recommended to take herbal supplements while taking Tenoren Plus as they can interact with the medication and cause dangerous side effects. Talk to your doctor before taking any supplements while taking this medication.

What happens if I overdose on Tenoren Plus?

If you overdose on Tenoren Plus, seek medical attention immediately. Symptoms of an overdose can include dizziness, confusion, slow heartbeat, and difficulty breathing.

Does Tenoren Plus have any long-term effects?

Tenoren Plus has not been associated with any long-term side effects when taken as prescribed. It is important to take the medication as prescribed and talk to your doctor if you experience any side effects.

Can children take Tenoren Plus?

No. Tenoren Plus is not recommended for use in children. Talk to your doctor about other treatment options for children.

Should I take Tenoren Plus with food?

No. It is important to take Tenoren Plus on an empty stomach to ensure the full absorption of the medication. Do not eat for at least one hour before or two hours after taking the medication.

Can I take Tenoren Plus if I have asthma?

Yes. Tenoren Plus can be used to treat high blood pressure in people with asthma. However, it is important to discuss your asthma with your doctor before starting Tenoren Plus. Your doctor may need to adjust your dose to avoid any possible interactions.

Does Tenoren Plus affect the liver?

No. Tenoren Plus is not known to affect the liver. However, it is important to talk to your doctor if you have liver disease before starting this medication as the dose may need to be adjusted.

Can Tenoren Plus cause constipation?

Yes. Constipation is a possible side effect of Tenoren Plus. If you experience constipation while taking this medication, talk to your doctor about ways to relieve the symptoms.

Does Tenoren Plus increase urination?

Yes. Tenoren Plus is a diuretic or “water pill” that helps the body rid itself of unneeded fluids. This can lead to an increased urge to urinate during the day and night.

Does Tenoren Plus lower cholesterol levels?

No, Tenoren Plus is not known to lower cholesterol levels. However, it may be prescribed in some cases if your doctor feels it necessary. Your doctor may recommend other medications to lower cholesterol levels.

Does Tenoren Plus interact with other vitamins or minerals?

Yes, Tenoren Plus can interact with certain vitamins and minerals. It is important to discuss all vitamins and minerals you are taking with your doctor before taking Tenoren Plus. Some vitamins and minerals to be aware of include potassium, calcium, and magnesium.

Can I exercise while taking Tenoren Plus?

Yes. Exercise is important to stay healthy. Talk to your doctor before you start any new physical activity while taking Tenoren Plus, as the medication can cause dizziness and lightheadedness.

Can I breastfeed or get pregnant while taking Tenoren Plus?

It is not recommended to breastfeed while taking Tenoren Plus. If you are pregnant or planning a pregnancy, talk to your doctor before taking the medication. Tenoren Plus is classified by the U.S. Food and Drug Administration